BMS-265246

Product Name: BMS-265246
CAS No.: 582315-72-8
Chemical Name: BMS-265246
Synonyms: CS-984;BMS-265246;BMS-265246, >=98%;BMS-265246 USP/EP/BP;BMS265246; BMS 265246;(4-Butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)-methanone;Methanone, (4-butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)-;(4-Butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)-methanone BMS265246
CBNumber: CB32624100
Molecular Formula: C18H17F2N3O2
Formula Weight: 345.34
MOL File: 582315-72-8.mol

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BMS-265246 Property

Boiling point:: 552.9±50.0 °C(Predicted)
Density: 1.304±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in H2O; insoluble in EtOH; ≥17.25 mg/mL in DMSO
form: solid
pka: 8.50±0.40(Predicted)
color: White to pink

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19168
Product name: BMS-265246
Purity: ≥95%
Packaging: 1mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 19168
Product name: BMS-265246
Purity: ≥95%
Packaging: 5mg
Price: $270
Updated: 2024/03/01

Tocris

Product number: 5654
Product name: BMS265246
Purity: ≥97%(HPLC)
Packaging: 10
Price: $189
Updated: 2021/12/16

Tocris

Product number: 5654
Product name: BMS265246
Purity: ≥97%(HPLC)
Packaging: 50
Price: $794
Updated: 2021/12/16

Usbiological

Product number: 004336
Product name: BMS-265246
Packaging: 5mg
Price: $566
Updated: 2021/12/16

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BMS-265246 Chemical Properties,Usage,Production

Uses

BMS-265246 is a potent and selective pyra-zolopyridine based inhibitor of cdk2/cyclinE, cdk1/cyclinB and cdk4/ cyclinD.

Biological Activity

bms265246 is a potent and selective inhibitor for cdk1 and cdk2 (ic50= 6 nm and 9 nm)cyclin-dependent kinases (cdk) are a group of serine/threonine kinases. they are activated by coupling to cyclin and participate in the regulation of cell cycle.bms265246 inhibited the cdk4/cycd activity and prevented a2780 cytox (ic50 = 0.23 μm and 0.76 μm) [1]. in hct-116 cells, bms-265246 blocked the cell proliferation (ec50= 0.293 μm—0.492 μm). following the treatment of bms-265246, low dna intensity, large round nuclei and 4n dna content were observed in the dominant cell population –g2 arrested cells. [2]

storage

Store at -20°C

References

1. misra rn, xiao hy, rawlins db et al. 1h-pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases: highly potent 2,6-difluorophenacyl analogues. bioorgmed chem lett. 2003 jul 21;13(14):2405-8.2. sutherland jj, low j, blosser w et al. a robust high-content imaging approach for probing the mechanism of action and phenotypic outcomes of cell-cycle modulators. mol cancer ther. 2011 feb;10(2):242-54.

BMS-265246 Preparation Products And Raw materials

Raw materials

Preparation Products

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BMS-265246 Suppliers

Canada 1 China 69 India 1 United Kingdom 2 United States 16 Global 89

AdooQ Bioscience CHINA

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BMS-265246

BMS-265246, >=98%

(4-Butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)-methanone

(4-Butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)-methanone BMS265246

BMS265246; BMS 265246

CS-984

Methanone, (4-butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)-

BMS-265246 USP/EP/BP

582315-72-8

Inhibitors