Vorapaxar
- Product Name
- Vorapaxar
- CAS No.
- 618385-01-6
- Chemical Name
- Vorapaxar
- Synonyms
- MK-5348;[(1R,3aR,4aR,6R,8aR,9S,9aS)-9-[(1E)-2-[5-(3-Fluorophenyl)-2-pyridinyl]ethenyl]dodecahydro-1-methyl-3-oxonaphtho[2,3-c]furan-6-yl]-carbamic acid ethyl ester;CS-2015;CS-1663;Vorapaxar;Voarapaxar;7-Dihydrocapsaicin;Vorapaxar free base;Vorapaxar (MK-5348);Vorapaxar (SCH 530348)
- CBNumber
- CB32628522
- Molecular Formula
- C29H33FN2O4
- Formula Weight
- 492.58
- MOL File
- 618385-01-6.mol
Vorapaxar Property
- Boiling point:
- 676.0±55.0 °C(Predicted)
- Density
- 1.24±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20° C
- solubility
- ≥24.65 mg/mL in DMSO; insoluble in H2O; ≥10.64 mg/mL in EtOH with ultrasonic
- form
- solid
- pka
- 12.49±0.60(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H371May cause damage to organs
H373May cause damage to organs through prolonged or repeated exposure
H400Very toxic to aquatic life
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P309+P311IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P314Get medical advice/attention if you feel unwell.
P391Collect spillage. Hazardous to the aquatic environment
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 23119
- Product name
- Vorapaxar
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 23119
- Product name
- Vorapaxar
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $208
- Updated
- 2024/03/01
- Product number
- A8809
- Product name
- Vorapaxar
- Packaging
- 1unit
- Price
- $28
- Updated
- 2021/12/16
- Product number
- Y1927
- Product name
- Vorapaxar
- Packaging
- 1mg
- Price
- $51
- Updated
- 2021/12/16
- Product number
- A8809
- Product name
- Vorapaxar
- Packaging
- 5mg
- Price
- $137
- Updated
- 2021/12/16
Vorapaxar Chemical Properties,Usage,Production
Description
Vorapaxar is an orally bioavailable competitive antagonist of the proteinase-activated receptor (PAR1; Ki = 8.1 nM), also known as the thrombin receptor. It is selective for PAR1 over other PARs, as well as a number of GPCRs, ion channels, and receptors. It inhibits platelet aggregation induced by thrombin and haTRAP (IC50s = 47 and 25 nM, respectively). Vorapaxar (0.1 mg/kg, i.v.) completely inhibits platelet aggregation in cynomolgus monkeys ex vivo. Formulations containing vorapaxar are used in the prevention of thrombotic cardiovascular events.
Definition
ChEBI: A carbamate ester that is the ethyl ester of [(1R,3aR,4aR,6R,8aR,9S,9aS)-9-{(E)-2-[5-(3-fluorophenyl)pyridin-2-yl]ethyny }-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-yl]carbamic acid. A protease-activated receptor-1 antagonist used (as its sulfate salt) for the reduction of thrombotic cardiovascular events in patients with a history of myocardial infarction MI) or with peripheral arterial disease. It has been shown to reduce the rate of a combined endpoint of cardiovascular death, MI, stroke and urgent coronary revascularisation.
References
[1]. chackalamannil s & xia, y. thrombin receptor (par-1) antagonists as novel antithrombotic agents. expert opinion on therapeutic patents, 2006.16:493-505.
[2]. chackalamannil s, wang y, greenlee w j et al. 2008. discovery of a novel, orally active himbacine-based thrombin receptor antagonist (sch 530348) with potent antiplatelet activity. j med chem, 2008,51: 3061-3064.
Vorapaxar Preparation Products And Raw materials
Raw materials
Preparation Products
Vorapaxar Suppliers
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View Lastest Price from Vorapaxar manufacturers
- Product
- Vorapaxar 618385-01-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 500KG
- Release date
- 2021-09-16
- Product
- Vorapaxar 618385-01-6
- Price
- US $1.00/KG
- Min. Order
- 1G
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-08-21