ChemicalBook > CAS DataBase List > IOX2

IOX2

Product Name
IOX2
CAS No.
931398-72-0
Chemical Name
IOX2
Synonyms
IOX2;JICL38;CS-564;IOX 2, >=98%;IOX2(Glycine);IOX-2; IOX2; IOX 2;DesidustatImpurity1;IOX2;IOX 2;IOX-2;JICL38;(1-benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbonyl)glycine;2-[(1-BENZYL-4-HYDROXY-2-OXOQUINOLINE-3-CARBONYL)AMINO]ACETIC ACID
CBNumber
CB32638323
Molecular Formula
C19H16N2O5
Formula Weight
352.34
MOL File
931398-72-0.mol
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IOX2 Property

Boiling point:
642.8±55.0 °C(Predicted)
Density 
1.470±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble5mg/mL, clear (warmed)
pka
3.61±0.10(Predicted)
form 
powder
color 
white to beige
InChIKey
CAOSCCRYLYQBES-UHFFFAOYSA-N
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0652
Product name
IOX2
Purity
≥98% (HPLC)
Packaging
5mg
Price
$119
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0652
Product name
IOX2
Purity
≥98% (HPLC)
Packaging
25mg
Price
$481
Updated
2024/03/01
Cayman Chemical
Product number
11573
Product name
IOX2
Purity
≥98%
Packaging
5mg
Price
$68
Updated
2024/03/01
Cayman Chemical
Product number
11573
Product name
IOX2
Purity
≥98%
Packaging
10mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
11573
Product name
IOX2
Purity
≥98%
Packaging
25mg
Price
$169
Updated
2024/03/01
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IOX2 Chemical Properties,Usage,Production

Uses

IOX2 is a potent inhibitor of HIF-1α prolyl hydroxylase-2 (PHD2) with IC50 of 21 nM.

Uses

IOX2 has been used as PHD inhibitor to induce pseudo-hypoxia.

Definition

ChEBI: 2-[[[4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]-oxomethyl]amino]acetic acid is a member of quinolines.

Biological Activity

iox2 is a potent and selective inhibitor of hif-1α prolyl hydroxylase-2 (phd2) with an ic50 of 21 nm for phd2/elgn-1 in a cell-free assay, iox2 has shown >100-fold selectivity over jmjd2a, jmjd2c, jmjd2e, jmjd3, or the 2og oxygenase fih [1].phds consist three isoforms, named phd1, phd2 and phd3. phds are dioxygenases that utilize oxygen as co-substrate providing the molecular basis for the oxygen-sensing function of these enzymes. it has been reported that phds are strikingly sensitive to graded levels of hypoxia, mirroring the progressive increases in hif-1α protein and dna binding activity that are observed when cells are exposed to gradual hypoxia [2]. in rcc4 cells, iox2 inhibited hif-1α hydroxylation at 50 μm [1].

Biochem/physiol Actions

IOX2 is selective and potent inhibitor of prolyl hydroxylases (PHD). Stabilization of HIF-1R through inhibition of PHD has been examined as a potential treatment for ischemic diseases including anemia, myocardial infarction, and stroke. IOX2 is a selective inhibitor of the hypoxia inducible factor (HIF) prolyl-hydroxylases (PHD) that exhibits up-regulation of HIF1a in zebrafish. For full characterization details, please visit the IOX2 probe summary on the Structural Genomics Consortium (SGC) website.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc

storage

Store at +4°C

References

[1] murray j k, balan c, allgeier a m, et al. dipeptidyl-quinolone derivatives inhibit hypoxia inducible factor-1α prolyl hydroxylases-1,-2, and-3 with altered selectivity[j]. journal of combinatorial chemistry, 2010, 12(5): 676-686.
[2] berra e, benizri e, ginouvès a, et al. hif prolyl‐hydroxylase 2 is the key oxygen sensor setting low steady‐state levels of hif‐1α in normoxia[j]. the embo journal, 2003, 22(16): 4082-4090.

IOX2 Preparation Products And Raw materials

Raw materials

Preparation Products

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IOX2 Suppliers

China 100 India 2 United Kingdom 1 United States 22 Global 125
Shanghai Boyle Chemical Co., Ltd.
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View Lastest Price from IOX2 manufacturers

Career Henan Chemical Co
Product
IOX2 931398-72-0
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2019-07-09
Career Henan Chemical Co
Product
E6005 931398-72-0
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2019-07-09
Career Henan Chemical Co
Product
E6005 947620-48-6
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100KG
Release date
2019-07-09

931398-72-0, IOX2Related Search:

Roxadustat 2-METHOXYESTRADIOL Trametinib BAY 87-2243 GO 6976 Olaparib

  • Glycine, N-[[1,2-dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]-
  • N-[[4-Hydroxy-2-oxo-1-(phenylmethyl)-1,2-dihydro-3-quinolinyl]carbonyl]glycine IOX2
  • JICL38
  • N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]-glycine
  • (1-benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbonyl)glycine
  • IOX 2, >=98%
  • IOX2;IOX 2;IOX-2;JICL38
  • IOX2
  • 2-(1-benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxaMido)acetic acid
  • 2-[(1-BENZYL-4-HYDROXY-2-OXOQUINOLINE-3-CARBONYL)AMINO]ACETIC ACID
  • N-[[4-Hydroxy-2-oxo-1-(phenylmethyl)-1,2-dihydro-3-quinolinyl]carbonyl]glycine
  • IOX2(Glycine)
  • IOX-2; IOX2; IOX 2
  • CS-564
  • DesidustatImpurity1
  • HIF-PH,Inhibitor,inhibit,HIF/HIF Prolyl-Hydroxylase,IOX-2,IOX2,HIFs,Hypoxia-inducible factors
  • 931398-72-0
  • Inhibitors
  • Inhibitor