2,6-Dichloro-3,5-dimethoxyaniline
- Product Name
- 2,6-Dichloro-3,5-dimethoxyaniline
- CAS No.
- 872509-56-3
- Chemical Name
- 2,6-Dichloro-3,5-dimethoxyaniline
- Synonyms
- 157427;oro-3,5-dimethoxyaniL;2,6-Dichloro-3,5-dimethoxyaniline;2,6-Dichloro-3,5-dimethoxybenzenamine;2,6-Dichloro-3,5-dimethoxy-phenylamine;Benzenamine, 2,6-dichloro-3,5-dimethoxy-
- CBNumber
- CB32651401
- Molecular Formula
- C8H9Cl2NO2
- Formula Weight
- 222.07
- MOL File
- 872509-56-3.mol
2,6-Dichloro-3,5-dimethoxyaniline Property
- Boiling point:
- 320℃
- Density
- 1.357
- Flash point:
- 147℃
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- -0.13±0.10(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C8H9Cl2NO2/c1-12-4-3-5(13-2)7(10)8(11)6(4)9/h3H,11H2,1-2H3
- InChIKey
- LCQFHEIDCMPNAN-UHFFFAOYSA-N
- SMILES
- C1(N)=C(Cl)C(OC)=CC(OC)=C1Cl
Safety
- HS Code
- 2922299090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D439900
- Product name
- 2,6-Dichloro-3,5-dimethoxyaniline
- Packaging
- 1g
- Price
- $350
- Updated
- 2021/12/16
- Product number
- X6587
- Product name
- 2,6-Dichloro-3,5-dimethoxyaniline
- Packaging
- 10g
- Price
- $951
- Updated
- 2021/12/16
- Product number
- CD12021343
- Product name
- 2,6-Dichloro-3,5-dimethoxyaniline
- Purity
- 98%
- Packaging
- 10g
- Price
- $960
- Updated
- 2021/12/16
- Product number
- 872509563
- Product name
- 2,6-Dichloro-3,5-dimethoxyaniline
- Packaging
- 10g
- Price
- $988.8
- Updated
- 2021/12/16
- Product number
- A221478
- Product name
- 2,6-Dichloro-3,5-dimethoxyaniline
- Purity
- 98%
- Packaging
- 25g
- Price
- $1372
- Updated
- 2021/12/16
2,6-Dichloro-3,5-dimethoxyaniline Chemical Properties,Usage,Production
Chemical Properties
White to off-white powder
Uses
2,6-Dichloro-3,5-dimethoxyaniline is primarily used as an intermediate in the synthesis of pharmaceuticals.
Synthesis
943189-21-7
872509-56-3
N-(2,6-dichloro-3,5-dimethoxyphenyl)acetamide (34.5 g, 131 mmol) was used as a raw material and dissolved in ethanol (600 mL). Subsequently, 2N aqueous potassium hydroxide solution (400 mL) was added to this solution to obtain the reaction mixture. The reaction mixture was heated to 90°C and stirred, and the reaction was kept at reflux for 2 days. Upon completion of the reaction, the mixture was cooled to room temperature, then cooled to 0 °C in an ice water bath and stirring was continued for 1 hour. The precipitated solid was collected by filtration, washed with cold ethanol/water (1:1, v/v) mixed solvent and dried to give 2,6-dichloro-3,5-dimethoxyaniline (22.1 g, 76% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d5): δ 6.21 (s, 1H), 5.40 (s, 2H), 3.83 (s, 6H).
References
[1] Journal of Medicinal Chemistry, 2011, vol. 54, # 20, p. 7066 - 7083
[2] Patent: US2016/145240, 2016, A1. Location in patent: Paragraph 0098; 0099
[3] Patent: WO2016/164703, 2016, A1. Location in patent: Page/Page column 36
[4] Patent: WO2016/164754, 2016, A1. Location in patent: Page/Page column 33
[5] Patent: WO2006/420, 2006, A1. Location in patent: Page/Page column 157
2,6-Dichloro-3,5-dimethoxyaniline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,6-Dichloro-3,5-dimethoxyaniline manufacturers
- Product
- 2,6-dichloro-3,5-dimethoxyaniline 872509-56-3
- Price
- US $0.00/kg
- Min. Order
- 20kg
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2025-04-14
- Product
- 2,6-Dichloro-3,5-dimethoxyaniline 872509-56-3
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2020-04-27
- Product
- 2,6-dichloro-3,5-dimethoxyaniline 872509-56-3
- Price
- US $0.00-0.00/KG
- Min. Order
- 100g
- Purity
- 99.0%+
- Supply Ability
- 100 tons
- Release date
- 2020-01-16