ChemicalBook > CAS DataBase List > JZL 195

JZL 195

Product Name
JZL 195
CAS No.
1210004-12-8
Chemical Name
JZL 195
Synonyms
CS-1586;JZL 195;JZL-195;JZL 195;JZL195;4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carboxylate;4-Nitrophenyl 4-[(3-phenoxyphenyl)methyl]-1-piperazinecarboxylate;4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylic acid 4-nitrophenyl ester;1-Piperazinecarboxylic acid, 4-[(3-phenoxyphenyl)methyl]-, 4-nitrophenyl ester;Autophagy,Monoacylglycerol lipase,inhibit,MAGL,Fatty acid amide hydrolase,JZL-195,JZL195,Inhibitor,FAAH,JZL 195
CBNumber
CB32591530
Molecular Formula
C24H23N3O5
Formula Weight
433.46
MOL File
1210004-12-8.mol
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JZL 195 Property

Boiling point:
581.8±50.0 °C(Predicted)
Density 
1.303±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO: ≥5mg/mL at warmed
pka
6.13±0.10(Predicted)
form 
powder
color 
white to beige
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Safety

Hazard Codes 
N
Risk Statements 
50
Safety Statements 
61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0257
Product name
JZL195
Purity
≥98% (HPLC)
Packaging
5mg
Price
$127
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0257
Product name
JZL195
Purity
≥98% (HPLC)
Packaging
25mg
Price
$491
Updated
2024/03/01
Cayman Chemical
Product number
13668
Product name
JZL 195
Purity
≥98%
Packaging
5mg
Price
$61
Updated
2024/03/01
Cayman Chemical
Product number
13668
Product name
JZL 195
Purity
≥98%
Packaging
10mg
Price
$112
Updated
2024/03/01
Cayman Chemical
Product number
13668
Product name
JZL 195
Purity
≥98%
Packaging
50mg
Price
$468
Updated
2024/03/01
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JZL 195 Chemical Properties,Usage,Production

Description

Fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) mediate the hydrolysis of the endocannabinoids arachidonoyl ethanolamide (AEA) and 2-arachidonoylglycerol (2-AG), respectively. JZL 195 is a potent inhibitor of both FAAH and MAGL (IC50s = 2 and 4 nM, respectively). It poorly inhibits neuropathy target esterase and ABHD6 and does not inhibit other brain serine hydrolases. JZL 195 displays time-dependent inhibition of FAAH and MAGL in vivo, consistent with a covalent mechanism of activation. The in vivo inhibitory actions of JZL 195 against FAAH and MAGL are comparable to those of the selective inhibitors PF-3845 and JZL 184 , respectively. Through its inhibitory actions, JZL 195 simultaneously augments brain levels of AEA and 2-AG, producing antinociceptive, cataleptic, and hypomotility effects like those produced by direct CB1 agonists.

Uses

JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor with IC50 of 13 nM and 19 nM for mouse brain FAAH and MAGL respectively.

storage

Store at -20°C

JZL 195 Preparation Products And Raw materials

Raw materials

Preparation Products

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JZL 195 Suppliers

China 65 United Kingdom 1 United States 14 Global 80
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View Lastest Price from JZL 195 manufacturers

Career Henan Chemical Co
Product
JZL 195 1210004-12-8
Price
US $1.00/KG
Min. Order
1KG
Purity
97%-99.9%
Supply Ability
100kg
Release date
2020-03-05

1210004-12-8, JZL 195Related Search:


  • JZL 195
  • 4-nitrophenyl 4-(3-phenoxybenzyl)piperazine-1-carboxylate
  • 4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylic acid 4-nitrophenyl ester
  • CS-1586
  • JZL-195;JZL 195;JZL195
  • 1-Piperazinecarboxylic acid, 4-[(3-phenoxyphenyl)methyl]-, 4-nitrophenyl ester
  • 4-Nitrophenyl 4-[(3-phenoxyphenyl)methyl]-1-piperazinecarboxylate
  • Autophagy,Monoacylglycerol lipase,inhibit,MAGL,Fatty acid amide hydrolase,JZL-195,JZL195,Inhibitor,FAAH,JZL 195
  • 1210004-12-8
  • Inhibitors
  • API