360 A iodide

Product Name: 360 A iodide
CAS No.: 737763-37-0
Chemical Name: 360 A iodide
Synonyms: 360 A iodide;360A (iodide);3,3'-[2,6-Pyridinediylbis(carbonylimino)]bis[1-methylquinolinium] diiodide
CBNumber: CB32666580
Molecular Formula: C27H23IN5O2+
Formula Weight: 576.42
MOL File: 737763-37-0.mol

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360 A iodide Property

storage temp.: Store at -20°C
solubility: insoluble in H2O; insoluble in EtOH; insoluble in DMSO
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology

Product number: A3120
Product name: 360Aiodide
Packaging: 5mg
Price: $230
Updated: 2021/12/16

ChemScene

Product number: CS-1560
Product name: 360Aiodide
Purity: ≥98.0%
Packaging: 5mg
Price: $240
Updated: 2021/12/16

ApexBio Technology

Product number: A3120
Product name: 360Aiodide
Packaging: 10mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-1560
Product name: 360Aiodide
Purity: ≥98.0%
Packaging: 10mg
Price: $384
Updated: 2021/12/16

ApexBio Technology

Product number: A3120
Product name: 360Aiodide
Packaging: 25mg
Price: $650
Updated: 2021/12/16

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360 A iodide Chemical Properties,Usage,Production

Uses

360A iodide is a selective stabilizer of G-quadruplex, and also inhibits telomerase activity with an IC50 of 300 nM for telomerase in TRAP-G4 assay.

Biological Activity

360a is a 2,6-pyridine-dicarboxamide derivative displaying strong affinity and selectivity for g-quadruplex structures and selective telomerase inhibition in vitro assays. 360a is a g-quadruplex ligand, which can influence the consequence of g-quadruplex formation and/or stabilization.

in vitro

we found a s-phase accumulation in atm-proficient, but not in atm-deficient ebv-lymphocytes treated with 360a before induction of cell death. however, atm status did not modify cell cycle distribution in 360a-treated sv40-fibroblasts and hela cells compared to dmso treated controls [1]. dna-pkcs-dependent nhej was responsible for sister telomere fusions as a direct consequence of g-quadruplex formation and/or stabilization induced by 360a on parental telomere g strands. nhej and hr activation at telomeres altered mitotic progression in treated cells [2]. this compound was shown to display a potent affinity and selectivity for telomeric g-quadruplex dna over duplex dna and to induce delayed growth inhibition in ht1080 tumor cell line [3].

References

[1] Pennarun G, et al. Apoptosis related to telomere instability and cell cycle alterations in human glioma cells treated by new highly selective G-quadruplex ligands. Oncogene. 2005 Apr 21;24(18):2917-28. DOI:10.1038/sj.onc.1208468
[2] Gauthier LR, et al. Rad51 and DNA-PKcs are involved in the generation of specific telomere aberrations induced by the quadruplex ligand 360A that impair mitotic cell progression and lead to cell death. Cell Mol Life Sci. 2012 Feb;69(4):629-40. DOI:10.1007/s00018-011-0767-6

360 A iodide Preparation Products And Raw materials

Raw materials

Preparation Products

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360 A iodide Suppliers

China 37 United States 10 Global 47

Chembest Research Laboratories Limited

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737763-37-0, 360 A iodideRelated Search:

MPP+ IODIDE DiR iodide [1,1‘-dioctadecyl-3,3,3',3‘-tetramethylindotricarbocyanine iodide] 5-(Acetamido)-N,N'-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide

360 A iodide

360A (iodide)

3,3'-[2,6-Pyridinediylbis(carbonylimino)]bis[1-methylquinolinium] diiodide

737763-37-0

C27H23I2N5O2

C27H23N5O22I