2,4,6-trichloro-3-nitropyridine

Product Name: 2,4,6-trichloro-3-nitropyridine
CAS No.: 60186-13-2
Chemical Name: 2,4,6-trichloro-3-nitropyridine
Synonyms: 2,4,6-TRICHLORO-3-NITROPYRIDINE;Pyridine, 2,4,6-trichloro-3-nitro-
CBNumber: CB32605969
Molecular Formula: C5HCl3N2O2
Formula Weight: 227.43
MOL File: 60186-13-2.mol

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2,4,6-trichloro-3-nitropyridine Property

Melting point:: 65 °C(Solv: heptane (142-82-5))
Boiling point:: 317.8±37.0 °C(Predicted)
Density: 1.744±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -5.55±0.10(Predicted)
Appearance: Off-white to yellow Solid

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: T774403
Product name: 2,4,6-Trichloro-3-nitropyridine
Packaging: 500mg
Price: $240
Updated: 2021/12/16

AK Scientific

Product number: 4744CT
Product name: 2,4,6-Trichloro-3-nitropyridine
Packaging: 1g
Price: $288
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0362619
Product name: 2,4,6-TRICHLORO-3-NITROPYRIDINE
Purity: 95.00%
Packaging: 5MG
Price: $502.71
Updated: 2021/12/16

AK Scientific

Product number: 4744CT
Product name: 2,4,6-Trichloro-3-nitropyridine
Packaging: 25g
Price: $2120
Updated: 2021/12/16

Alichem

Product number: 60186132
Product name: 2,4,6-Trichloro-3-nitropyridine
Packaging: 5g
Price: $502.9
Updated: 2021/12/16

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2,4,6-trichloro-3-nitropyridine Chemical Properties,Usage,Production

Uses

2,?4,?6-?Trichloro-?3-?nitropyridine is a reagent in the synthesis of Imigliptin, a DPP-4 inhibitor used in the treatment of type 2 diabetes.

Synthesis

2897-43-0

60186-13-2

General procedure for the synthesis of 2,4,6-trichloro-3-nitropyridine from 4-amino-2,6-dichloro-3-nitropyridine: (6) 2,6-dichloro-3-nitropyridin-4-amine (2.27 g, 10.9 mmol) was added to 48 mL of concentrated hydrochloric acid and the mixture was cooled to 0-5 °C. Sodium nitrite (2.26 g, 32.7 mmol) was added to the solution in batches with stirring. After the sodium nitrite was added, the reaction mixture was continued to be stirred at 0-5 °C for 1 h, and then raised to 25 °C for 2 h. The reaction mixture was then stirred for 1 h. The reaction was then stirred for 2 h. The reaction mixture was then stirred for 2 h. After completion of the reaction, the reaction solution was adjusted to pH=7 with 40% sodium hydroxide solution and then extracted with ether. The organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure. The resulting crude product was eluted with petroleum ether to give 2 g of white solid product in 80.7% yield.

References

[1] Patent: US2012/289497, 2012, A1. Location in patent: Page/Page column 51; 53
[2] Patent: EP2524917, 2012, A1. Location in patent: Page/Page column 58; 60
[3] ACS Medicinal Chemistry Letters, 2014, vol. 5, # 8, p. 921 - 926

2,4,6-trichloro-3-nitropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4,6-trichloro-3-nitropyridine Suppliers

China 39 India 1 United States 4 Global 44

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View Lastest Price from 2,4,6-trichloro-3-nitropyridine manufacturers

Career Henan Chemical Co

Product: 2,4,6-trichloro-3-nitropyridine 60186-13-2
Price: US $1.00/KG
Min. Order: 1g
Purity: 99.0%
Supply Ability: 100kg
Release date: 2020-01-10

60186-13-2, 2,4,6-trichloro-3-nitropyridineRelated Search:

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Pyridine, 2,4,6-trichloro-3-nitro-

2,4,6-TRICHLORO-3-NITROPYRIDINE

60186-13-2