Tetrahydro-2H-pyran-4-yl methanesulfonate

Product Name: Tetrahydro-2H-pyran-4-yl methanesulfonate
CAS No.: 134419-59-3
Chemical Name: Tetrahydro-2H-pyran-4-yl methanesulfonate
Synonyms: Tetrahydropyran-4-yl methanesulfonate;oxan-4-yl methanesulfonate;4-Tetrahydropyranyl Methanesulfonat;4-Tetrahydropyranyl Methanesulfonate;4-(Methylsulfonyloxy)tetrahydropyran;4-Tetrahydropyranylmethanesulfonate,95%;Tetrahydro-1H-pyran-4-yl methanesulfonate;Tetrahydro-2H-pyran-4-ylmethanesulphonate;4-Tetrahydropyranyl Methanesulfonate, 95%;Tetrahydro-2H-pyran-4-yl methanesulfonate
CBNumber: CB71873912
Molecular Formula: C6H12O4S
Formula Weight: 180.22
MOL File: 134419-59-3.mol

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Tetrahydro-2H-pyran-4-yl methanesulfonate Property

Melting point:: 47-49°C
Boiling point:: 329.1±31.0 °C(Predicted)
Density: 1.26±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: Dichlromethane, DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form: Solid
color: Off-White to Pale Beige
Stability:: Moisture Sensitive
InChI: InChI=1S/C6H12O4S/c1-11(7,8)10-6-2-4-9-5-3-6/h6H,2-5H2,1H3
InChIKey: GSEZHCLWHDZJAB-UHFFFAOYSA-N
SMILES: C1OCCC(OS(C)(=O)=O)C1

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Safety

HS Code: 2932990090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: T795193
Product name: Tetrahydro-2H-pyran-4-ylMethanesulfonate
Packaging: 2.5g
Price: $300
Updated: 2021/12/16

AK Scientific

Product number: J97542
Product name: Tetrahydro-2H-pyran-4-ylmethanesulfonate
Packaging: 1g
Price: $49
Updated: 2021/12/16

ChemScene

Product number: CS-0046812
Product name: Tetrahydro-2H-pyran-4-ylmethanesulfonate
Purity: ≥97.0%
Packaging: 5g
Price: $57
Updated: 2021/12/16

ChemScene

Product number: CS-0046812
Product name: Tetrahydro-2H-pyran-4-ylmethanesulfonate
Purity: ≥97.0%
Packaging: 10g
Price: $108
Updated: 2021/12/16

SynQuest Laboratories

Product number: 6H64-1-08
Product name: Tetrahydro-2H-pyran-4-yl methanesulfonate
Packaging: 1g
Price: $119
Updated: 2021/12/16

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Tetrahydro-2H-pyran-4-yl methanesulfonate Chemical Properties,Usage,Production

Uses

Tetrahydro-2H-pyran-4-yl Methanesulfonate is an intermediate in the synthesis of 3,4,5-Trimethoxy-2-nitro Acetophenone (T795510). 3,4,5-Trimethoxy-2-nitro acetophenone is an intermediate used to prepare substituted 4-alkyl-2(1H)-quinazolinones as potential cardiotonics. It can be also used as an intermediate to synthesize 2-Amino-3,4,5-trimethoxybenzophenones as potent tubulin polymerization inhibitors.

Synthesis

2081-44-9

124-63-0

134419-59-3

In 200 mL of dichloromethane, tetrahydro-2H-pyran-4-ol (15.83 g, 0.155 mol) was mixed with triethylamine (21.6 mL, 0.155 mol) and dimethylaminopyridine (1.89 g, 0.015 mol) was added as a catalyst. Methanesulfonyl chloride (12 mL, 0.155 mol) was slowly added dropwise at 0 °C. After the dropwise addition, the reaction mixture was gradually warmed up to room temperature and stirred continuously for 16 hours. After completion of the reaction, the organic phase was washed sequentially with deionized water and brine, and then dried with anhydrous magnesium sulfate. After filtration to remove the drying agent, the solvent was removed by distillation under reduced pressure to afford tetrahydro-2H-pyran-4-yl methanesulfonate (Compound 1010, 22.6 g, 80.9% yield) as a yellow solid. The product was characterized by 1H NMR (300 MHz, CDCl3): δ 4.90 (qn, J = 4.2 Hz, 1H), 3.95 (dt, J = 12.0, 4.2 Hz, 2H), 3.59-3.51 (m, 2H), 3.04 (s, 3H), 2.08-2.01 (m, 2H), 1.94-1.82 (m, 2H).

References

[1] Patent: US2009/156610, 2009, A1. Location in patent: Page/Page column 33
[2] Patent: US2010/210674, 2010, A1. Location in patent: Page/Page column 7-8
[3] Patent: US2014/45814, 2014, A1. Location in patent: Paragraph 0245; 0246
[4] Patent: WO2014/151106, 2014, A1. Location in patent: Paragraph 00187
[5] Patent: US2016/168156, 2016, A1. Location in patent: Paragraph 0503; 0504

Tetrahydro-2H-pyran-4-yl methanesulfonate Preparation Products And Raw materials

Raw materials

Preparation Products

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Tetrahydro-2H-pyran-4-yl methanesulfonate Suppliers

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View Lastest Price from Tetrahydro-2H-pyran-4-yl methanesulfonate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Tetrahydro-2H-pyran-4-yl methanesulfonate 134419-59-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 100kg
Release date: 2025-05-09

Henan Fengda Chemical Co., Ltd

Product: Tetrahydro-2H-pyran-4-yl methanesulfonate 134419-59-3
Price: US $31.00-1.50/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-10

134419-59-3, Tetrahydro-2H-pyran-4-yl methanesulfonateRelated Search:

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Tetrahydro-2H-pyran-4-yl methanesulfonate

4-Tetrahydropyranyl Methanesulfonate, 95%

Tetrahydro-2H-pyran-4-ylmethanesulphonate

2H-Pyran-4-ol, tetrahydro-, methanesulfonate

oxan-4-yl methanesulfonate

Tetrahydropyran-4-yl methanesulfonate

4-Tetrahydropyranylmethanesulfonate,95%

Tetrahydro-1H-pyran-4-yl methanesulfonate

4-Tetrahydropyranyl Methanesulfonat

4-(Methylsulfonyloxy)tetrahydropyran

4-Tetrahydropyranyl Methanesulfonate

134419-59-3

Pyrans, Piperidines & Piperazines