3-(2-chloropyriMidin-4-yl)-1H-indole
Application Application- Product Name
- 3-(2-chloropyriMidin-4-yl)-1H-indole
- CAS No.
- 945016-63-7
- Chemical Name
- 3-(2-chloropyriMidin-4-yl)-1H-indole
- Synonyms
- 3-(2-Chloro-4-pyrimidyl)indole;3-(2-Chloro-4-pyrimidinyl)-1H-indole;3-(2-chloropyriMidin-4-yl)-1H-indole;1H-Indole, 3-(2-chloro-4-pyrimidinyl)-
- CBNumber
- CB32595543
- Molecular Formula
- C12H8ClN3
- Formula Weight
- 229.66
- MOL File
- 945016-63-7.mol
3-(2-chloropyriMidin-4-yl)-1H-indole Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- Light yellow to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-D1258
- Product name
- 3-(2-chloropyriMidin-4-yl)-1H-indole
- Packaging
- 250mg
- Price
- $57
- Updated
- 2021/12/16
- Product number
- HCH0364016
- Product name
- 3-(2-CHLOROPYRIMIDIN-4-YL)-1H-INDOLE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $499.65
- Updated
- 2021/12/16
- Product number
- CS-D1258
- Product name
- 3-(2-chloropyriMidin-4-yl)-1H-indole
- Packaging
- 5g
- Price
- $551
- Updated
- 2021/12/16
- Product number
- CS-D1258
- Product name
- 3-(2-chloropyriMidin-4-yl)-1H-indole
- Packaging
- 10g
- Price
- $939
- Updated
- 2021/12/16
- Product number
- CM148712
- Product name
- 3-(2-chloropyrimidin-4-yl)-1H-indole
- Purity
- 95%+
- Packaging
- 25g
- Price
- $1104
- Updated
- 2021/12/16
3-(2-chloropyriMidin-4-yl)-1H-indole Chemical Properties,Usage,Production
Application
3-(2-Chloro-pyrimidin-4-yl)-1H-indole can be used as an organic synthesis intermediate and a pharmaceutical intermediate, mainly in laboratory research and development processes and chemical and pharmaceutical synthesis processes.
Application
2,3,4-Trimethoxybenzaldehyde is an important pharmaceutical intermediate used in the synthesis of novel Ca2+ channel blockers. This drug can selectively target cerebral arteries to reduce the incidence of headaches and has a certain market demand in Europe and the United States. It can also be used as impurity C in trimetazidine, contributing to the standardization process during trimetazidine development. Impurity research is a crucial aspect of drug development.
Synthesis
120-72-9
3934-20-1
945016-63-7
General procedure for the synthesis of 3-(2-chloropyrimidin-4-yl)-1H-indole from indole and 2,4-dichloropyrimidine: 3-(2-chloropyrimidin-4-yl)-1H-indole (1 g, 4.37 mmol), 2-(difluoromethoxy)-4-fluoro-5-nitroaniline (810 mg, 4.37 mmol), and p-toluenesulfonic acid (750 mg, 4.37 mmol) were dissolved in 2-pentanol (40 mL). The reaction mixture was heated and stirred at 110 °C for 3 hours. The progress of the reaction was monitored by LCMS and after confirming the completion of the reaction, the reaction mixture was naturally cooled to room temperature and a dark colored solid was precipitated. The solid was collected by filtration and the filter cake was washed sequentially with methanol and methyl tert-butyl ether to give 3-(2-chloropyrimidin-4-yl)-1H-indole (1.3 g, 79% yield).
References
[1] Patent: EP3205650, 2017, A1. Location in patent: Paragraph 0106; 0512; 0513
[2] Journal of Medicinal Chemistry, 2013, vol. 56, # 17, p. 7025 - 7048
[3] Patent: CN105153122, 2018, B. Location in patent: Paragraph 0034; 0117; 0118; 0119; 0120
[4] Patent: WO2013/14448, 2013, A1. Location in patent: Page/Page column 139
[5] Journal of Medicinal Chemistry, 2014, vol. 57, # 20, p. 8249 - 8267
3-(2-chloropyriMidin-4-yl)-1H-indole Preparation Products And Raw materials
Raw materials
Preparation Products
3-(2-chloropyriMidin-4-yl)-1H-indole Suppliers
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View Lastest Price from 3-(2-chloropyriMidin-4-yl)-1H-indole manufacturers
- Product
- 3-(2-chloropyriMidin-4-yl)-1H-indole
- Price
- US $150.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 500kg
- Release date
- 2024-11-13
- Product
- 3-(2-chloropyriMidin-4-yl)-1H-indole 945016-63-7
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2019-12-25