ChemicalBook > CAS DataBase List > 3-(2-chloropyriMidin-4-yl)-1H-indole

3-(2-chloropyriMidin-4-yl)-1H-indole

Application Application

Product Name: 3-(2-chloropyriMidin-4-yl)-1H-indole
CAS No.: 945016-63-7
Chemical Name: 3-(2-chloropyriMidin-4-yl)-1H-indole
Synonyms: 3-(2-Chloro-4-pyrimidyl)indole;3-(2-Chloro-4-pyrimidinyl)-1H-indole;3-(2-chloropyriMidin-4-yl)-1H-indole;1H-Indole, 3-(2-chloro-4-pyrimidinyl)-
CBNumber: CB32595543
Molecular Formula: C12H8ClN3
Formula Weight: 229.66
MOL File: 945016-63-7.mol

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3-(2-chloropyriMidin-4-yl)-1H-indole Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Appearance: Light yellow to yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-D1258
Product name: 3-(2-chloropyriMidin-4-yl)-1H-indole
Packaging: 250mg
Price: $57
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0364016
Product name: 3-(2-CHLOROPYRIMIDIN-4-YL)-1H-INDOLE
Purity: 95.00%
Packaging: 5MG
Price: $499.65
Updated: 2021/12/16

ChemScene

Product number: CS-D1258
Product name: 3-(2-chloropyriMidin-4-yl)-1H-indole
Packaging: 5g
Price: $551
Updated: 2021/12/16

ChemScene

Product number: CS-D1258
Product name: 3-(2-chloropyriMidin-4-yl)-1H-indole
Packaging: 10g
Price: $939
Updated: 2021/12/16

Chemenu

Product number: CM148712
Product name: 3-(2-chloropyrimidin-4-yl)-1H-indole
Purity: 95%+
Packaging: 25g
Price: $1104
Updated: 2021/12/16

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3-(2-chloropyriMidin-4-yl)-1H-indole Chemical Properties,Usage,Production

Application

3-(2-Chloro-pyrimidin-4-yl)-1H-indole can be used as an organic synthesis intermediate and a pharmaceutical intermediate, mainly in laboratory research and development processes and chemical and pharmaceutical synthesis processes.

Application

2,3,4-Trimethoxybenzaldehyde is an important pharmaceutical intermediate used in the synthesis of novel Ca2+ channel blockers. This drug can selectively target cerebral arteries to reduce the incidence of headaches and has a certain market demand in Europe and the United States. It can also be used as impurity C in trimetazidine, contributing to the standardization process during trimetazidine development. Impurity research is a crucial aspect of drug development.

Synthesis

120-72-9

3934-20-1

945016-63-7

General procedure for the synthesis of 3-(2-chloropyrimidin-4-yl)-1H-indole from indole and 2,4-dichloropyrimidine: 3-(2-chloropyrimidin-4-yl)-1H-indole (1 g, 4.37 mmol), 2-(difluoromethoxy)-4-fluoro-5-nitroaniline (810 mg, 4.37 mmol), and p-toluenesulfonic acid (750 mg, 4.37 mmol) were dissolved in 2-pentanol (40 mL). The reaction mixture was heated and stirred at 110 °C for 3 hours. The progress of the reaction was monitored by LCMS and after confirming the completion of the reaction, the reaction mixture was naturally cooled to room temperature and a dark colored solid was precipitated. The solid was collected by filtration and the filter cake was washed sequentially with methanol and methyl tert-butyl ether to give 3-(2-chloropyrimidin-4-yl)-1H-indole (1.3 g, 79% yield).

References

[1] Patent: EP3205650, 2017, A1. Location in patent: Paragraph 0106; 0512; 0513
[2] Journal of Medicinal Chemistry, 2013, vol. 56, # 17, p. 7025 - 7048
[3] Patent: CN105153122, 2018, B. Location in patent: Paragraph 0034; 0117; 0118; 0119; 0120
[4] Patent: WO2013/14448, 2013, A1. Location in patent: Page/Page column 139
[5] Journal of Medicinal Chemistry, 2014, vol. 57, # 20, p. 8249 - 8267

3-(2-chloropyriMidin-4-yl)-1H-indole Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-(2-chloropyriMidin-4-yl)-1H-indole manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 3-(2-chloropyriMidin-4-yl)-1H-indole
Price: US $150.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500kg
Release date: 2024-11-13

Career Henan Chemical Co

Product: 3-(2-chloropyriMidin-4-yl)-1H-indole 945016-63-7
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2019-12-25

945016-63-7, 3-(2-chloropyriMidin-4-yl)-1H-indoleRelated Search:

3-(2-chloropyriMidin-4-yl)-1H-indole

3-(2-Chloro-4-pyrimidinyl)-1H-indole

1H-Indole, 3-(2-chloro-4-pyrimidinyl)-

3-(2-Chloro-4-pyrimidyl)indole

945016-63-7