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5-(TrifluoroMethyl)benzoxazole

Product Name
5-(TrifluoroMethyl)benzoxazole
CAS No.
1267217-46-8
Chemical Name
5-(TrifluoroMethyl)benzoxazole
Synonyms
5-(TrifluoroMethyl)benzoxazole;Benzoxazole, 5-(trifluoromethyl)-;5-(TrifluoroMethyl)benzo[d]oxazole;5-(trifluoromethyl)-1,3-benzoxazole;5-(Trifluoromethyl)-1,3-benzoxazole95%;5-(Trifluoromethyl)-1,3-benzoxazole 95%
CBNumber
CB32596944
Molecular Formula
C8H4F3NO
Formula Weight
187.12
MOL File
1267217-46-8.mol
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5-(TrifluoroMethyl)benzoxazole Property

Melting point:
43-44 °C(Solv: hexane (110-54-3))
Boiling point:
195.6±35.0 °C(Predicted)
Density 
1.406±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
-3.31±0.10(Predicted)
Appearance
Colorless to light yellow Liquid
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Safety

HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
T897655
Product name
5-(Trifluoromethyl)benzoxazole
Packaging
100mg
Price
$65
Updated
2021/12/16
TRC
Product number
T897655
Product name
5-(Trifluoromethyl)benzoxazole
Packaging
500mg
Price
$240
Updated
2021/12/16
Apolloscientific
Product number
PC300509
Product name
5-(Trifluoromethyl)-1,3-benzoxazole
Purity
95%
Packaging
250mg
Price
$50
Updated
2021/12/16
SynQuest Laboratories
Product number
4H56-3-N1
Product name
5-(Trifluoromethyl)-1,3-benzoxazole
Purity
95%
Packaging
250mg
Price
$80
Updated
2021/12/16
Apolloscientific
Product number
PC300509
Product name
5-(Trifluoromethyl)-1,3-benzoxazole
Purity
95%
Packaging
1g
Price
$150
Updated
2021/12/16
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5-(TrifluoroMethyl)benzoxazole Chemical Properties,Usage,Production

Synthesis

400-99-7

122-51-0

1267217-46-8

The general procedure for the synthesis of 5-trifluoromethylbenzoxazole from 2-nitro-4-trifluoromethylphenol and triethyl orthoformate was as follows: 2-nitro-4-(trifluoromethyl)phenol (500 mg, 2.41 mmol) and a palladium/carbon catalyst (200 mg) were added to ethanol (10 ml) at 0 °C and under argon protection. After hydrogen was passed to replace the air in the reaction system, the reaction was stirred at room temperature overnight. Upon completion of the reaction, the catalyst was removed by diatomaceous earth filtration and the filtrate was concentrated under reduced pressure. To the concentrated residue, triethyl orthoformate (2.4 ml, 14.5 mmol) was added and p-toluenesulfonic acid monohydrate (23 mg, 0.12 mmol) was added dropwise as a catalyst. The reaction mixture was heated to reflux and stirred for 3 hours under argon protection. Upon completion of the reaction, the reaction solution was concentrated to dryness. The resulting crude product was purified by silica gel column chromatography (eluent: hexane/ethyl acetate) to give 5-trifluoromethylbenzoxazole (182 mg, 40% yield).

References

[1] Patent: JP2016/124812, 2016, A. Location in patent: Paragraph 0108

5-(TrifluoroMethyl)benzoxazole Preparation Products And Raw materials

Raw materials

Preparation Products

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5-(TrifluoroMethyl)benzoxazole Suppliers

China 33 India 1 United Kingdom 1 United States 6 Global 41
Accela ChemBio Inc.
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+1(858) 699-3322
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+1(858) 876-1948
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marketing@accelachem.com
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Accela ChemBio Inc.
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+1-858-6993322
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(+1)-858-876-1948
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United States
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Alchem Pharmtech,Inc.
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sales@alchempharmtech.com
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United States
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Aceschem Inc.
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+1-817863-6948 +1-（817）863-6948
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sales@aceschem.com
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Synthonix Inc
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info@synthonix.com
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United States
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SynQuest Laboratories, Inc.
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Email
info@synquestlabs.com
Country
United States
ProdList
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