SMND-309
- Product Name
- SMND-309
- CAS No.
- 1065559-56-9
- Chemical Name
- SMND-309
- Synonyms
- SMND-309;SMND 309;SMND309;(2E)-2-[6-[(E)-2-Carboxyvinyl]-2,3-dihydroxyphenyl]-3-(3,4-dihydroxyphenyl)acrylic acid;Benzeneacetic acid, 6-[(1E)-2-carboxyethenyl]-α-[(3,4-dihydroxyphenyl)methylene]-2,3-dihydroxy-, (αE)-
- CBNumber
- CB32624296
- Molecular Formula
- C18H14O8
- Formula Weight
- 358.3
- MOL File
- 1065559-56-9.mol
SMND-309 Property
- Melting point:
- >400℃
- Boiling point:
- 667.1±55.0 °C(Predicted)
- Density
- 1.655
- storage temp.
- Store at -20°C
- solubility
- DMSO: ≥ 3.7 mg/mL (10.33 mM)
- pka
- 3.20±0.10(Predicted)
- form
- Solid
- color
- Light yellow to yellow
N-Bromosuccinimide Price
- Product number
- API0014146
- Product name
- SMND-309
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $421.3
- Updated
- 2021/12/16
- Product number
- DC9531
- Product name
- SMND-309
- Purity
- >98%
- Packaging
- 100mg
- Price
- $1050
- Updated
- 2021/12/16
- Product number
- DC9531
- Product name
- SMND-309
- Purity
- >98%
- Packaging
- 1g
- Price
- $4200
- Updated
- 2021/12/16
- Product number
- CD31004664
- Product name
- SMND-309
- Purity
- 98+%
- Packaging
- 5mg
- Price
- $129
- Updated
- 2021/12/16
- Product number
- CD31004664
- Product name
- SMND-309
- Purity
- 98+%
- Packaging
- 10mg
- Price
- $229
- Updated
- 2021/12/16
SMND-309 Chemical Properties,Usage,Production
Uses
SMND-309 is a metabolite of salvianolic acid B, and exhibits neuroprotective effects in cultured neurons and in permanent middle cerebral artery occlusion rats[1][2].
in vivo
SMND-309 (2.5-10 mg/kg; oral intragastric; once a day; for 4 weeks; male Sprague-Dawley rats) treatment ameliorates liver function and decreases the elevation of serum hyaluronic acid, laminin, procollagen type III levels and hydroxyproline content in liver tissue. SMND-309 also decreases the elevation in the malondialdehyde level and restored the decrease in superoxide dismutase and glutathione peroxidase activities. SMND-309 treatment reduces the liver damage and the liver fibrosis grade. SMND-309 treatment powerfully down-regulated the expression of connective tissue growth factor (CTGF) in serum and liver[1].
| Animal Model: | Male Sprague-Dawley rats (180-200 g) with carbon tetrachloride[1] |
| Dosage: | 2.5 mg/kg, 5 mg/kg and 10 mg/kg |
| Administration: | Oral intragastric; once a day; for 4 weeks |
| Result: | The antifibrotic mechanisms might be associated with its ability to suppress the expression of CTGF as well as scavenge lipid peroxidation products and increase endogenous antioxidant enzyme activity. |
References
[1] Hou J, Tian J, Jiang W, Gao Y, Fu F.
Therapeutic effects of SMND-309, a new metabolite of salvianolic acid B, on experimental liver fibrosis.
Eur J Pharmacol. 2011 Jan 10;650(1):390-5. DOI:10.1016/j.ejphar.2010.10.019
[2] Yang J, Zhang G, Tian J, Li C, Jiang W, Xing Y, Zhu H, Hou J, Xu H, Wu J.
Cardioprotective effect of SMND-309, a novel derivate of salvianolic acid B on acute myocardial infarction in rats.
Basic Clin Pharmacol Toxicol. 2010 Apr;106(4):317-23. DOI:10.1111/j.1742-7843.2009.00490.x
[3] Wang Y, Zhang J, Han M, et al. SMND-309 promotes neuron survival through the activation of the PI3K/Akt/CREB-signalling pathway. Pharm Biol. 2016;54(10):1982-1990. DOI:10.3109/13880209.2015.1137951
SMND-309 Preparation Products And Raw materials
Raw materials
Preparation Products
SMND-309 Suppliers
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