ChemicalBook > CAS DataBase List > AMG 487

AMG 487

Product Name
AMG 487
CAS No.
473719-41-4
Chemical Name
AMG 487
Synonyms
AMG 487;AMG 487 - Bio-X ?;AMG 487, 10 mM in DMSO;N-[(1R)-1-[3-(4-ethoxyphenyl)-4-oxoquinazolin-2-yl]ethyl]-N-(pyridin-2-ylmethyl)-2-[4-(trifluoromethoxy)phenyl]acetamide - [AC79904];N-[(1R)-1-[3-(4-Ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-N-(3-pyridinylmethyl)-4-(trifluoromethoxy)benzeneacetamide;(R)-N-(1-(3-(4-Ethoxyphenyl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)ethyl)-N-(pyridin-3-ylmethyl)-2-(4-(trifluoromethoxy)phenyl)acetamide;Benzeneacetamide, N-[(1R)-1-[3-(4-ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-N-(3-pyridinylmethyl)-4-(trifluoromethoxy)-;Metastatic,metastasis,inhibit,cancer,CXCL11,CXC chemokine receptors,AMG-487,AMG487,CXCL10,chemokine,receptor,CXCR3,AMG 487,CXCR,Inhibitor,Breast,colon
CBNumber
CB32627318
Molecular Formula
C32H28F3N5O4
Formula Weight
603.59
MOL File
473719-41-4.mol
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AMG 487 Property

Melting point:
161.2℃ (ethyl acetate heptane )
storage temp. 
Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO:41.0(Max Conc. mg/mL);67.93(Max Conc. mM)
form 
A crystalline solid
color 
White to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3153
Product name
AMG 487
Purity
≥98% (HPLC)
Packaging
10MG
Price
$98.1
Updated
2026/03/19
Sigma-Aldrich
Product number
SML3153
Product name
AMG 487
Purity
≥98% (HPLC)
Packaging
50MG
Price
$394
Updated
2026/03/19
Cayman Chemical
Product number
28416
Product name
AMG 487
Packaging
1mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
28416
Product name
AMG 487
Packaging
25mg
Price
$684
Updated
2024/03/01
Cayman Chemical
Product number
28416
Product name
AMG 487
Packaging
5mg
Price
$179
Updated
2024/03/01
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AMG 487 Chemical Properties,Usage,Production

Uses

N-[(1R)-1-[3-(4-Ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-N-(3-pyridinylmethyl)-4-(trifluoromethoxy)benzeneacetamide is a selective and potent antagonist of the chemokine receptor CXCR3.

Biological Activity

AMG 487 is an orally available, potent and selective chemokine (C-X-C motif) receptor 3 (CXCR3) antagonist (IC50 = 8/8.2 nM against CXCL10/11 (IP-10/ITAC) for CXCR3 binding) th at inhibits CXCR3 ligands-induced cell migration (CXCL10/11/9 IC50 = 8/15/36 nM). AMG 487 inhibits ITAC-induced calcium mobilization in vitro (IC50 = 5 nM) and reduces bleomycin-induced cellular lung recruitment in wild-type mice to the same level as in Cxcr3-deficient mice in vivo (3 mg/kg b.i.d. s.c.).

in vivo

AMG 487 (0.03-10 mg/kg, s.c.) exhibits significant reduction in cellular infiltration into the lungs in a dose dependent manner[1].
AMG487 (5 mg/kg, s.c., twice daily) develops fewer metastases than that in vehicle-treated mice[2].
AMG487 (5 mg/kg, s.c.)-treated mice exhibits fewer pulmonary nodules than the control mice in both the models. AMG487 reduces the tumour volume[3].

IC 50

125I-IP10-CXCR3: 8 nM (IC50); 125I-ITAC-CXCR3: 8.2 nM (IC50)

AMG 487 Preparation Products And Raw materials

Raw materials

Preparation Products

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AMG 487 Suppliers

China 80 United Kingdom 1 United States 10 Global 91
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
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United States
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12952
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Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
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61
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
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58
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4769
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ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3505
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58
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
15781
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55
SPIRO PHARMA
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Fax
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Email
eric_feng1954@126.com
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China
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9248
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Taizhou Jinghao Chemical Co., Ltd.
Tel
86-576-88550069 13486888296
Fax
+86 (576) 8855-7772
Email
sales@jinghaochem.com
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China
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37
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Guangzhou QiYun Biotechnology Co., Ltd.
Tel
020-61288194 61288195
Fax
020-61288700
Email
505721671@qq.com
Country
China
ProdList
3866
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58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
89689
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60

473719-41-4, AMG 487Related Search:


  • AMG 487
  • N-[(1R)-1-[3-(4-Ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-N-(3-pyridinylmethyl)-4-(trifluoromethoxy)benzeneacetamide
  • Benzeneacetamide, N-[(1R)-1-[3-(4-ethoxyphenyl)-3,4-dihydro-4-oxopyrido[2,3-d]pyrimidin-2-yl]ethyl]-N-(3-pyridinylmethyl)-4-(trifluoromethoxy)-
  • (R)-N-(1-(3-(4-Ethoxyphenyl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)ethyl)-N-(pyridin-3-ylmethyl)-2-(4-(trifluoromethoxy)phenyl)acetamide
  • Metastatic,metastasis,inhibit,cancer,CXCL11,CXC chemokine receptors,AMG-487,AMG487,CXCL10,chemokine,receptor,CXCR3,AMG 487,CXCR,Inhibitor,Breast,colon
  • AMG 487, 10 mM in DMSO
  • AMG 487 - Bio-X ?
  • N-[(1R)-1-[3-(4-ethoxyphenyl)-4-oxoquinazolin-2-yl]ethyl]-N-(pyridin-2-ylmethyl)-2-[4-(trifluoromethoxy)phenyl]acetamide - [AC79904]
  • 473719-41-4
  • C32H28F3N5O4