ChemicalBook > CAS DataBase List > 2,4,6-trichloro-3-nitropyridine

2,4,6-trichloro-3-nitropyridine

Product Name
2,4,6-trichloro-3-nitropyridine
CAS No.
60186-13-2
Chemical Name
2,4,6-trichloro-3-nitropyridine
Synonyms
2,4,6-TRICHLORO-3-NITROPYRIDINE;Pyridine, 2,4,6-trichloro-3-nitro-
CBNumber
CB32605969
Molecular Formula
C5HCl3N2O2
Formula Weight
227.43
MOL File
60186-13-2.mol
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2,4,6-trichloro-3-nitropyridine Property

Melting point:
65 °C(Solv: heptane (142-82-5))
Boiling point:
317.8±37.0 °C(Predicted)
Density 
1.744±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-5.55±0.10(Predicted)
Appearance
Off-white to yellow Solid
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
T774403
Product name
2,​4,​6-​Trichloro-​3-​nitropyridine
Packaging
500mg
Price
$240
Updated
2021/12/16
AK Scientific
Product number
4744CT
Product name
2,4,6-Trichloro-3-nitropyridine
Packaging
1g
Price
$288
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0362619
Product name
2,4,6-TRICHLORO-3-NITROPYRIDINE
Purity
95.00%
Packaging
5MG
Price
$502.71
Updated
2021/12/16
AK Scientific
Product number
4744CT
Product name
2,4,6-Trichloro-3-nitropyridine
Packaging
25g
Price
$2120
Updated
2021/12/16
Alichem
Product number
60186132
Product name
2,4,6-Trichloro-3-nitropyridine
Packaging
5g
Price
$502.9
Updated
2021/12/16
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2,4,6-trichloro-3-nitropyridine Chemical Properties,Usage,Production

Uses

2,?4,?6-?Trichloro-?3-?nitropyridine is a reagent in the synthesis of Imigliptin, a DPP-4 inhibitor used in the treatment of type 2 diabetes.

Synthesis

2897-43-0

60186-13-2

General procedure for the synthesis of 2,4,6-trichloro-3-nitropyridine from 4-amino-2,6-dichloro-3-nitropyridine: (6) 2,6-dichloro-3-nitropyridin-4-amine (2.27 g, 10.9 mmol) was added to 48 mL of concentrated hydrochloric acid and the mixture was cooled to 0-5 °C. Sodium nitrite (2.26 g, 32.7 mmol) was added to the solution in batches with stirring. After the sodium nitrite was added, the reaction mixture was continued to be stirred at 0-5 °C for 1 h, and then raised to 25 °C for 2 h. The reaction mixture was then stirred for 1 h. The reaction was then stirred for 2 h. The reaction mixture was then stirred for 2 h. After completion of the reaction, the reaction solution was adjusted to pH=7 with 40% sodium hydroxide solution and then extracted with ether. The organic phases were combined, dried with anhydrous sodium sulfate and concentrated under reduced pressure. The resulting crude product was eluted with petroleum ether to give 2 g of white solid product in 80.7% yield.

References

[1] Patent: US2012/289497, 2012, A1. Location in patent: Page/Page column 51; 53
[2] Patent: EP2524917, 2012, A1. Location in patent: Page/Page column 58; 60
[3] ACS Medicinal Chemistry Letters, 2014, vol. 5, # 8, p. 921 - 926

2,4,6-trichloro-3-nitropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2,4,6-trichloro-3-nitropyridine Suppliers

China 39 India 1 United States 4 Global 44
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
Advantage
58
Synthonix Inc
Tel
--
Fax
--
Email
info@synthonix.com
Country
United States
ProdList
6872
Advantage
58
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
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View Lastest Price from 2,4,6-trichloro-3-nitropyridine manufacturers

Career Henan Chemical Co
Product
2,4,6-trichloro-3-nitropyridine 60186-13-2
Price
US $1.00/KG
Min. Order
1g
Purity
99.0%
Supply Ability
100kg
Release date
2020-01-10

60186-13-2, 2,4,6-trichloro-3-nitropyridineRelated Search:

2-Chloro-3-nitropyridine 2,4-DICHLORO-5-NITROPYRIDINE 2,5-Dichloro-3-nitropyridine 2,4-Dichloro-3-nitropyridine 2-CHLORO-3,5-DINITROPYRIDINE

  • Pyridine, 2,4,6-trichloro-3-nitro-
  • 2,4,6-TRICHLORO-3-NITROPYRIDINE
  • 60186-13-2