ChemicalBook > CAS DataBase List > RI-1

RI-1

Product Name
RI-1
CAS No.
415713-60-9
Chemical Name
RI-1
Synonyms
RI-1;CS-909;RI1;RI-1;RI-1, >=98%;RAD51 inhibitor;RAD51 inhibitor 1;RI-1 >=98% (HPLC);RAD51 inhibitor RI-1;recombination,RI 1,homologous,Inhibitor,RAD51,RI-1,inhibit;3-Chloro-1-(3,4-dichlorophenyl)-4-Morpholino-1H-pyrrole-2,5-dione
CBNumber
CB32628355
Molecular Formula
C14H11Cl3N2O3
Formula Weight
361.61
MOL File
415713-60-9.mol
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RI-1 Property

Boiling point:
483.0±45.0 °C(Predicted)
Density 
1.61
storage temp. 
2-8°C
solubility 
DMSO: soluble10mg/mL, clear
pka
-3.45±0.20(Predicted)
form 
powder
color 
yellow to orange
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1274
Product name
RI-1
Purity
≥98% (HPLC)
Packaging
5mg
Price
$118
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1274
Product name
RI-1
Purity
≥98% (HPLC)
Packaging
25mg
Price
$462
Updated
2024/03/01
Cayman Chemical
Product number
24182
Product name
RI-1
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
24182
Product name
RI-1
Purity
≥98%
Packaging
5mg
Price
$70
Updated
2024/03/01
Cayman Chemical
Product number
24182
Product name
RI-1
Purity
≥98%
Packaging
10mg
Price
$122
Updated
2024/03/01
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RI-1 Chemical Properties,Usage,Production

Description

RI-1 (415713-60-9) is a potent and selective inhibitor of RAD51 (IC50 = 5-30 μM), a highly conserved protein that catalyzes DNA repair via homologous recombination.1 It specifically reduces gene conversion in human cells and stimulates single strand annealing. It covalently binds to Cys319 on the surface of RAD51 and disrupts protein-protein interaction. It potentiates the effect of DNA-damaging agents on tumor cells and is a novel tool for studying DNA repair in cells.2 Potentiates the killing of glioblastoma cells by ionizing radiation3 and alkylating drugs4.

Uses

RI 1 is a chemical inhibitor of RAD51, which disrupts homologous recombination in human cells.

Biochem/physiol Actions

RI-1 is a cell-permeable RAD51 inhibitor that binds covalently to the protein surface at Cysteine 319. RI-1 disrupts homologous recombination in human cells.

target

RAD51

References

1) Anand et al. (2017), Rad51-mediated double-strand break repair and mismatch correction of divergent substrates; Nature, 544 377 2) Budke et al. (2012), RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells; Nucleic Acids Res., 40 7347 3) Balbous et al. (2016), A radiosensitizing effect of RAD51 inhibition in glioblastoma stem-like cells; BMC Cancer, 16 604 4) Berte et al. (2016), Targeting Homologous Recombination by Pharmacological Inhibitors Enhances the Killing response of Glioblastoma Cells Treated with Alkylating Drugs; Mol. Cancer Ther., 15 2665

RI-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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RI-1 Suppliers

China 80 India 1 United Kingdom 1 United States 17 Global 99
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View Lastest Price from RI-1 manufacturers

Career Henan Chemical Co
Product
3-chloro-1-(3,4-dichlorophenyl)-4-morpholin-4-ylpyrrole-2,5-dione 415713-60-9
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2019-12-23

415713-60-9, RI-1Related Search:

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  • RI-1
  • 3-Chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-1H-pyrrole-2,5-dione
  • RI-1, >=98%
  • RAD51 inhibitor RI-1
  • RAD51 inhibitor 1
  • 3-Chloro-1-(3,4-dichlorophenyl)-4-Morpholino-1H-pyrrole-2,5-dione
  • 1H-Pyrrole-2,5-dione, 3-chloro-1-(3,4-dichlorophenyl)-4-(4-morpholinyl)-
  • RI1;RI-1
  • 3-chloro-1-(3,4-dichlorophenyl)-4-morpholin-4-ylpyrrole-2,5-dione
  • CS-909
  • 3-chloro-1-(3,4-dichlorophenyl)-4-(morpholin-4-yl)-2,5-dihydro-1H-pyrrole-2,5-dione
  • RAD51 inhibitor
  • RI-1 >=98% (HPLC)
  • recombination,RI 1,homologous,Inhibitor,RAD51,RI-1,inhibit
  • 415713-60-9
  • Inhibitors