ChemicalBook > CAS DataBase List > Tetrahydro-2H-pyran-4-yl methanesulfonate

Tetrahydro-2H-pyran-4-yl methanesulfonate

Product Name
Tetrahydro-2H-pyran-4-yl methanesulfonate
CAS No.
134419-59-3
Chemical Name
Tetrahydro-2H-pyran-4-yl methanesulfonate
Synonyms
Tetrahydropyran-4-yl methanesulfonate;oxan-4-yl methanesulfonate;4-Tetrahydropyranyl Methanesulfonat;4-Tetrahydropyranyl Methanesulfonate;4-(Methylsulfonyloxy)tetrahydropyran;4-Tetrahydropyranylmethanesulfonate,95%;Tetrahydro-1H-pyran-4-yl methanesulfonate;Tetrahydro-2H-pyran-4-ylmethanesulphonate;4-Tetrahydropyranyl Methanesulfonate, 95%;Tetrahydro-2H-pyran-4-yl methanesulfonate
CBNumber
CB71873912
Molecular Formula
C6H12O4S
Formula Weight
180.22
MOL File
134419-59-3.mol
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Tetrahydro-2H-pyran-4-yl methanesulfonate Property

Melting point:
47-49°C
Boiling point:
329.1±31.0 °C(Predicted)
Density 
1.26±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Dichlromethane, DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form 
Solid
color 
Off-White to Pale Beige
Stability:
Moisture Sensitive
InChI
InChI=1S/C6H12O4S/c1-11(7,8)10-6-2-4-9-5-3-6/h6H,2-5H2,1H3
InChIKey
GSEZHCLWHDZJAB-UHFFFAOYSA-N
SMILES
C1OCCC(OS(C)(=O)=O)C1
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Safety

HS Code 
2932990090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
T795193
Product name
Tetrahydro-2H-pyran-4-ylMethanesulfonate
Packaging
2.5g
Price
$300
Updated
2021/12/16
Matrix Scientific
Product number
085481
Product name
Tetrahydro-2H-pyran-4-yl methanesulfonate
Purity
97%
Packaging
5g
Price
$525
Updated
2021/12/16
Matrix Scientific
Product number
085481
Product name
Tetrahydro-2H-pyran-4-yl methanesulfonate
Purity
97%
Packaging
1g
Price
$160
Updated
2021/12/16
AK Scientific
Product number
3865AD
Product name
Tetrahydro-2H-pyran-4-ylmethanesulfonate
Packaging
5g
Price
$267
Updated
2021/12/16
SynQuest Laboratories
Product number
6H64-1-08
Product name
Tetrahydro-2H-pyran-4-yl methanesulfonate
Packaging
5G
Price
$202
Updated
2021/12/16
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Tetrahydro-2H-pyran-4-yl methanesulfonate Chemical Properties,Usage,Production

Uses

Tetrahydro-2H-pyran-4-yl Methanesulfonate is an intermediate in the synthesis of 3,4,5-Trimethoxy-2-nitro Acetophenone (T795510). 3,4,5-Trimethoxy-2-nitro acetophenone is an intermediate used to prepare substituted 4-alkyl-2(1H)-quinazolinones as potential cardiotonics. It can be also used as an intermediate to synthesize 2-Amino-3,4,5-trimethoxybenzophenones as potent tubulin polymerization inhibitors.

Synthesis

2081-44-9

124-63-0

134419-59-3

In 200 mL of dichloromethane, tetrahydro-2H-pyran-4-ol (15.83 g, 0.155 mol) was mixed with triethylamine (21.6 mL, 0.155 mol) and dimethylaminopyridine (1.89 g, 0.015 mol) was added as a catalyst. Methanesulfonyl chloride (12 mL, 0.155 mol) was slowly added dropwise at 0 °C. After the dropwise addition, the reaction mixture was gradually warmed up to room temperature and stirred continuously for 16 hours. After completion of the reaction, the organic phase was washed sequentially with deionized water and brine, and then dried with anhydrous magnesium sulfate. After filtration to remove the drying agent, the solvent was removed by distillation under reduced pressure to afford tetrahydro-2H-pyran-4-yl methanesulfonate (Compound 1010, 22.6 g, 80.9% yield) as a yellow solid. The product was characterized by 1H NMR (300 MHz, CDCl3): δ 4.90 (qn, J = 4.2 Hz, 1H), 3.95 (dt, J = 12.0, 4.2 Hz, 2H), 3.59-3.51 (m, 2H), 3.04 (s, 3H), 2.08-2.01 (m, 2H), 1.94-1.82 (m, 2H).

References

[1] Patent: US2009/156610, 2009, A1. Location in patent: Page/Page column 33
[2] Patent: US2010/210674, 2010, A1. Location in patent: Page/Page column 7-8
[3] Patent: US2014/45814, 2014, A1. Location in patent: Paragraph 0245; 0246
[4] Patent: WO2014/151106, 2014, A1. Location in patent: Paragraph 00187
[5] Patent: US2016/168156, 2016, A1. Location in patent: Paragraph 0503; 0504

Tetrahydro-2H-pyran-4-yl methanesulfonate Preparation Products And Raw materials

Raw materials

Preparation Products

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Tetrahydro-2H-pyran-4-yl methanesulfonate Suppliers

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View Lastest Price from Tetrahydro-2H-pyran-4-yl methanesulfonate manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Tetrahydro-2H-pyran-4-yl methanesulfonate 134419-59-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
100kg
Release date
2025-05-09
Henan Fengda Chemical Co., Ltd
Product
Tetrahydro-2H-pyran-4-yl methanesulfonate 134419-59-3
Price
US $31.00-1.50/kg
Min. Order
1kg
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-04-10

134419-59-3, Tetrahydro-2H-pyran-4-yl methanesulfonateRelated Search:

TETRAHYDRO-PYRAN-3-YLAMINE HYDROCHLORIDE tetrahydro-2H-thiopyran-4-carbonitrile 1,1-dioxide(SALTDATA: FREE) TETRAHYDRO-THIOPYRAN-4-YLAMINE HYDROCHLORIDE 2H-Thiopyran-4-carboxylic acid, tetrahydro-, Methyl ester, 1,1-dioxide 1,1-Dioxo-hexahydro-1l6-thiopyran-4-carboxylic acid DELTA-TRIDECANOLACTONE Methyl 2-oxotetrahydrofuran-3-carboxylate Tetrahydro-5-oxo-2- furancarboxyli Tetrahydro-2H-thiopyran-4-amine METHYL TETRAHYDRO-4-OXO-2H-THIOPYRAN-3-CARBOXYLATE Thian-4-one S-oxide Tetrahydrothiopyran-4-one oxiMe 2H-PYRAN-3-AMINE, TETRAHYDRO- Tetrahydropyran-4-SulfonylChloride 2-HYDROXYTETRAHYDROPYRAN 4-Aminotetrahydropyran hydrochloride ethyl tetrahydro-2H-pyran-2-carboxylate METHYL TETRAHYDROPYRAN-3-CARBOXYLATE

  • Tetrahydro-2H-pyran-4-yl methanesulfonate
  • 4-Tetrahydropyranyl Methanesulfonate, 95%
  • Tetrahydro-2H-pyran-4-ylmethanesulphonate
  • 2H-Pyran-4-ol, tetrahydro-, methanesulfonate
  • oxan-4-yl methanesulfonate
  • Tetrahydropyran-4-yl methanesulfonate
  • 4-Tetrahydropyranylmethanesulfonate,95%
  • Tetrahydro-1H-pyran-4-yl methanesulfonate
  • 4-Tetrahydropyranyl Methanesulfonat
  • 4-(Methylsulfonyloxy)tetrahydropyran
  • 4-Tetrahydropyranyl Methanesulfonate
  • 134419-59-3
  • Pyrans, Piperidines & Piperazines