PVM/MA

Product Name: PVM/MA
CAS No.: 1644545-52-7
Chemical Name: PVM/MA
Synonyms: E7386;AG881;AG081;HS-01;E-7386;PVM/MA;AG-881;s-22611;FF10101;CS-2621
CBNumber: CB91403717
Molecular Formula: C14H13ClF6N6
Formula Weight: 414.74
MOL File: 1644545-52-7.mol

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PVM/MA Property

Boiling point:: 467.5±55.0 °C(Predicted)
Density: 1.491±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml
form: A crystalline solid
pka: 1.49±0.41(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 28462
Product name: Vorasidenib
Packaging: 1mg
Price: $110
Updated: 2024/03/01

Cayman Chemical

Product number: 28462
Product name: Vorasidenib
Packaging: 10mg
Price: $757
Updated: 2024/03/01

Cayman Chemical

Product number: 28462
Product name: Vorasidenib
Packaging: 5mg
Price: $433
Updated: 2024/03/01

ChemScene

Product number: CS-8033
Product name: Vorasidenib
Purity: 99.87%
Packaging: 5mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-8033
Product name: Vorasidenib
Purity: 99.87%
Packaging: 10mg
Price: $250
Updated: 2021/12/16

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PVM/MA Chemical Properties,Usage,Production

Uses

PF-06291874 is a novel and potent glucagon receptor antagonist for the potential treatment of diabetes mellitus. PF-06291874, has a lower molcular weight and lipophilicity than historical glucagon receptor antagonists, resulting in excellent selectivity in broad-panel screening, lower cytotoxicity, and excellent overall in vivo safety in early pre-clinical testing.

Synthesis

Maleic anhydride (MA) was added to a solvent mixture of cyclohexane and ethyl acetate in a polymerizer equipped with an agitator, a reflux condenser, and an inner temperature-controlling device. The polymerizer was purged of air and filled with nitrogen. The solution was heated to 70 °C, and then an initiator solution (lauroyl peroxide dissolved in ethyl acetate) and Methyl vinyl ether (MVE) were added to the polymerizer in a dropwise manner. A slurry was obtained, which was filtered and dried under a vacuum to obtain a white powdery copolymer.

PVM/MA Preparation Products And Raw materials

Raw materials

Preparation Products

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PVM/MA Suppliers

China 77 India 5 United States 9 Global 91

Shanghai Aocheng Biological Technology Co., Ltd.

Tel: 13917627064
Fax: -qq：56229367
Email: 56229367@qq.com
Country: China
ProdList: 559
Advantage: 58

Wuhan Shanhai Zhihe Biotechnology Co., Ltd.

Tel: 17771424646
Email: shoubull@126.com
Country: China
ProdList: 965
Advantage: 58

Shanghai Hope Chem Co., Ltd.，

Tel: +21-18501659228 18501659228
Fax: sales@hope-chem.com
Email: info@hope-chem.com
Country: China
ProdList: 429
Advantage: 55

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2923
Advantage: 55

WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

Tel: 17702719238 17702719238
Email: sales@sun-shinechem.com
Country: China
ProdList: 905
Advantage: 64

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4121
Advantage: 55

BOC Sciences

Tel: 16314854226
Email: info@bocsci.com
Country: United States
ProdList: 9926
Advantage: 65

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 3444
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

ChengDu TongChuangYuan Pharmaceutical Co.Ltd

Tel: 028-83379370 13880556291
Fax: 028-87747383
Email: tcy@tcypharm.com
Country: China
ProdList: 5426
Advantage: 58

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View Lastest Price from PVM/MA manufacturers

Wuhan Nutra Biotechnology Co.,Ltd

Product: Vorasidenib;AG-881 1644545-52-7
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 100kgs
Release date: 2021-05-24

1644545-52-7, PVM/MARelated Search:

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PF06291874

Vorasidenib

E7386

E-7386

s-22611

FM381 FM-381

6-(6-chloropyridin-2-yl)-N2,N4-bis((R)-1,1,1-trifluoropropan-2-yl)-1,3,5-triazine-2,4-diamine

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15-HPETE

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4-(2-acetyl-5-chlorophenyl)-5-methoxypyridin-2(1H)-one

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FF10101

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benzyl ester of L-carnitine

CS-2621

AG 881; AG-881

3-bromo-5-bromoacetyl salicylamide

(R)-1-(3-(3-amino-6-(2-fluoro-5-isopropoxyphenyl)pyrazine-2-carboxamido)pyridin-4-yl)piperidine-3-carboxylic acid?

N,N-dimethyl-N-(oxiran-2-ylmethyl)octadecan-1-aminium chloride

Vorasidenib (AG881)

Trichloroethyl 2-(Bromomethyl)-2-hydroxyhehahydrofuro(3,2-b)pyridine-4(2H)-carboxylate

2-[3-(2H-indazol-3-ylmethyl)-2,4-dioxo-5-phenyl-1,5-benzodiazepin-1-yl]-N-(4-methoxyphenyl)-N-propan-2-ylacetamide

2,2'-(propane-2,2- diylbis(sulfanediyl))bis(ethan-1-ol)

(E)-Ethyl Docos-2-Enoate

HS-01

1,3,5-Triazine-2,4-diamine, 6-(6-chloro-2-pyridinyl)-N2,N4-bis[(1R)-2,2,2-trifluoro-1-methylethyl]-

2-[1-(2-Hydroxy-ethylsulfanyl)-1-methyl-ethylsulfanyl]-ethanol

4-N-(2,4-dimethoxyphenyl)-6-N-(4-(4-methylpiperazin-1-yl)phenyl)pyrimidine-4,6-diamine, N4-(2,4-dimethoxyphenyl)-N6-(4-(4-methylpiperazin-1-yl)phenyl)pyrimidine-4,6-diamine

IMB-XH1

2-chloro-N1,N4-bis(4-cyanophenyl)terephthalamide

(+)-Quassin

high quality 3-aminophenylacetylene HCL

Sodium 2,3,3,3-Tetrafluoro-2-(1,1,2,2,2-Pentafluoroethoxy)propanoate

2‐{2‐[2‐(2,2‐difluoroethoxy)ethoxy]ethoxy}‐1,1‐difluoroethane

4-hydrazineylnicotinamide

inhibit,AG 881,Vorasidenib,AG881,Inhibitor,Isocitrate Dehydrogenase (IDH)

SRD5A1-IN-1

AKR1C3-IN-9

ARUK2001607

TLC Plates,Silca Gel 60 F254 Aluminium Plating

2-(1-ethoxyvinyl)-4,4,5,5-tetraethyl-1,3,2-dioxaborolane

(S)-1-amino-1-(5-bromo-2-fluorophenyl)ethan-1-ol

N-Difluoromethyltriazolyl-4-carboxamide

N-Trifluoromethyltriazolyl-4-carboxamide

4-Cyano-1-(perfluoroethoxy)pyridin-1-ium bis((trifluoromethyl)sulfonyl)amide

Sodium 2-azido-2,2-difluoroacetate

(1-(2,2,3,3-Tetrafluoropropyl)-1H-1,2,3-triazol-4-yl)methanaminium chloride

1-Difluoroethyltriazolyl-4-methylamine hydrochloride