1-(6-Chloro-3-pyridazinyl)-4-piperidinol
- Product Name
- 1-(6-Chloro-3-pyridazinyl)-4-piperidinol
- CAS No.
- 89937-26-8
- Chemical Name
- 1-(6-Chloro-3-pyridazinyl)-4-piperidinol
- Synonyms
- 1-(6-CHLOROPYRIDAZIN-3-YL)PIPERIDIN-4-OL;1-(6-CHLORO-3-PYRIDAZINYL)-4-PIPERIDINOL;1-(6-Chloro-3-pyridazinyl)piperidin-4-ol;4-Piperidinol, 1-(6-chloro-3-pyridazinyl)-;1-(6-Chloropyridazin-3-yl)piperidin-4-ol95%;1-(6-Chloropyridazin-3-yl)-4-hydroxypiperidine;1-(6-Chloro-pyridazino-3-yl)-4-hydroxypiperidine;1-(6-Chloro-3-pyridazinyl)-4-piperidinol ISO 9001：2015 REACH
- CBNumber
- CB3258116
- Molecular Formula
- C9H12ClN3O
- Formula Weight
- 213.66
- MOL File
- 89937-26-8.mol
1-(6-Chloro-3-pyridazinyl)-4-piperidinol Property
- Boiling point:
- 453.3±45.0 °C(Predicted)
- Density
- 1.360±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- form
- solid
- pka
- 14.52±0.20(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- FC153681
- Product name
- 1-(6-Chloropyridazin-3-yl)piperidin-4-ol
- Packaging
- 1g
- Price
- $57
- Updated
- 2021/12/16
- Product number
- FC153681
- Product name
- 1-(6-Chloropyridazin-3-yl)piperidin-4-ol
- Packaging
- 2g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- W9271
- Product name
- 1-(6-Chloropyridazin-3-yl)piperidin-4-ol
- Packaging
- 1g
- Price
- $104
- Updated
- 2021/12/16
- Product number
- 071770
- Product name
- 1-(6-Chloropyridazin-3-yl)piperidin-4-ol
- Purity
- 95+%
- Packaging
- 1g
- Price
- $185
- Updated
- 2021/12/16
- Product number
- FC153681
- Product name
- 1-(6-Chloropyridazin-3-yl)piperidin-4-ol
- Packaging
- 5G
- Price
- $200
- Updated
- 2021/12/16
1-(6-Chloro-3-pyridazinyl)-4-piperidinol Chemical Properties,Usage,Production
Synthesis
5382-16-1
141-30-0
89937-26-8
General procedure: 3,6-dichloropyridazine (1 eq.), 4-hydroxypiperidine (1 eq.) and a nonprotonic base (e.g., Et3N or K2CO3, 2-3 eq.) are dissolved in DMSO or EtOH in a sealed vessel, and the reaction is heated until the feedstocks are shown to be completely consumed by TLC or HPLC monitoring. Upon completion of the reaction, post-treatment is carried out: the reaction mixture is partially evaporated, followed by the addition of water and filtration to collect the precipitated solid product (for cases such as 37); alternatively, the partially evaporated reaction mixture is partitioned between EtOAc and water, and the aqueous layer is extracted with EtOAc several times to ensure complete extraction. The organic layers are combined, dried over anhydrous Na2SO4 and concentrated under reduced pressure to give the crude product, which is finally purified by column chromatography.
References
[1] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 8, p. 1819 - 1839
[2] Patent: WO2016/54388, 2016, A1. Location in patent: Page/Page column 57
[3] Journal of Medicinal Chemistry, 1984, vol. 27, # 8, p. 1077 - 1083
[4] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 24, p. 7281 - 7286
[5] Patent: WO2008/46226, 2008, A1. Location in patent: Page/Page column 42
1-(6-Chloro-3-pyridazinyl)-4-piperidinol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-(6-Chloro-3-pyridazinyl)-4-piperidinol manufacturers
- Product
- 1-(6-Chloropyridazin-3-yl)piperidin-4-ol 89937-26-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-04-29
- Product
- 1-(6-Chloro-3-pyridazinyl)-4-piperidinol 89937-26-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-11-02
- Product
- 1-(6-Chloro-3-pyridazinyl)-4-piperidinol 89937-26-8
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 98%; 99%
- Supply Ability
- 1kg; 10kg; 25kg
- Release date
- 2020-01-07