VER-50589

Product Name: VER-50589
CAS No.: 747413-08-7
Chemical Name: VER-50589
Synonyms: CS-2576;VER-50589;VER 50589;VER50589;VER-50589 USP/EP/BP;Apoptosis,VER-50589,HSP,VER 50589,Inhibitor,Heat shock proteins,inhibit;5-(5-Chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)-3-isoxazolecarboxamide;5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-Methoxyphenyl)isoxazole-3-carboxaMide;3-Isoxazolecarboxamide, 5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)-
CBNumber: CB32592830
Molecular Formula: C19H17ClN2O5
Formula Weight: 388.8
MOL File: 747413-08-7.mol

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VER-50589 Property

Boiling point:: 583.0±50.0 °C(Predicted)
Density: 1.360±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥38.9 mg/mL in DMSO; insoluble in H2O; ≥57.2 mg/mL in EtOH
form: solid
pka: 7.12±0.25(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 13132
Product name: VER-50589
Purity: ≥98%
Packaging: 500μg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 13132
Product name: VER-50589
Purity: ≥98%
Packaging: 1mg
Price: $92
Updated: 2024/03/01

Cayman Chemical

Product number: 13132
Product name: VER-50589
Purity: ≥98%
Packaging: 5mg
Price: $356
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: INB0001085
Product name: 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)-3-ISOXAZOLECARBOXAMIDE
Purity: 95.00%
Packaging: 5MG
Price: $499.82
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 49200
Product name: VER-50589
Packaging: 5mg
Price: $830
Updated: 2021/12/16

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VER-50589 Chemical Properties,Usage,Production

Uses

VER-50589 inhibits the intrinsic ATPase activity of recombinant yeast Hsp90. It produces antiproliferative activity in a panel of human cancer cell lines and nontumorigenic cells in vitro.

Biological Activity

ver-50589 is a potent inhibitor of hsp90 with ic50 value of 21 nm for hsp90β [1].heat shock protein 90 (hsp90) is a chaperone protein that stabilizes proteins against heat stress, assists proteins to fold properly and aids in protein degradation. also, hsp90 stabilizes proteins required for tumor growth.ver-50589 is a potent hsp90 inhibitor. ver-50589 inhibited recombinant yeast hsp90 atpase activity with ic50 value of 143 nm at 400 μm atp and inhibited recombinant human hsp90β with ic50 value of 821 nm in the presence of the activator aha1. also, ver-50589 bound to recombinant human hsp90β with kd value of 4.5 nm. in human cancer cells, ver-50589 exhibited antiproliferative activity with mean gi50 value of 78 nm. in ch1 human ovarian cells, ver-50589 inhibited cell growth with gi50 value of 32.7 nm. in ht29 cells, ver-50589 exhibited extensive glucuronidation and increased glucuronide levels by 50-fold, which were responsible for the resistance. in ch1doxr cells that were resistant to doxorubicin, ver-50589 exhibited similar cellular gi50 value compared with ch1 cells. in hct116 colon cancer cells, ver-50589 caused g1 and g2-m block. also, ver-50589 induced cytostasis and apoptosis [1].in athymic mice bearing ovcar3 human ovarian ascites tumors, ver-50589 completely inhibited hsp90. in mice bearing hct116 colon carcinoma xenografts, ver-50589 (100 mg/kg) reduced tumor volume by 30% and tumor weight by 26%. also, ver-50589 reduced expression of erbb2 and c-raf [1].

target

HSP90β

References

[1]. sharp sy, prodromou c, boxall k, et al. inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues. mol cancer ther, 2007, 6(4): 1198-1211.

VER-50589 Preparation Products And Raw materials

Raw materials

Preparation Products

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VER-50589 Suppliers

China 64 India 1 United States 13 Global 78

MedChemexpress LLC

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Target molecule Corp.

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Musechem

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TargetMol Chemicals Inc.

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InvivoChem

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Cckinase, Inc.

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Aladdin Scientific

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ApexBio Technology

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BOC Sciences

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Cayman Chemical Company

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United States Biological

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Selleck Chemicals LLC

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Santa Cruz Biotechnology, Inc.

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747413-08-7, VER-50589Related Search:

VER-246608 VER-49009 5'-O-[(4-Cyanophenyl)methyl]-8-[[(3,4-dichlorophenyl)methyl]amino]-adenosine CH5138303

VER-50589

5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-Methoxyphenyl)isoxazole-3-carboxaMide

VER 50589;VER50589

CS-2576

5-(5-Chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)-3-isoxazolecarboxamide

3-Isoxazolecarboxamide, 5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)-

VER-50589 USP/EP/BP

Apoptosis,VER-50589,HSP,VER 50589,Inhibitor,Heat shock proteins,inhibit

747413-08-7

Inhibitors

API