SRT2104 (GSK2245840)

Product Name: SRT2104 (GSK2245840)
CAS No.: 1093403-33-8
Chemical Name: SRT2104 (GSK2245840)
Synonyms: CS-2293;GSK2245840;sirtuin Modulator;SRT-2104;SRT 2104;SRT2104 (GSK2245840);SRT2104 (GSK2245840) USP/EP/BP;SRT 2104,Sirtuin,Inhibitor,SRT-2104,inhibit;(E)-3-(3-HYDROXY-4-METHOXYPHENYL)PROP-2-ENOIC ACID;4-methyl-N-(2-(3-(morpholinomethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)-2-(yridine-3-yl)thiazole-5-carboxamide;4-Methyl-N-[2-[3-(morpholinomethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-(pyridin-3-yl)thiazole-5-carboxamide
CBNumber: CB32624034
Molecular Formula: C26H24N6O2S2
Formula Weight: 516.64
MOL File: 1093403-33-8.mol

More

Less

SRT2104 (GSK2245840) Property

Density: 1.46±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in H2O; insoluble in EtOH; ≥6.46 mg/mL in DMSO with gentle warming
form: Powder
pka: 11.40±0.70(Predicted)

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 28380
Product name: SRT 2104
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 28380
Product name: SRT 2104
Packaging: 25mg
Price: $533
Updated: 2024/03/01

Cayman Chemical

Product number: 28380
Product name: SRT 2104
Packaging: 5mg
Price: $172
Updated: 2024/03/01

Cayman Chemical

Product number: 28380
Product name: SRT 2104
Packaging: 10mg
Price: $299
Updated: 2024/03/01

Biosynth Carbosynth

Product number: FM71744
Product name: SRT2104
Packaging: 25mg
Price: $325
Updated: 2021/12/16

More

Less

SRT2104 (GSK2245840) Chemical Properties,Usage,Production

Biological Activity

srt2104 (gsk2245840) is a selective sirt1 activator involved in the regulation of energy homeostasis. sirt1, also known as nad-dependent deacetylase sirtuin-1, is a member of the sirtuin family of proteins.

in vitro

in c2c12 myoblasts stably transfected with small hairpin rna to knock-down sirt1, srt2104 increased ap activity, a marker for osteogenic differentiation. this effect was totally dependent on sirt1 expression [1].

in vivo

in male c57bl/6j mice, administration of srt2104 (100 mg/kg, p.o.) extended both mean and maximal lifespan of mice fed a standard diet, and enhanced bone mineral density, motor coordination, and insulin sensitivity and decreased inflammation. short-term srt2104 administration preserved bone and muscle mass in an experimental model of atrophy [1]. in male n171-82q hd mice with huntington's disease, srt2104 (diet containing 0.5% srt2104) effectively penetrated the blood-brain barrier, attenuated brain atrophy, improved motor function, and extended survival [2].

References

[1]. mercken e m, mitchell s j, martin‐montalvo a, et al. srt2104 extends survival of male mice on a standard diet and preserves bone and muscle mass[j]. aging cell, 2014, 13(5): 787-796.
[2]. jiang m, zheng j, peng q, et al. sirtuin 1 activator srt2104 protects huntington's disease mice[j]. annals of clinical and translational neurology, 2014, 1(12): 1047-1052.

SRT2104 (GSK2245840) Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

SRT2104 (GSK2245840) Suppliers

China 70 India 1 United States 11 Global 82

Shanghai Qianhe Biological Technology Co., Ltd.

Tel: 021-58337595 13621714589
Fax: 021-58337595
Email: 93732879@qq.com
Country: China
ProdList: 225
Advantage: 58

Dezhou LonWel Pharmaceutical Technology Co., Ltd.

Tel: 13761310616
Fax: QQ: 39324283
Email: 39324283@qq.com
Country: China
ProdList: 1946
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2923
Advantage: 55

Chembest Research Laboratories Limited

Tel: 021-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6011
Advantage: 61

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4654
Advantage: 58

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7553
Advantage: 61

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4863
Advantage: 58

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4153
Advantage: 55

YouCoChem (Beijing) Chemical Technology Co., Ltd.

Tel: 18800159827
Email: youcochem@163.com
Country: China
ProdList: 161
Advantage: 50

1093403-33-8, SRT2104 (GSK2245840)Related Search:

SRT3025 SRT1720 N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide 5-Aza-2'-deoxycytidine 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE Dasatinib Dabrafenib PF-04691502 Sunitinib Malate

SRT2104 (GSK2245840)

(E)-3-(3-HYDROXY-4-METHOXYPHENYL)PROP-2-ENOIC ACID

GSK2245840

5-ThiazolecarboxaMide, 4-Methyl-N-[2-[3-(4-MorpholinylMethyl)iMidazo[2,1-b]thiazol-6-yl]phenyl]-2-(3-pyridinyl)-

sirtuin Modulator

4-Methyl-N-[2-[3-(morpholinomethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-(pyridin-3-yl)thiazole-5-carboxamide

CS-2293

SRT-2104;SRT 2104

4-methyl-N-(2-(3-(morpholinomethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)-2-(yridine-3-yl)thiazole-5-carboxamide

4-methyl-N-[2-[3-(morpholin-4-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]-2-pyridin-3-yl-1,3-thiazole-5-carboxamide

SRT2104 (GSK2245840) USP/EP/BP

SRT 2104,Sirtuin,Inhibitor,SRT-2104,inhibit

1093403-33-8

Inhibitors