GUANABENZ

Product Name: GUANABENZ
CAS No.: 5051-62-7
Chemical Name: GUANABENZ
Synonyms: Rexitene;GUANABENZ;nsc-68982;Callosum benzyl;GUANABENZ USP/EP/BP;Guanabenz (WY 8678);1-(2,6-DICHLOROBENZYLIDENEAMINO)GUANIDINE;n-(2,6-dichlorobenzylidene)amino]guanidine;n-(2,6-dichlorobenzylidene)-n’-amidinohydrazine;2-(2,6-Dichlorobenzylidene)hydrazine-1-carboximidamide
CBNumber: CB3263851
Molecular Formula: C8H8Cl2N4
Formula Weight: 231.08
MOL File: 5051-62-7.mol

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GUANABENZ Property

Melting point:: 227-229° (dec)
Boiling point:: 353.9±52.0 °C(Predicted)
Density: 1.49±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 12 mg/mL (51.93 mM);Ethanol: 15 mg/mL (64.91 mM)
pka: pKa 8.1 (Uncertain)
Water Solubility: Water: Insoluble

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22-62
Safety Statements: 22-36/37/39
RIDADR: 3249
WGK Germany: 3
HazardClass: 6.1(b)
PackingGroup: III

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P281Use personal protective equipment as required.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P322Specific measures (see …on this label).

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S762091
Product name: N-(2,6-DICHLOROBENZYLIDENEAMINO)GUANIDINE
Purity: Aldrich
Packaging: 50mg
Price: $179
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: API0006231
Product name: GUANABENZ
Purity: 95.00%
Packaging: 5MG
Price: $502.68
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 75138
Product name: Guanabenz
Packaging: 5mg
Price: $1545
Updated: 2021/12/16

CSNpharm

Product number: CSN23785
Product name: GUANABENZ
Packaging: 100mg
Price: $237
Updated: 2021/12/16

AHH

Product number: MT-08425
Product name: 1-(2,6-Dichlorobenzylideneamino)guanidine
Purity: 98%
Packaging: 0.1g
Price: $306
Updated: 2021/12/16

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GUANABENZ Chemical Properties,Usage,Production

Description

Guanabenz is an α2-adrenergic agonist that exhibits pronounced hypotensive action, and that is associated with a reduction of overall peripheral vascular resistance, decline in frequency of cardiac contractions, and reduced cardiac output.

Originator

Wytensin,Wyeth,US,1982

Uses

alpha agonists

Uses

It is used both independently and in combination with oral diuretics for treating various degrees of hypertension.

Definition

ChEBI: Guanabenz is a dichlorobenzene.

Manufacturing Process

A mixture of 14.0 g of 2,6-dichlorobenzaldehyde, 10.8 g of aminoguanidine bicarbonate and 100 ml of pyridine was refluxed for 3 hours. The reaction mixture was poured into water and the crystalline precipitate filtered off; MP 225°C to 227°C.

Therapeutic Function

Antihypertensive

Synthesis

Guanabenz, [(2,6-dichlorobenzyliden) amino] guanidine (22.3.1), is synthesized in one step by reacting 2,6-dichlorobenzaldehyde with amino guanidine.

Purification Methods

Crystallise the guanidine from MeCN and store it in a CO2–free atmosphere. The monoHCl [23256-5-0] has m 178o(dec) [solubility w% at 25o is 1.1(H2O), 5(EtOH), 0.1(EtOAc), 0.06(CHCl3)]. It is an antihypertensive drug. [Holmes et al. Drugs 26 212 1983.]

GUANABENZ Preparation Products And Raw materials

Raw materials

Preparation Products

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GUANABENZ Suppliers

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View Lastest Price from GUANABENZ manufacturers

Dideu Industries Group Limited

Product: GUANABENZ 5051-62-7
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons min
Release date: 2021-08-10

Shaanxi Dideu Medichem Co. Ltd

Product: Guanabenz 5051-62-7
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 500 MT
Release date: 2020-05-09

5051-62-7, GUANABENZRelated Search:

Guanabenz monoacetate GUANABENZ ACETATE USP(CRM STANDARD) SALOR-INT L150797-1EA GUANABENZ HYDROCHLORIDE GUANABENZ SALOR-INT L151246-1EA guanoxabenz AURORA 15157 SALOR-INT L136514-1EA guanabenz acetate salt,GUANABENZ ACETATE SALOR-INT L151203-1EA

GUANABENZ

2-[(2,6-dichlorophenyl)methylene]-hydrazinecarboximidamide

n-(2,6-dichlorobenzylidene)amino]guanidine

n-(2,6-dichlorobenzylidene)-n’-amidinohydrazine

nsc-68982

Rexitene

HydrazinecarboxiMidaMide, 2-[(2,6-dichlorophenyl)Methylene]-

1-(2,6-DICHLOROBENZYLIDENEAMINO)GUANIDINE

2-(2,6-Dichlorobenzylidene)hydrazine-1-carboximidamide

Guanabenz (WY 8678)

GUANABENZ USP/EP/BP

Callosum benzyl

GUANABENZ,inhibit,Adrenergic Receptor,high blood pressure,Beta Receptor,antiparasitic,Inhibitor,antihypertensive,Parasite

5051-62-7

C8H8Cl2N4

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