2-GUANIDINOETHYLMERCAPTOSUCCINIC ACID
- Product Name
- 2-GUANIDINOETHYLMERCAPTOSUCCINIC ACID
- CAS No.
- 77482-44-1
- Chemical Name
- 2-GUANIDINOETHYLMERCAPTOSUCCINIC ACID
- Synonyms
- GEMSA;2-Guanidinoethylthiosuccinic acid;GUANIDINOETHYLMERCAPTO-SUCCINIC ACID;2-GUANIDINOETHYLMERCAPTOSUCCINIC ACID;2-(2-Guanidinoethylthio)succinic acid;2-[(2-Guanidinoethyl)thio]succinic acid;(2-Guanidinoethylthio)succinic acid, GEMSA;(2-GUANIDINOETHYLMERCAPTO)SUCCINIC ACID 99+%;2-Guanidinoethylmercaptosuccinic acid (GEMSA);2-[(2-carbaMiMidaMidoethyl)sulfanyl]succinicacid
- CBNumber
- CB3257755
- Molecular Formula
- C7H13N3O4S
- Formula Weight
- 235.26
- MOL File
- 77482-44-1.mol
2-GUANIDINOETHYLMERCAPTOSUCCINIC ACID Property
- Melting point:
- ~180 °C (dec.)
- storage temp.
- 2-8°C
- solubility
- Soluble in DMSO
- form
- White solid
- color
- white
- Water Solubility
- water: soluble
Safety
- Safety Statements
- 22-24/25
N-Bromosuccinimide Price
- Product number
- 369334
- Product name
- 2-Guanidinoethylmercaptosuccinic Acid
- Packaging
- 5mg
- Price
- $265
- Updated
- 2025/07/31
- Product number
- 19354
- Product name
- 2-Guanidinoethylmercaptosuccinic Acid
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $183
- Updated
- 2024/03/01
- Product number
- C3265
- Product name
- 2-Guanidinoethylmercaptosuccinic Acid
- Packaging
- 5mg
- Price
- $201
- Updated
- 2021/12/16
2-GUANIDINOETHYLMERCAPTOSUCCINIC ACID Chemical Properties,Usage,Production
Uses
GEMSA is a potent inhibitor of enkephalin convertase (Ki=8.8 nM). GEMSA elicites analgesia[1].
Biological Activity
ki: 8.8 nm2-guanidinoethylmercaptosuccinic acid is a carboxypeptidase e inhibitor.carboxypeptidase e, also known as enkephalin convertase, can remove c-terminal residues during the processing of propeptides, such as enkephalin and proinsulin.
in vitro
2-guanidinoethylmercaptosuccinic acid was identified as a biproduct analogs of lysine and arginine that showed potent inhibitory effect on enkephalin convertase with the ki value of 8.8 nm. in addition, 2-guanidinoethylmercaptosuccinic acid was found to be several hundred fold more potent towards enkephalin convertase than towards carboxypeptidase b or n and the kinetic analyses indicated the pure competitive nature of the inhibition [1].
in vivo
previous study found that following the intrathecal administration of 2-guanidinoethylmercaptosuccinic acid at 12.5, 25 and 50 micrograms, an increase in the tail-flick latency was seen. in addition, 2-guanidinoethylmercaptosuccinic acid could potentiate the analgesic effects of the intrathecally applied met5-enkephalin-arg6-phe7 and met5-enkephalin-arg6-gly7-leu8. all these effects of 2-guanidinoethylmercaptosuccinic acid were significantly attenuated by the treatment of naloxone. moreover, the rats subjected to chronic pain showed a weaker analgesic response to the treatment of 2-guanidinoethylmercaptosuccinic acid. furthermore, 2-guanidinoethylmercaptosuccinic acid bound to enkephalin convertase in the spinal cord of these rats produced only a slight increase in kd [2].
References
1. fricker ld, plummer th jr, snyder sh. enkephalin convertase: potent, selective, and irreversible inhibitors. biochem biophys res commun. 1983 mar 29;111(3):994-1000.2. m. bommer, k. nikolarakis, e. p. noble, et al. in vivo modulation of rat hypothalamic opioid peptide content by intracerebroventricular injection of guanidinoethylmercaptosuccinic acid (gemsa): possible physiological role of enkephalin convertase. brain research 492(1-2), 305-313 (1989).
2-GUANIDINOETHYLMERCAPTOSUCCINIC ACID Preparation Products And Raw materials
Raw materials
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