EGFR inhibitor
- Product Name
- EGFR inhibitor
- CAS No.
- 879127-07-8
- Chemical Name
- EGFR inhibitor
- Synonyms
- EGFR-IN-12;EGFR inhibitor;EGFR inhibitor 324674;EGFR inhibitor(YUN27078);EGFR Inhibitor [879127-07-8];EGFR Inhibitor [879127-07-8] - EGFR Inhibitor 324674;N-(3-((6-((3-(Trifluoromethyl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)cyclopropanecarboxamide;CyclopropanecarboxaMide, N-[3-[[6-[[3-(trifluoroMethyl)phenyl]aMino]-4-pyriMidinyl]aMino]phenyl]-;EGFR,EGFRIN12,autophosphorylation,anti-proliferation,4,6-disubstituted,antitumor,kinases,Epidermal growth factor receptor,inhibit,EGFR IN 12,AKT,pyrimidine,ErbB-1,Apoptosis,Inhibitor,HER1,Tyrosine
- CBNumber
- CB32597567
- Molecular Formula
- C21H18F3N5O
- Formula Weight
- 413.4
- MOL File
- 879127-07-8.mol
EGFR inhibitor Property
- Boiling point:
- 605.9±55.0 °C(Predicted)
- Density
- 1.456±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- insoluble in H2O; insoluble in EtOH; ≥60.7 mg/mL in DMSO
- form
- crystalline solid
- pka
- 14.50±0.70(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 324674
- Product name
- EGFR Inhibitor - CAS 879127-07-8 - Calbiochem
- Packaging
- 1MG
- Price
- $159
- Updated
- 2024/03/01
- Product number
- 15363
- Product name
- EGFR Inhibitor
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 15363
- Product name
- EGFR Inhibitor
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $275
- Updated
- 2024/03/01
- Product number
- 15363
- Product name
- EGFR Inhibitor
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $957
- Updated
- 2024/03/01
- Product number
- E440158
- Product name
- EGFRInhibitor
- Packaging
- 1mg
- Price
- $115
- Updated
- 2021/12/16
EGFR inhibitor Chemical Properties,Usage,Production
Uses
EGFR Inhibitor is a highly selective, cell-permeable EGFR inhibitor.
Biological Activity
egfr inhibitor is a cell permeable, pyrimidine compound that selectively inhibits the egfr kinase with ic50 value of 21 nm [1].egfr is a transmembrane protein, and is a receptor for members of epidermal growth factor family. the binding of egfr with its ligands induces receptor dimerization and tyrosine autophosphorylation, and leads to cell proliferation. the overactivity of egfr tyrosine kinases is associated with a number of cancers, inhibition of egfr can downregulate antiapoptotic proteins such as surviving and upregulate proapoptotic proteins such as bim. thus, egfr inhibitor can induce cell apoptosis, resulting in anti-tumor effectivity [2].egfr inhibitor inhibited egfr kinase in vitro and blocks receptor autophosphorylation in cells. egfr inhibitor also inhibited l858r and l861q egfr mutants with ic50 values of 63 and 4 nm, respectively [1].
References
1. q. zhang, y. liu, f. gao, et al. discovery of egfr selective 4,6-disubstituted pyrimidines from a combinatorial kinase-directed heterocycle library. journal of the american chemical society 128(7), 2182-2183 (2006). 2. f. ciardiello, g. tortora. egfr antagonists in cancer treatment. new england journal of medicine 358(11), 1160-1174 (2008).