BMS-265246

Product Name: BMS-265246
CAS No.: 582315-72-8
Chemical Name: BMS-265246
Synonyms: CS-984;BMS-265246;BMS-265246, >=98%;BMS-265246 USP/EP/BP;BMS265246; BMS 265246;(4-Butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)-methanone;Methanone, (4-butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)-;(4-Butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)-methanone BMS265246
CBNumber: CB32624100
Molecular Formula: C18H17F2N3O2
Formula Weight: 345.34
MOL File: 582315-72-8.mol

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BMS-265246 Property

Boiling point:: 552.9±50.0 °C(Predicted)
Density: 1.304±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in H2O; insoluble in EtOH; ≥17.25 mg/mL in DMSO
form: solid
pka: 8.50±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19168
Product name: BMS-265246
Purity: ≥95%
Packaging: 1mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 19168
Product name: BMS-265246
Purity: ≥95%
Packaging: 5mg
Price: $270
Updated: 2024/03/01

Tocris

Product number: 5654
Product name: BMS265246
Purity: ≥97%(HPLC)
Packaging: 10
Price: $189
Updated: 2021/12/16

Tocris

Product number: 5654
Product name: BMS265246
Purity: ≥97%(HPLC)
Packaging: 50
Price: $794
Updated: 2021/12/16

Usbiological

Product number: 004336
Product name: BMS-265246
Packaging: 5mg
Price: $566
Updated: 2021/12/16

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BMS-265246 Chemical Properties,Usage,Production

Uses

BMS-265246 is a potent and selective pyra-zolopyridine based inhibitor of cdk2/cyclinE, cdk1/cyclinB and cdk4/ cyclinD.

Biological Activity

bms265246 is a potent and selective inhibitor for cdk1 and cdk2 (ic50= 6 nm and 9 nm)cyclin-dependent kinases (cdk) are a group of serine/threonine kinases. they are activated by coupling to cyclin and participate in the regulation of cell cycle.bms265246 inhibited the cdk4/cycd activity and prevented a2780 cytox (ic50 = 0.23 μm and 0.76 μm) [1]. in hct-116 cells, bms-265246 blocked the cell proliferation (ec50= 0.293 μm—0.492 μm). following the treatment of bms-265246, low dna intensity, large round nuclei and 4n dna content were observed in the dominant cell population –g2 arrested cells. [2]

storage

Store at -20°C

References

1. misra rn, xiao hy, rawlins db et al. 1h-pyrazolo[3,4-b]pyridine inhibitors of cyclin-dependent kinases: highly potent 2,6-difluorophenacyl analogues. bioorgmed chem lett. 2003 jul 21;13(14):2405-8.2. sutherland jj, low j, blosser w et al. a robust high-content imaging approach for probing the mechanism of action and phenotypic outcomes of cell-cycle modulators. mol cancer ther. 2011 feb;10(2):242-54.

BMS-265246 Preparation Products And Raw materials

Raw materials

Preparation Products

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BMS-265246 Suppliers

Canada 1 China 67 India 1 United Kingdom 2 United States 16 Global 87

AdooQ Bioscience CHINA

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BMS-265246

BMS-265246, >=98%

(4-Butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)-methanone

(4-Butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)-methanone BMS265246

BMS265246; BMS 265246

CS-984

Methanone, (4-butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)-

BMS-265246 USP/EP/BP

582315-72-8

Inhibitors