METHYL TETRAHYDRO-4-OXO-2H-THIOPYRAN-3-CARBOXYLATE

Uses

Product Name: METHYL TETRAHYDRO-4-OXO-2H-THIOPYRAN-3-CARBOXYLATE
CAS No.: 4160-61-6
Chemical Name: METHYL TETRAHYDRO-4-OXO-2H-THIOPYRAN-3-CARBOXYLATE
Synonyms: 3-Methoxycarbonyl-4-thianone;Methyl 4-oxothiane-3-carboxylate;3-methoxycarbonyltetrahydropyran-4-one;3-Carbomethoxytetrahydro-1,4-thiapyrone;3-(Carbomethoxy)tetrahydrothiopyran-4-one;4-oxotetrahydro-2H-thiopyran-3-carboxylate;Methyl 4-oxotetrahydrothiopyran-3-carboxylate;ETHYL TETRAHYDRO-4-OXO-2H-THIOPYRAN-3-CARBOXYLATE;methyl 4-oxo-tetrahydro-2H-thiopyran-3-carboxylate;METHYL TETRAHYDRO-4-OXO-2H-THIOPYRAN-3-CARBOXYLATE
CBNumber: CB4807180
Molecular Formula: C7H10O3S
Formula Weight: 174.22
MOL File: 4160-61-6.mol

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METHYL TETRAHYDRO-4-OXO-2H-THIOPYRAN-3-CARBOXYLATE Property

Boiling point:: 285℃
Density: 1.244
Flash point:: 137℃
storage temp.: Sealed in dry,Room Temperature
pka: 10.41±0.20(Predicted)
form: Liquid or Solid
color: Clear colorless to pale yellow

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Safety

Risk Statements: 36/37/38
Safety Statements: 23-26-36/37/39
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: CHM0096325
Product name: METHYL TETRAHYDRO-4-OXO-2H-THIOPYRAN-3-CARBOXYLATE
Purity: 95.00%
Packaging: 1G
Price: $765.23
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0096325
Product name: METHYL TETRAHYDRO-4-OXO-2H-THIOPYRAN-3-CARBOXYLATE
Purity: 95.00%
Packaging: 2.5G
Price: $1065.66
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK668695
Product name: Methyltetrahydro-4-oxo-2H-thiopyran-3-carboxylate
Purity: 96%
Packaging: 1g
Price: $277
Updated: 2021/12/16

Apolloscientific

Product number: OR946543
Product name: Methyltetrahydro-4-oxo-2H-thiopyran-3-carboxylate
Purity: 95%
Packaging: 1g
Price: $285
Updated: 2021/12/16

Matrix Scientific

Product number: 099418
Product name: Methyl 4-oxotetrahydro-2H-thiopyran-3-carboxylate
Purity: 95+%
Packaging: 250mg
Price: $189
Updated: 2021/12/16

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METHYL TETRAHYDRO-4-OXO-2H-THIOPYRAN-3-CARBOXYLATE Chemical Properties,Usage,Production

Uses

Methyl tetrahydro-4-oxo-2H-thiaran-3-carboxylic acid is a carboxylic acid ester derivative that can be used as an organic intermediate.

Chemical Properties

Light pink liquid

Synthesis

4131-74-2

4160-61-6

General procedure for the synthesis of methyl tetrahydro-4-oxo-2H-thiopyran-3-carboxylate from dimethyl 3,3'-thiodipropionate: 2.7098 g of NaH (60%) was added to a dry 250 ml three-necked flask, followed by the addition of 40 ml of anhydrous tetrahydrofuran (THF) and stirring for 10 min at room temperature. Dimethyl 3,3'-thiodipropionate (10.1015 g) dissolved in THF was added slowly dropwise. After dropwise addition, the reaction mixture was heated to reflux for about 1 hour. The reflux was continued for 1 hour after rinsing the dropping funnel with 10 ml of THF. The reaction was stopped and cooled to room temperature. The pH of the reaction solution was adjusted to 6-7 with 2% hydrochloric acid and then extracted with dichloromethane (30 ml x 3). The organic layers were combined, washed with saturated sodium chloride solution, collected and dried over anhydrous sodium sulfate. After filtration, the solvent was removed under reduced pressure to give 7.5639 g of a yellow oily liquid product in 88.7% yield.

References

[1] Synthesis, 2007, # 10, p. 1584 - 1586
[2] Patent: CN104086562, 2016, B. Location in patent: Paragraph 0136; 0137
[3] Patent: CN105153190, 2017, B. Location in patent: Paragraph 0134; 0165; 0166
[4] Organic Letters, 2018, vol. 20, # 19, p. 6104 - 6107
[5] Journal of the American Chemical Society, 1997, vol. 119, # 18, p. 4285 - 4291

METHYL TETRAHYDRO-4-OXO-2H-THIOPYRAN-3-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Sodium hydride Sodium sulfate Sodium chloride SODIUM HYDROSULFIDE HYDRATE Sodium Tetrahydrofuran Diethyl ether Ethyl acetate Sodium bicarbonate Acetic acid Methanol Sodium hydrosulfide Methyl acrylate

Preparation Products

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METHYL TETRAHYDRO-4-OXO-2H-THIOPYRAN-3-CARBOXYLATE Suppliers

China 75 Germany 1 India 1 South Korea 1 United Kingdom 1 United States 6 Global 85

J & K SCIENTIFIC LTD.

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View Lastest Price from METHYL TETRAHYDRO-4-OXO-2H-THIOPYRAN-3-CARBOXYLATE manufacturers

Dideu Industries Group Limited

Product: METHYL TETRAHYDRO-4-OXO-2H-THIOPYRAN-3-CARBOXYLATE 4160-61-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-29

Career Henan Chemical Co

Product: ETHYL TETRAHYDRO-4-OXO-2H-THIOPYRAN-3-CARBOXYLATE 4160-61-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1ton
Release date: 2019-07-09

4160-61-6, METHYL TETRAHYDRO-4-OXO-2H-THIOPYRAN-3-CARBOXYLATERelated Search:

2H-Thiopyran-4-carboxylic acid, tetrahydro-, Methyl ester, 1,1-dioxide 1,1-Dioxo-hexahydro-1l6-thiopyran-4-carboxylic acid DELTA-TRIDECANOLACTONE Tetrahydro-2H-pyran-4-yl methanesulfonate 2-HYDROXYTETRAHYDROPYRAN Methyl 2-oxotetrahydrofuran-3-carboxylate Tetrahydro-5-oxo-2- furancarboxyli Tetrahydro-2H-thiopyran-4-amine ethyl tetrahydro-2H-pyran-2-carboxylate METHYL TETRAHYDROPYRAN-3-CARBOXYLATE Thian-4-one S-oxide Tetrahydrothiopyran-4-one oxiMe Tetrahydro-4-oxo-3-furoic acid ethyl ester Tetrahydropyran-4-boronic acid pinacol ester METHYL TETRAHYDRO-4-OXO-2H-THIOPYRAN-3-CARBOXYLATE Thiane Tetrahydrothiopyran-4-one ETHYL 4-OXO-TETRAHYDRO-3-THIOPYRANCARBOXYLATE

METHYL TETRAHYDRO-4-OXO-2H-THIOPYRAN-3-CARBOXYLATE

4-OXO-TETRAHYDRO-THIOPYRAN-3-CARBOXYLIC ACID METHYL ESTER

Methyl tetrahydro-4-oxo-2H-thiopyran-3-carboxylate ,96%

Methyl 4-oxotetrahydrothiopyran-3-carboxylate

3-(Carbomethoxy)tetrahydrothiopyran-4-one

3-Carbomethoxytetrahydro-1,4-thiapyrone

3-Methoxycarbonyl-4-thianone

methyl 4-oxo-tetrahydro-2H-thiopyran-3-carboxylate

2H-Thiopyran-3-carboxylic acid, tetrahydro-4-oxo-, Methyl ester

Methyletetrahydro-4-oxo-2H-thiopyran-3-carboxylate

Methyl 4-oxothiane-3-carboxylate

ETHYL TETRAHYDRO-4-OXO-2H-THIOPYRAN-3-CARBOXYLATE

METHYL TETRAHYDRO-4-OXO-2H-THIOPYRAN-3-CARBOXYLATE ISO 9001：2015 REACH

4-oxotetrahydro-2H-thiopyran-3-carboxylate

3-methoxycarbonyltetrahydropyran-4-one

4160-61-6

C7H10O3S