Tetrahydro-4-oxo-3-furoic acid ethyl ester
- Product Name
- Tetrahydro-4-oxo-3-furoic acid ethyl ester
- CAS No.
- 89898-51-1
- Chemical Name
- Tetrahydro-4-oxo-3-furoic acid ethyl ester
- Synonyms
- Ethyl 4-oxooxolane-3-carboxylate;Tetrahydro-4-oxo-3-furoic acid ethyl ester;Ethyl 4-Oxotetrahydrofuran-3-Carboxylate(WX618533);4-Oxo-tetrahydro-furan-3-carboxylic acid ethyl ester;3-Furancarboxylic acid, tetrahydro-4-oxo-, ethyl ester
- CBNumber
- CB32630024
- Molecular Formula
- C7H10O4
- Formula Weight
- 158.15
- MOL File
- 89898-51-1.mol
Tetrahydro-4-oxo-3-furoic acid ethyl ester Property
- Boiling point:
- 237℃
- Density
- 1.213
- Flash point:
- 99℃
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 10.75±0.20(Predicted)
- Appearance
- Colorless to light yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- E927545
- Product name
- Ethyl4-oxotetrahydrofuran-3-carboxylate
- Packaging
- 100mg
- Price
- $240
- Updated
- 2021/12/16
- Product number
- 4919AC
- Product name
- Ethyl4-oxotetrahydrofuran-3-carboxylate
- Packaging
- 25g
- Price
- $2737
- Updated
- 2021/12/16
- Product number
- CHM0392539
- Product name
- ETHYL-4-OXOTETRAHYDROFURAN-3-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.23
- Updated
- 2021/12/16
- Product number
- CM128957
- Product name
- ethyl4-oxotetrahydrofuran-3-carboxylate
- Purity
- 97%
- Packaging
- 5g
- Price
- $597
- Updated
- 2021/12/16
- Product number
- 05R0717
- Product name
- 4-Oxo-tetrahydro-furan-3-carboxylicacidethylester
- Purity
- 97%
- Packaging
- 1g
- Price
- $598
- Updated
- 2021/12/16
Tetrahydro-4-oxo-3-furoic acid ethyl ester Chemical Properties,Usage,Production
Synthesis
623-50-7
140-88-5
89898-51-1
Step 1- Synthesis of ethyl 4-oxotetrahydrofuran-3-carboxylate (ge). NaH (60%, 4.6 g, 116 mmol) was suspended in anhydrous ether (200 mL) and cooled in an ice bath to 0°C. Ethyl ethanoate (10 mL, 100 mmol) was added slowly and dropwise to this suspension under nitrogen protection. The resulting white slurry was stirred at room temperature for 45 minutes. Subsequently, the ethyl ether was removed under reduced pressure to give a white solid. The solid was resuspended in DMSO (130 mL), cooled to 0°C in an ice bath, and then ethyl acrylate (13.7 mL, 127 mmol) was added slowly and dropwise. The resulting yellow colored mixture was stirred at room temperature overnight (~12 hours). After the reaction was completed, the reaction solution was slowly poured into 10% aqueous HCl solution (500 mL). Extraction was carried out with ether (3 x 200 mL). The ether extracts were combined, washed with saturated saline, dried over anhydrous MgSO4, filtered and concentrated under reduced pressure to afford 14 g (80% yield) of the target product ethyl 4-oxotetrahydrofuran-3-carboxylate (ge) as a clarified yellow liquid. The product was used directly in the next reaction without further purification.
References
[1] Patent: US2010/331305, 2010, A1. Location in patent: Page/Page column 80-81
[2] Patent: WO2004/26864, 2004, A1. Location in patent: Page 129; 130
[3] Patent: WO2014/15291, 2014, A1. Location in patent: Page/Page column 181
Tetrahydro-4-oxo-3-furoic acid ethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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