ChemicalBook > CAS DataBase List > EGFR inhibitor

EGFR inhibitor

Product Name: EGFR inhibitor
CAS No.: 879127-07-8
Chemical Name: EGFR inhibitor
Synonyms: EGFR-IN-12;EGFR inhibitor;EGFR inhibitor 324674;EGFR inhibitor(YUN27078);EGFR-IN-12, 10 mM in DMSO;EGFR-IN-12 (EGFR Inhibitor);EGFR Inhibitor [879127-07-8];EGFR Inhibitor [879127-07-8] - EGFR Inhibitor 324674;N-(3-((6-((3-(Trifluoromethyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)cyclopropanecarboxamide;CyclopropanecarboxaMide, N-[3-[[6-[[3-(trifluoroMethyl)phenyl]aMino]-4-pyriMidinyl]aMino]phenyl]-
CBNumber: CB32597567
Molecular Formula: C21H18F3N5O
Formula Weight: 413.4
MOL File: 879127-07-8.mol

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EGFR inhibitor Property

Boiling point:: 605.9±55.0 °C(Predicted)
Density: 1.456±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in H2O; insoluble in EtOH; ≥60.7 mg/mL in DMSO
form: crystalline solid
pka: 14.50±0.70(Predicted)
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 324674
Product name: EGFR Inhibitor - CAS 879127-07-8 - Calbiochem
Packaging: 1MG
Price: $139
Updated: 2025/07/31

Cayman Chemical

Product number: 15363
Product name: EGFR Inhibitor
Purity: ≥98%
Packaging: 1mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 15363
Product name: EGFR Inhibitor
Purity: ≥98%
Packaging: 5mg
Price: $275
Updated: 2024/03/01

Cayman Chemical

Product number: 15363
Product name: EGFR Inhibitor
Purity: ≥98%
Packaging: 25mg
Price: $957
Updated: 2024/03/01

TRC

Product number: E440158
Product name: EGFRInhibitor
Packaging: 1mg
Price: $115
Updated: 2021/12/16

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EGFR inhibitor Chemical Properties,Usage,Production

Uses

EGFR Inhibitor is a highly selective, cell-permeable EGFR inhibitor.

Biological Activity

egfr inhibitor is a cell permeable, pyrimidine compound that selectively inhibits the egfr kinase with ic50 value of 21 nm [1].egfr is a transmembrane protein, and is a receptor for members of epidermal growth factor family. the binding of egfr with its ligands induces receptor dimerization and tyrosine autophosphorylation, and leads to cell proliferation. the overactivity of egfr tyrosine kinases is associated with a number of cancers, inhibition of egfr can downregulate antiapoptotic proteins such as surviving and upregulate proapoptotic proteins such as bim. thus, egfr inhibitor can induce cell apoptosis, resulting in anti-tumor effectivity [2].egfr inhibitor inhibited egfr kinase in vitro and blocks receptor autophosphorylation in cells. egfr inhibitor also inhibited l858r and l861q egfr mutants with ic50 values of 63 and 4 nm, respectively [1].

IC 50

EGFR (WT): 21 nM (IC₅₀); EGFR^L858R: 63 nM (IC₅₀); EGFR^L861Q: 4 nM (IC₅₀); HER4: 7640 nM (IC₅₀)

References

1. q. zhang, y. liu, f. gao, et al. discovery of egfr selective 4,6-disubstituted pyrimidines from a combinatorial kinase-directed heterocycle library. journal of the american chemical society 128(7), 2182-2183 (2006). 2. f. ciardiello, g. tortora. egfr antagonists in cancer treatment. new england journal of medicine 358(11), 1160-1174 (2008).

EGFR inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

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879127-07-8, EGFR inhibitorRelated Search:

EGFR inhibitor

CyclopropanecarboxaMide, N-[3-[[6-[[3-(trifluoroMethyl)phenyl]aMino]-4-pyriMidinyl]aMino]phenyl]-

EGFR Inhibitor [879127-07-8]

EGFR-IN-12

EGFR inhibitor 324674

EGFR inhibitor(YUN27078)

EGFR Inhibitor [879127-07-8] - EGFR Inhibitor 324674

N-(3-((6-((3-(Trifluoromethyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)cyclopropanecarboxamide

EGFR,EGFRIN12,autophosphorylation,anti-proliferation,4,6-disubstituted,antitumor,kinases,Epidermal growth factor receptor,inhibit,EGFR IN 12,AKT,pyrimidine,ErbB-1,Apoptosis,Inhibitor,HER1,Tyrosine

EGFR-IN-12, 10 mM in DMSO

EGFR-IN-12 (EGFR Inhibitor)

879127-07-8

A EGFR tyrosine kinase inhibitor.