ChemicalBook > CAS DataBase List > N-(3,5-DiMethyladaMantan-1-yl)forMaMide

N-(3,5-DiMethyladaMantan-1-yl)forMaMide

Product Name
N-(3,5-DiMethyladaMantan-1-yl)forMaMide
CAS No.
351329-88-9
Chemical Name
N-(3,5-DiMethyladaMantan-1-yl)forMaMide
Synonyms
N-ForMyl MeMantine;Memantine USP RC E;MeMantine Related CoMpound E; Adamantane Impurity E;Memantine USP impurity E;Memantine Related Compound 2;N-(3,5-DiMethyladaMantan-1-yl);Memantine USP Related Compound E;1-ForMylaMino-3,5-diMethyladaMantane;N-(3,5-dimethyl-1-adamantyl)formamide
CBNumber
CB32622883
Molecular Formula
C13H21NO
Formula Weight
207.31
MOL File
351329-88-9.mol
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N-(3,5-DiMethyladaMantan-1-yl)forMaMide Property

Melting point:
69.5℃
Boiling point:
325.6±9.0 °C(Predicted)
Density 
1.07±0.1 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
16.08±0.60(Predicted)
color 
White to Off-White
InChI
InChI=1S/C13H21NO/c1-11-3-10-4-12(2,6-11)8-13(5-10,7-11)14-9-15/h9-10H,3-8H2,1-2H3,(H,14,15)
InChIKey
NYQWYYMEIBHRSB-UHFFFAOYSA-N
SMILES
C(NC12CC3(C)CC(CC(C)(C3)C1)C2)=O
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Safety

HS Code 
2903890002
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
F700740
Product name
N-FormylMemantine
Packaging
50mg
Price
$100
Updated
2021/12/16
TRC
Product number
F700740
Product name
N-FormylMemantine
Packaging
100mg
Price
$125
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD57647
Product name
N-3,5-Dimethyladamantan-1-yl formamide
Packaging
50mg
Price
$170
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD57647
Product name
N-3,5-Dimethyladamantan-1-yl formamide
Packaging
100mg
Price
$210
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD57647
Product name
N-3,5-Dimethyladamantan-1-yl formamide
Packaging
250mg
Price
$250
Updated
2021/12/16
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N-(3,5-DiMethyladaMantan-1-yl)forMaMide Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

N-Formyl Memantine is an impurity of Memantine (M218000). Memantine impurity E per USP.

Synthesis

941-37-7

77287-34-4

351329-88-9

GENERAL METHOD: To a 17 mL stainless steel pressure microreactor or glass vial under argon protection, 0.3 mmol of manganese-containing catalyst, 10 mmol of 1-bromo-3,5-dimethyladamantane (I), and 30 mmol of formamide were sequentially added. The reaction mixture was heated with stirring at 120-130°C for 3-4 hours. After completion of the reaction, the reactor was cooled to room temperature and opened. The reaction mixture was washed with water and the reaction product was subsequently extracted with 33 mL of dichloromethane. The solvent was removed by distillation under reduced pressure and the residue was purified by recrystallization. Further purification by silica gel column chromatography (eluent: hexane-ethyl acetate mixed solvent) afforded N-(3,5-dimethyladamantan-1-yl)formamide (II). The yield of the product was 78% and the melting point was 69-70°C (hexane recrystallization). Its physicochemical properties and NMR spectral data were in agreement with those reported in the literature [7].

References

[1] Russian Journal of General Chemistry, 2015, vol. 85, # 7, p. 1771 - 1772
[2] Zh. Obshch. Khim., 2015, vol. 85, # 7, p. 1210 - 1211,2
[3] Patent: WO2010/15415, 2010, A1. Location in patent: Page/Page column 16-17
[4] Patent: WO2010/83996, 2010, A1. Location in patent: Page/Page column 20-21

N-(3,5-DiMethyladaMantan-1-yl)forMaMide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(3,5-DiMethyladaMantan-1-yl)forMaMide Suppliers

Canada 2 China 108 India 5 United Kingdom 2 United States 6 Global 123
Standardpharm Co. Ltd.
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86-714-3992388
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United States
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Cato Research Chemicals Inc.
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+86-020-81960175-877 4000-868-328
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tianwen.zhan@cato-chem.com
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United States
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View Lastest Price from N-(3,5-DiMethyladaMantan-1-yl)forMaMide manufacturers

Wuhan Boye Science And Technology Development Co., Ltd.
Product
N-(3,5-DiMethyladaMantan-1-yl)forMaMide 351329-88-9
Price
US $0.00/ASSAYS
Min. Order
100ASSAYS
Purity
98%
Supply Ability
1tons
Release date
2021-04-25
Career Henan Chemical Co
Product
N-(3,5-DiMethyladaMantan-1-yl)forMaMide 351329-88-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
100kg
Release date
2020-01-18

351329-88-9, N-(3,5-DiMethyladaMantan-1-yl)forMaMideRelated Search:

Memantine Related Compound 1 Memantine-glucose Adduct 1 1-Bromo-3,5-dimethyladamantane 3-AMINO-5,7-DIMETHYLADAMANTAN-1-OL Hydrochloride Memantine-Galactose Adduct 1 1-Actamido-3,5-dimethyladmantane Memantine Glucuronic Acid Conjugate (Furanose Form) 3,5-DiMethyl-1-nitroadaMantane Tricyclo[3.3.1.13,7]decan-1-aMine, 3,5,7-triMethyl-, hydrochloride Memantine Lactose Adduct Demethyl Memantine Hydrochloride Memantine

  • 1-ForMylaMino-3,5-diMethyladaMantane
  • N-(3,5-DiMethyladaMantan-1-yl)forMaMide
  • N-(3,5-DiMethyltricyclo[3.3.1.13,7]dec-1-yl)forMaMide
  • N-ForMyl MeMantine
  • Memantine USP Related Compound E
  • Memantine Related Compound E (15 mg) (N-3,5-Dimethyladamantan-1-yl formamide)
  • Memantine USP RC E
  • MeMantine Related CoMpound E
  • Memantine Impurity 5(Memantine USP RC E)
  • N-(3,5-dimethyl-1-adamantyl)formamide
  • N-(3,5-DiMethyladaMantan-1-yl)
  • FORMAMIDE, N-(3,5-DIMETHYLTRICYCLO[3.3.1.13,7]DEC-1-YL)-
  • N-((1r,3R,5S,7r)-3,5-dimethyladamantan-1-yl)formamide
  • Memantine Related Compund E (N-3,5-Dimethyladamantan-1-yl formamide)
  • Adamantane Impurity E
  • Memantine Impurity EQ: What is Memantine Impurity E Q: What is the CAS Number of Memantine Impurity E Q: What is the storage condition of Memantine Impurity E Q: What are the applications of Memantine Impurity E
  • Memantine Related Compound E (N-3,5-Dimethyladamantan-1-yl formamide) (1380557)
  • Memantine Related Compound 2
  • Piperidine,1-(3-chloropropyl)-,hydrochloride(1:3)
  • Memantine Related Compound E N-((1r,3R,5S,7r)-3,5-dimethyladamantan-1-yl)formamide
  • Memantine USP impurity E
  • N-(3,5-Dimethyladamantan-1-yl)formamide,98%
  • 351329-88-9
  • 351329-77-8
  • Amines
  • Impurities
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