GUANABENZ
- Product Name
- GUANABENZ
- CAS No.
- 5051-62-7
- Chemical Name
- GUANABENZ
- Synonyms
- Rexitene;GUANABENZ;nsc-68982;Callosum benzyl;GUANABENZ USP/EP/BP;Guanabenz (WY 8678);1-(2,6-DICHLOROBENZYLIDENEAMINO)GUANIDINE;n-(2,6-dichlorobenzylidene)amino]guanidine;n-(2,6-dichlorobenzylidene)-n’-amidinohydrazine;2-(2,6-Dichlorobenzylidene)hydrazine-1-carboximidamide
- CBNumber
- CB3263851
- Molecular Formula
- C8H8Cl2N4
- Formula Weight
- 231.08
- MOL File
- 5051-62-7.mol
GUANABENZ Property
- Melting point:
- 227-229° (dec)
- Boiling point:
- 353.9±52.0 °C(Predicted)
- Density
- 1.49±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 12 mg/mL (51.93 mM);Ethanol: 15 mg/mL (64.91 mM)
- pka
- pKa 8.1 (Uncertain)
- Water Solubility
- Water: Insoluble
Safety
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-62
- Safety Statements
- 22-36/37/39
- RIDADR
- 3249
- WGK Germany
- 3
- HazardClass
- 6.1(b)
- PackingGroup
- III
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P281Use personal protective equipment as required.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P322Specific measures (see …on this label).
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- S762091
- Product name
- N-(2,6-DICHLOROBENZYLIDENEAMINO)GUANIDINE
- Purity
- Aldrich
- Packaging
- 50mg
- Price
- $179
- Updated
- 2024/03/01
- Product number
- API0006231
- Product name
- GUANABENZ
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.68
- Updated
- 2021/12/16
- Product number
- 75138
- Product name
- Guanabenz
- Packaging
- 5mg
- Price
- $1545
- Updated
- 2021/12/16
- Product number
- CSN23785
- Product name
- GUANABENZ
- Packaging
- 100mg
- Price
- $237
- Updated
- 2021/12/16
- Product number
- MT-08425
- Product name
- 1-(2,6-Dichlorobenzylideneamino)guanidine
- Purity
- 98%
- Packaging
- 0.1g
- Price
- $306
- Updated
- 2021/12/16
GUANABENZ Chemical Properties,Usage,Production
Description
Guanabenz is an α2-adrenergic agonist that exhibits pronounced hypotensive action, and that is associated with a reduction of overall peripheral vascular resistance, decline in frequency of cardiac contractions, and reduced cardiac output.
Originator
Wytensin,Wyeth,US,1982
Uses
alpha agonists
Uses
It is used both independently and in combination with oral diuretics for treating various degrees of hypertension.
Definition
ChEBI: Guanabenz is a dichlorobenzene.
Manufacturing Process
A mixture of 14.0 g of 2,6-dichlorobenzaldehyde, 10.8 g of aminoguanidine bicarbonate and 100 ml of pyridine was refluxed for 3 hours. The reaction mixture was poured into water and the crystalline precipitate filtered off; MP 225°C to 227°C.
Therapeutic Function
Antihypertensive
Synthesis
Guanabenz, [(2,6-dichlorobenzyliden) amino] guanidine (22.3.1), is synthesized in one step by reacting 2,6-dichlorobenzaldehyde with amino guanidine.
Purification Methods
Crystallise the guanidine from MeCN and store it in a CO2–free atmosphere. The monoHCl [23256-5-0] has m 178o(dec) [solubility w% at 25o is 1.1(H2O), 5(EtOH), 0.1(EtOAc), 0.06(CHCl3)]. It is an antihypertensive drug. [Holmes et al. Drugs 26 212 1983.]
GUANABENZ Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from GUANABENZ manufacturers
- Product
- GUANABENZ 5051-62-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-10
- Product
- Guanabenz 5051-62-7
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 500 MT
- Release date
- 2020-05-09