S0859

ChemicalBook > CAS DataBase List > S0859

Uses

Product Name: S0859
CAS No.: 1019331-10-2
Chemical Name: S0859
Synonyms: S0859;100852;CS-1766;NBC(S0859);S0859, >98%;S0859 >=98% (HPLC);S 0859; S-0859; S 0859; S-0859;(4S)-4-HYDROXY-4-[(3R)-3-HYDROXYBUTYL]-3,5,5-TRIMETHYL-2-CYCLOHEXEN-1-ONE;2-chloro-N-((2'-(N-cyanosulfamoyl)biphenyl-4-yl)methyl)-N-(4-methylbenzyl)benzamide;2-Chloro-N-((2'-(N-cyanosulfamoyl)-[1,1'-biphenyl]-4-yl)methyl)-N-(4-methylbenzyl)benzamide
CBNumber: CB32642793
Molecular Formula: C29H24ClN3O3S
Formula Weight: 530.04
MOL File: 1019331-10-2.mol

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S0859 Property

Boiling point:: 748.5±70.0 °C(Predicted)
Density: 1.313±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO: soluble10mg/mL, clear
form: powder
pka: -1.34±0.40(Predicted)
color: white to light brown

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0638
Product name: S0859
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $123
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0638
Product name: S0859
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $496
Updated: 2024/03/01

Cayman Chemical

Product number: 18497
Product name: S0859
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 18497
Product name: S0859
Purity: ≥95%
Packaging: 5mg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 18497
Product name: S0859
Purity: ≥95%
Packaging: 10mg
Price: $153
Updated: 2024/03/01

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S0859 Chemical Properties,Usage,Production

Uses

2-Chloro-N-[[2'-[(cyanoamino)sulfonyl][1,1'-biphenyl]-4-yl]methyl]-N-[(4-methylphenyl)methyl]benzamide is a selective inhibitor of sodium-bicarbonate cotransporters in mammalian heart.

Description

S0859 is an N-cyanosulphonamide that blocks the sodium/bicarbonate cotransporter (NBC, also known as SLC4A7), which regulates intracellular pH, particularly in myocytes. It inhibits intracellular pH recovery in myocytes with a K_i value of 1.7 μM, with full inhibition occurring at ~30 μM. S0859 does not affect other exchange proteins or enzymes that might regulate intracellular pH. It prevents changes in pH associated with depolarization and hyperpolarization of ventricular myocytes from rabbit, rat, and guinea pig. S0859 has also been used to study the role of NBC in coronary endothelial cells, cancer cells, embryonic kidney cells, and neutrophils.

Uses

2-Chloro-N-[[2''-[(cyanoamino)sulfonyl][1,1''-biphenyl]-4-yl]methyl]-N-[(4-methylphenyl)methyl]benzamide is a selective inhibitor of sodium-bicarbonate cotransporters in mammalian heart.

Biochem/physiol Actions

S0859 is a selective high-affinity generic inhibitor of the Na+/HCO3- sodium bicarbonate co-transporter (NBC). S0859 does not inhibit Na+-H+ exchange (NHE).

S0859 Preparation Products And Raw materials

Raw materials

Preparation Products

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S0859 Suppliers

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View Lastest Price from S0859 manufacturers

Zhejiang J&C Biological Technology Co.,Limited

Product: S0859 1019331-10-2
Price: US $0.00/gram
Min. Order: 1gram
Purity: 99%
Supply Ability: 10kg
Release date: 2022-02-17

Career Henan Chemical Co

Product: 1H-Isoindole-1,3(2H)-dione, 5-[5-[[3-(4-broMophenyl)-2-iMino-4-oxo-5-thiazolidinylidene]Methyl]-2-furanyl]- 1019331-10-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 20kg
Release date: 2019-09-05

1019331-10-2, S0859Related Search:

Deionized water N,N'-Ethylenebis(stearamide) (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride

2-chloro-N-[[2'-[(cyanoamino)sulfonyl][1,1'-biphenyl]-4-yl]methyl]-N-[(4-methylphenyl)methyl]- S0859

2-Chloro-N-[[2′-[(cyanoamino)sulfonyl][1,1′-biphenyl]-4-yl]methyl]-N-[(4-methylphenyl)methyl]-benzamide

2-Chloro-N-((2'-(N-cyanosulfamoyl)-[1,1'-biphenyl]-4-yl)methyl)-N-(4-methylbenzyl)benzamide

S0859

(4S)-4-HYDROXY-4-[(3R)-3-HYDROXYBUTYL]-3,5,5-TRIMETHYL-2-CYCLOHEXEN-1-ONE

100852

S 0859; S-0859; S 0859; S-0859

CS-1766

S0859, >98%

Benzamide, 2-chloro-N-[[2'-[(cyanoamino)sulfonyl][1,1'-biphenyl]-4-yl]methyl]-N-[(4-methylphenyl)methyl]-

S0859 >=98% (HPLC)

2-Chloro-N-({4-[2-(cyanosulfamoyl)phenyl]phenyl}methyl)-N-[(4-methylphenyl)methyl]benzamide

NBC(S0859)

2-chloro-N-((2'-(N-cyanosulfamoyl)biphenyl-4-yl)methyl)-N-(4-methylbenzyl)benzamide

2-Chloro-N-((2'-(N-cyanosulfamoyl)-[1,1'-biphenyl]-4-yl)methyl)-N-(4-methylbenzyl)benzamide

1019331-10-2

Inhibitors

APIs