ChemicalBook > CAS DataBase List > Vorapaxar

Vorapaxar

Product Name
Vorapaxar
CAS No.
618385-01-6
Chemical Name
Vorapaxar
Synonyms
MK-5348;[(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(1E)-2-[5-(3-Fluorophenyl)-2-pyridinyl]ethenyl]dodecahydro-1-methyl-3-oxonaphtho[2,3-c]furan-6-yl]-carbamic acid ethyl ester;CS-2015;CS-1663;Vorapaxar;Voarapaxar;7-Dihydrocapsaicin;Vorapaxar free base;Vorapaxar (MK-5348);Vorapaxar (SCH 530348)
CBNumber
CB32628522
Molecular Formula
C29H33FN2O4
Formula Weight
492.58
MOL File
618385-01-6.mol
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Vorapaxar Property

Boiling point:
676.0±55.0 °C(Predicted)
Density 
1.24±0.1 g/cm3(Predicted)
storage temp. 
Store at -20° C
solubility 
≥24.65 mg/mL in DMSO; insoluble in H2O; ≥10.64 mg/mL in EtOH with ultrasonic
form 
solid
pka
12.49±0.60(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H371May cause damage to organs

H373May cause damage to organs through prolonged or repeated exposure

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P309+P311IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.

P314Get medical advice/attention if you feel unwell.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
23119
Product name
Vorapaxar
Purity
≥98%
Packaging
1mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
23119
Product name
Vorapaxar
Purity
≥98%
Packaging
5mg
Price
$208
Updated
2024/03/01
ApexBio Technology
Product number
A8809
Product name
Vorapaxar
Packaging
10mg
Price
$252
Updated
2021/12/16
ChemScene
Product number
CS-5527
Product name
Vorapaxar
Purity
99.85%
Packaging
10mg
Price
$288
Updated
2021/12/16
AK Scientific
Product number
J96880
Product name
Vorapaxar
Packaging
10mg
Price
$288
Updated
2021/12/16
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Vorapaxar Chemical Properties,Usage,Production

Description

Vorapaxar is an orally bioavailable competitive antagonist of the proteinase-activated receptor (PAR1; Ki = 8.1 nM), also known as the thrombin receptor. It is selective for PAR1 over other PARs, as well as a number of GPCRs, ion channels, and receptors. It inhibits platelet aggregation induced by thrombin and haTRAP (IC50s = 47 and 25 nM, respectively). Vorapaxar (0.1 mg/kg, i.v.) completely inhibits platelet aggregation in cynomolgus monkeys ex vivo. Formulations containing vorapaxar are used in the prevention of thrombotic cardiovascular events.

Definition

ChEBI: A carbamate ester that is the ethyl ester of [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-{(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethyny }-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl]carbamic acid. A protease-activated receptor-1 antagonist used (as its sulfate salt) for the reduction of thrombotic cardiovascular events in patients with a history of myocardial infarction MI) or with peripheral arterial disease. It has been shown to reduce the rate of a combined endpoint of cardiovascular death, MI, stroke and urgent coronary revascularisation.

References

[1]. chackalamannil s & xia, y. thrombin receptor (par-1) antagonists as novel antithrombotic agents. expert opinion on therapeutic patents, 2006.16:493-505.
[2]. chackalamannil s, wang y, greenlee w j et al. 2008. discovery of a novel, orally active himbacine-based thrombin receptor antagonist (sch 530348) with potent antiplatelet activity. j med chem, 2008,51: 3061-3064.

Vorapaxar Preparation Products And Raw materials

Raw materials

Preparation Products

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Vorapaxar Suppliers

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View Lastest Price from Vorapaxar manufacturers

Hangzhou Huarong Pharm Co., Ltd.
Product
Vorapaxar 618385-01-6
Price
US $0.00-0.00/KG
Min. Order
1g
Purity
99%
Supply Ability
500KG
Release date
2021-09-16
Career Henan Chemical Co
Product
Vorapaxar 618385-01-6
Price
US $1.00/KG
Min. Order
1G
Purity
98%
Supply Ability
100KG
Release date
2018-08-21

618385-01-6, VorapaxarRelated Search:

vorapaxar sulfate M-9 GS9857 Voreloxin PVM/MA Panipenem Pazopanib LCZ696 RANAKININ Cilostazol (3R,3aS,4S,4aS,7R,9aR)-3-Methyl-7-nitro-1-oxo-N,N-diphenyl-1,3,3a,4,4a,5,6,7,8,9a-decahydronaphtho[2,3-c]furan-4-carboxamide Vorapaxar Sulfate Vorapaxar (1R,3aR,4aR,8aR,9S,9aR)-1-methyl-3-oxodecahydro-3H-spiro[naphtho[2,3-c]furan-6,2'-[1,3]dioxolane]-9-carboxylic acid

  • Vorapaxar
  • Vorapaxar (SCH 530348)
  • [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(1E)-2-[5-(3-Fluorophenyl)-2-pyridinyl]ethenyl]dodecahydro-1-methyl-3-oxonaphtho[2,3-c]furan-6-yl]-carbamic acid ethyl ester
  • Voarapaxar
  • Ethyl [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-{(E)-2-[5-(3-fluorophenyl)-2-pyridinyl]vinyl}-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl]carbamate
  • [(1R,3AR,4aR,6R,8aR,9S,9aS)-9-[(1E)-2-[5-(3-fluorophenyl)-2-pyridinyl]ethenyl]dodecahydro-1-me
  • Carbamic acid, N-[(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(1E)-2-[5-(3-fluorophenyl)-2-pyridinyl]ethenyl]dodecahydro-1-methyl-3-oxonaphtho[2,3-c]furan-6-yl]-, ethyl ester
  • CS-1663
  • CS-2015
  • MK-5348
  • ethyl((1R,3aR,4aR,8aR,9aS)-9-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl)carbamate
  • Vorapaxar D5Q: What is Vorapaxar D5 Q: What is the CAS Number of Vorapaxar D5 Q: What is the storage condition of Vorapaxar D5 Q: What are the applications of Vorapaxar D5
  • TIANFUCHEM--618385-01-6--Vorapaxar
  • 7-Dihydrocapsaicin
  • Vorapaxar free base
  • Vorapaxar (MK-5348)
  • 618385-01-6
  • C29H33FN2O4
  • API