2-GUANIDINOETHYLMERCAPTOSUCCINIC ACID

Product Name: 2-GUANIDINOETHYLMERCAPTOSUCCINIC ACID
CAS No.: 77482-44-1
Chemical Name: 2-GUANIDINOETHYLMERCAPTOSUCCINIC ACID
Synonyms: GEMSA;2-Guanidinoethylthiosuccinic acid;GUANIDINOETHYLMERCAPTO-SUCCINIC ACID;2-GUANIDINOETHYLMERCAPTOSUCCINIC ACID;2-(2-Guanidinoethylthio)succinic acid;2-[(2-Guanidinoethyl)thio]succinic acid;(2-Guanidinoethylthio)succinic acid, GEMSA;(2-GUANIDINOETHYLMERCAPTO)SUCCINIC ACID 99+%;2-Guanidinoethylmercaptosuccinic acid (GEMSA);2-[(2-carbaMiMidaMidoethyl)sulfanyl]succinicacid
CBNumber: CB3257755
Molecular Formula: C7H13N3O4S
Formula Weight: 235.26
MOL File: 77482-44-1.mol

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2-GUANIDINOETHYLMERCAPTOSUCCINIC ACID Property

Melting point:: ~180 °C (dec.)
storage temp.: 2-8°C
solubility: Soluble in DMSO
form: White solid

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Safety

Safety Statements: 22-24/25

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 369334
Product name: 2-Guanidinoethylmercaptosuccinic Acid
Packaging: 5mg
Price: $245
Updated: 2024/03/01

Cayman Chemical

Product number: 19354
Product name: 2-Guanidinoethylmercaptosuccinic Acid
Purity: ≥98%
Packaging: 5mg
Price: $183
Updated: 2024/03/01

ApexBio Technology

Product number: C3265
Product name: 2-Guanidinoethylmercaptosuccinic Acid
Packaging: 5mg
Price: $201
Updated: 2021/12/16

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2-GUANIDINOETHYLMERCAPTOSUCCINIC ACID Chemical Properties,Usage,Production

Biological Activity

ki: 8.8 nm2-guanidinoethylmercaptosuccinic acid is a carboxypeptidase e inhibitor.carboxypeptidase e, also known as enkephalin convertase, can remove c-terminal residues during the processing of propeptides, such as enkephalin and proinsulin.

in vitro

2-guanidinoethylmercaptosuccinic acid was identified as a biproduct analogs of lysine and arginine that showed potent inhibitory effect on enkephalin convertase with the ki value of 8.8 nm. in addition, 2-guanidinoethylmercaptosuccinic acid was found to be several hundred fold more potent towards enkephalin convertase than towards carboxypeptidase b or n and the kinetic analyses indicated the pure competitive nature of the inhibition [1].

in vivo

previous study found that following the intrathecal administration of 2-guanidinoethylmercaptosuccinic acid at 12.5, 25 and 50 micrograms, an increase in the tail-flick latency was seen. in addition, 2-guanidinoethylmercaptosuccinic acid could potentiate the analgesic effects of the intrathecally applied met5-enkephalin-arg6-phe7 and met5-enkephalin-arg6-gly7-leu8. all these effects of 2-guanidinoethylmercaptosuccinic acid were significantly attenuated by the treatment of naloxone. moreover, the rats subjected to chronic pain showed a weaker analgesic response to the treatment of 2-guanidinoethylmercaptosuccinic acid. furthermore, 2-guanidinoethylmercaptosuccinic acid bound to enkephalin convertase in the spinal cord of these rats produced only a slight increase in kd [2].

References

1. fricker ld, plummer th jr, snyder sh. enkephalin convertase: potent, selective, and irreversible inhibitors. biochem biophys res commun. 1983 mar 29;111(3):994-1000.2. m. bommer, k. nikolarakis, e. p. noble, et al. in vivo modulation of rat hypothalamic opioid peptide content by intracerebroventricular injection of guanidinoethylmercaptosuccinic acid (gemsa): possible physiological role of enkephalin convertase. brain research 492(1-2), 305-313 (1989).

2-GUANIDINOETHYLMERCAPTOSUCCINIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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2-GUANIDINOETHYLMERCAPTOSUCCINIC ACID Suppliers

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77482-44-1, 2-GUANIDINOETHYLMERCAPTOSUCCINIC ACIDRelated Search:

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2-GUANIDINOETHYLMERCAPTOSUCCINIC ACID

GUANIDINOETHYLMERCAPTO-SUCCINIC ACID

GEMSA

(2-GUANIDINOETHYLMERCAPTO)SUCCINIC ACID 99+%

(2-Guanidinoethylthio)succinic acid, GEMSA

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2-[(2-Guanidinoethyl)thio]succinic acid

2-Guanidinoethylthiosuccinic acid

2-[(2-carbaMiMidaMidoethyl)sulfanyl]succinicacid

2-Guanidinoethylmercaptosuccinic Acid - CAS 77482-44-1 - Calbiochem

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2-Guanidinoethylmercaptosuccinic acid (GEMSA)

2-Guanidinoethylmercaptosuccinic acid (GEMSA), carboxypeptidase B2 (TAFIa) inhibitor

77482-44-1

C7H13N3O4S