360 A iodide
- Product Name
- 360 A iodide
- CAS No.
- 737763-37-0
- Chemical Name
- 360 A iodide
- Synonyms
- 360 A iodide;360A (iodide);3,3'-[2,6-Pyridinediylbis(carbonylimino)]bis[1-methylquinolinium] diiodide
- CBNumber
- CB32666580
- Molecular Formula
- C27H23IN5O2+
- Formula Weight
- 576.42
- MOL File
- 737763-37-0.mol
360 A iodide Property
- storage temp.
- Store at -20°C
- solubility
- insoluble in H2O; insoluble in EtOH; insoluble in DMSO
N-Bromosuccinimide Price
- Product number
- A3120
- Product name
- 360Aiodide
- Packaging
- 5mg
- Price
- $230
- Updated
- 2021/12/16
- Product number
- CS-1560
- Product name
- 360Aiodide
- Purity
- ≥98.0%
- Packaging
- 5mg
- Price
- $240
- Updated
- 2021/12/16
- Product number
- A3120
- Product name
- 360Aiodide
- Packaging
- 10mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- CS-1560
- Product name
- 360Aiodide
- Purity
- ≥98.0%
- Packaging
- 10mg
- Price
- $384
- Updated
- 2021/12/16
- Product number
- A3120
- Product name
- 360Aiodide
- Packaging
- 25mg
- Price
- $650
- Updated
- 2021/12/16
360 A iodide Chemical Properties,Usage,Production
Biological Activity
360a is a 2,6-pyridine-dicarboxamide derivative displaying strong affinity and selectivity for g-quadruplex structures and selective telomerase inhibition in vitro assays. 360a is a g-quadruplex ligand, which can influence the consequence of g-quadruplex formation and/or stabilization.
in vitro
we found a s-phase accumulation in atm-proficient, but not in atm-deficient ebv-lymphocytes treated with 360a before induction of cell death. however, atm status did not modify cell cycle distribution in 360a-treated sv40-fibroblasts and hela cells compared to dmso treated controls [1]. dna-pkcs-dependent nhej was responsible for sister telomere fusions as a direct consequence of g-quadruplex formation and/or stabilization induced by 360a on parental telomere g strands. nhej and hr activation at telomeres altered mitotic progression in treated cells [2]. this compound was shown to display a potent affinity and selectivity for telomeric g-quadruplex dna over duplex dna and to induce delayed growth inhibition in ht1080 tumor cell line [3].
360 A iodide Preparation Products And Raw materials
Raw materials
Preparation Products
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