ChemicalBook > CAS DataBase List > Glucocorticoid receptor agonist

Glucocorticoid receptor agonist

Product Name
Glucocorticoid receptor agonist
CAS No.
1245526-82-2
Chemical Name
Glucocorticoid receptor agonist
Synonyms
Glucocorticoid receptor agonist;1H-Pyrrolo[2,3-c]pyridine-2-ethanol, α-[2-(5-fluoro-2-hydroxyphenyl)-2-Methylpropyl]-α-(trifluoroMethyl)-, (αR)-;alpha-[2-(5-Fluoro-2-hydroxyphenyl)-2-methylpropyl]-alpha-(trifluoromethyl)-(alphaR)-1H-pyrrolo[2,3-c]pyridine-2-ethanol;(ALPHAR)-ALPHA-[2-(5-FLUORO-2-HYDROXYPHENYL)-2-METHYLPROPYL]-ALPHA-(TRIFLUOROMETHYL)-1H-PYRROLO[2,3-C]PYRIDINE-2-ETHANOL
CBNumber
CB32624175
Molecular Formula
C20H20F4N2O2
Formula Weight
396.38
MOL File
1245526-82-2.mol
More
Less

Glucocorticoid receptor agonist Property

Boiling point:
563.1±50.0 °C(Predicted)
Density 
1.373
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
pka
10.16±0.43(Predicted)
form 
Powder
color 
White to yellow
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

ChemScene
Product number
CS-0520
Product name
Glucocorticoidreceptoragonist
Purity
99.56%
Packaging
5mg
Price
$383
Updated
2021/12/16
ApexBio Technology
Product number
A3438
Product name
Glucocorticoidreceptoragonist
Packaging
5mg
Price
$467
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CCH0012915
Product name
(ALPHAR)-ALPHA-[2-(5-FLUORO-2-HYDROXYPHENYL)-2-METHYLPROPYL]-ALPHA-(TRIFLUOROMETHYL)-1H-PYRROLO-[2,3-C]PYRIDINE-2-ETHANOL
Purity
95.00%
Packaging
5MG
Price
$611.6
Updated
2021/12/16
ChemScene
Product number
CS-0520
Product name
Glucocorticoidreceptoragonist
Purity
99.56%
Packaging
10mg
Price
$726
Updated
2021/12/16
ApexBio Technology
Product number
A3438
Product name
Glucocorticoidreceptoragonist
Packaging
10mg
Price
$886
Updated
2021/12/16
More
Less

Glucocorticoid receptor agonist Chemical Properties,Usage,Production

Uses

Glucocorticoid receptor agonist is a Glucocorticoid receptor agonist that acts on Glucocorticoid receptor (GR), progesterone receptor (PR) and mineralocorticoid receptor (MR) with the IC50 values of 2.1 , 1200 and 210 nM, respectively. Glucocorticoid receptor agonist has steroid-like anti-inflammatory properties and may be used to improve metabolism and reduce increased levels of body fat and serum insulin[1].

in vivo

Glucocorticoid receptor agonist ((R)-16) exhibits good pharmacokinetic properties in Sprague-Dawley rats[1].
Glucocorticoid receptor agonist ((R)-16) (30 and 10 mg/kg, p.o., daily, 5 weeks) can reduce the increased levels of body fat and serum insulin and shows an effective inhibition of TNF-α production in LPS-stimulated mouse model[1].
The pharmacokinetic parameters of Glucocorticoid receptor agonist ((R)-16) in Sprague-Dawley rat (5 mg/kg i.v. or 30 mg/kg p.o.)[1].

ParametersCl (i.v.)(mL/min/kg)VSS(iv) (L/kg)T1/2(iv)(h)Cmax(po) (ng/mL)AUCinf(po) (h·ng/mL)F(po)%
(R)-16497.61.85509487948

References

[1] Doris Riether, et al. Nonsteroidal dissociated glucocorticoid agonists containing azaindoles as steroid A-ring mimetics. J Med Chem. 2010 Sep 23;53(18):6681-98. DOI:10.1021/jm100751q

Glucocorticoid receptor agonist Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Glucocorticoid receptor agonist Suppliers

China 19 United States 10 Global 29
Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6003
Advantage
61
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
LETOPHARM LIMITED
Tel
+86-21-5821 5861
Fax
+86-21-5106 2861
Email
sales@letopharm.com
Country
China
ProdList
2384
Advantage
58
Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Fax
020-61288700
Email
505721671@qq.com
Country
China
ProdList
3866
Advantage
58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Absin Bioscience Inc.
Tel
021-38015121 18438616290
Email
lanwu@univ-bio.com
Country
China
ProdList
24731
Advantage
58
Shanghai hongqu biomedical technology co. LTD
Tel
88888888888
Email
hongquchem@qq.com
Country
China
ProdList
5132
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
Nantong QuanYi Biotechnology Co., Ltd
Tel
0513-66337626 18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
5929
Advantage
58
Adooq Bioscience LLC
Tel
400-025-6535
Email
sales@adooq.cn
Country
China
ProdList
6215
Advantage
58
Guangzhou Tangzhuang Biotechnology Co., Ltd.
Tel
13432694097
Country
CHINA
ProdList
158
Advantage
58
Guangzhou Yiran Biotechnology Co., Ltd.
Tel
15571990006
Country
CHINA
ProdList
141
Advantage
58
Guangzhou Haotian Biotechnology Co., Ltd.
Tel
15571990006
Country
CHINA
ProdList
122
Advantage
58
Biorbyt Ltd.
Tel
--
Fax
--
Email
info@biorbyt.com
Country
CHINA
ProdList
6482
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58
Shanghai Weiwei Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
sales@wheybio.com
Country
CHINA
ProdList
4398
Advantage
58
Shanghai Yijie Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
SHYIJIEBIO@126.COM
Country
CHINA
ProdList
3510
Advantage
58
Shanghai Machine Pure Industrial Co., Ltd.
Tel
--
Fax
--
Email
3245176082@qq.com
Country
CHINA
ProdList
6800
Advantage
58

1245526-82-2, Glucocorticoid receptor agonistRelated Search:

2'-Hydroxyacetophenone Dihydrocaffeic acid Dihydroxybenzoic acid Loteprednol Loteprednol etabonate GR (Glucocorticoid receptor)

  • 1H-Pyrrolo[2,3-c]pyridine-2-ethanol, α-[2-(5-fluoro-2-hydroxyphenyl)-2-Methylpropyl]-α-(trifluoroMethyl)-, (αR)-
  • (ALPHAR)-ALPHA-[2-(5-FLUORO-2-HYDROXYPHENYL)-2-METHYLPROPYL]-ALPHA-(TRIFLUOROMETHYL)-1H-PYRROLO[2,3-C]PYRIDINE-2-ETHANOL
  • Glucocorticoid receptor agonist
  • alpha-[2-(5-Fluoro-2-hydroxyphenyl)-2-methylpropyl]-alpha-(trifluoromethyl)-(alphaR)-1H-pyrrolo[2,3-c]pyridine-2-ethanol
  • 1245526-82-2