Plazomicin
- Product Name
- Plazomicin
- CAS No.
- 1154757-24-0
- Chemical Name
- Plazomicin
- Synonyms
- ACHN 490;PlazoMicin;Plazomicin API;Sisomicin Impurity 10;IYDYFVUFSPQPPV-BPUQVFSTSA-N;Pirimicarb Impurity 9 (Ethirimol);O-2-AMino-2,3,4,6-tetradeoxy-6-[(2-hydroxyethyl)aMino]-α-D-glycero-hex-4-enopyranosyl-(1→4)-O-[3-deoxy-4-C-Methyl-3-(MethylaMino)-β-L-arabinopyranosyl-(1→6)]-N1-[(2S)-4-aMino-2-hydroxy-1-oxobutyl]-2-deoxy-D-streptaMine;D-Streptamine, O-2-amino-2,3,4,6-tetradeoxy-6-[(2-hydroxyethyl)amino]-α-D-glycero-hex-4-enopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)]-N1-[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-
- CBNumber
- CB32622979
- Molecular Formula
- C25H48N6O10
- Formula Weight
- 592.68282
- MOL File
- 1154757-24-0.mol
Plazomicin Property
- Melting point:
- >185°C (dec.)
- Boiling point:
- 896.4±65.0 °C(Predicted)
- Density
- 1.40±0.1 g/cm3(Predicted)
- storage temp.
- Hygroscopic, -20°C Freezer, Under inert atmosphere
- solubility
- Water (Slightly)
- form
- Solid
- pka
- 13.11±0.20(Predicted)
- color
- Pale Yellow
N-Bromosuccinimide Price
- Product number
- 48368
- Product name
- Plazomicin
- Packaging
- 25mg
- Price
- $13500
- Updated
- 2021/12/16
Plazomicin Chemical Properties,Usage,Production
Description
Plazomicin (PLZ) is a novel aminoglycoside approved by the U.S. Food and Drug Administration (FDA) for the treatment of complicated urinary tract infections (cUTI, including acute pyelonephritis) in adults due to multidrug-resistant carbapenem-resistant Enterobacterales (CRE) or extended-spectrum beta-lactamase (ESBL) producing bacteria. Despite the FDA Black Box Warning for aminoglycoside class effects, PLZ exhibited a favourable safety profile with decreased adverse effects in the largest in-human trials. In vitro, activity of PLZ, in comparison with that of other aminoglycosides, was found to be excellent, with 92.3% to 98.0% overall susceptibility in Enterobacterales, including CRE. Recently, PLZ was also shown to be active against certain multidrug-resistant (MDR) and extensively drug-resistant (XDR) Gram-negative pathogens for which limited treatment options are left[1-2].
Uses
Plazomicin (ACHN 490) is a potent aminoglycoside antibiotic in the fight against antimicrobial resistance. Plazomicin has in vitro activity against several multi-drug-resistant organisms, including carbapenem-resistant Enterobacteriaceae. Plazomicin has the potential to be used for multi-drug-resistant complicated urinary tract infections (cUTIs) or in combination for serious carbapenem-resistant Enterobacteriaceae infections[1].
References
[1] Kristy M Shaeer. “Plazomicin: A Next-Generation Aminoglycoside.” Pharmacotherapy 39 1 (2019): 77–93.
[2] Laurine S Blanchard. “Multicenter Clinical Evaluation of ETEST Plazomicin (PLZ) for Susceptibility Testing of Enterobacterales.” Journal of Clinical Microbiology 60 1 (2022): e0183121.
Plazomicin Preparation Products And Raw materials
Raw materials
Preparation Products
Plazomicin Suppliers
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- 021-50135380
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- China
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View Lastest Price from Plazomicin manufacturers
- Product
- ACHN 490 1154757-24-0
- Price
- US $0.00/kg
- Min. Order
- 20kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2024-10-29
- Product
- Plazomicin 1154757-24-0
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10
- Release date
- 2024-08-04