RG-7388

ChemicalBook > CAS DataBase List > RG-7388

Product Name: RG-7388
CAS No.: 1229705-06-9
Chemical Name: RG-7388
Synonyms: Idasanutlin;RG7388;Pexidartinib Hydrochloride;RG-7388;RG 7388;Ro 5503781;RG-7388 USP/EP/BP;RG-7388, Idasanutlin;Idasanutlin (RG-7388);RG 7388; RG-7388; RG7388
CBNumber: CB32666681
Molecular Formula: C31H29Cl2F2N3O4
Formula Weight: 616.48
MOL File: 1229705-06-9.mol

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RG-7388 Property

Melting point:: >261° (dec.)
Boiling point:: 737.3±60.0 °C(Predicted)
Density: 1.40±0.1 g/cm3(Predicted)
storage temp.: -20°C Freezer
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 4.11±0.10(Predicted)
form: Solid
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21532
Product name: RG7388
Purity: ≥98%
Packaging: 1mg
Price: $47
Updated: 2024/03/01

Cayman Chemical

Product number: 21532
Product name: RG7388
Purity: ≥98%
Packaging: 5mg
Price: $206
Updated: 2024/03/01

Cayman Chemical

Product number: 21532
Product name: RG7388
Purity: ≥98%
Packaging: 10mg
Price: $339
Updated: 2024/03/01

Cayman Chemical

Product number: 21532
Product name: RG7388
Purity: ≥98%
Packaging: 25mg
Price: $564
Updated: 2024/03/01

Tocris

Product number: 6904
Product name: Idasanutlin
Purity: ≥98%(HPLC)
Packaging: 50
Price: $609
Updated: 2021/12/16

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RG-7388 Chemical Properties,Usage,Production

Description

Potent MDM2 inhibitor with an IC50 = 6 nM in binding assay and 30 nM in cancer cell proliferation assay. Induces p53 stabilisation, cell cycle arrest and apoptosis in cancer cells expression wildtype p53. Displays inhibition of tumor growth in the SJSA1 tumor xenograft model. Also inhibits MDR-1 at high concentrations.

Uses

Idasanutlin is an MDM2 inihibtor, blocking the p53 protein-protein interaction and may be used in anti-cancer treatments.

storage

Store at -20°C

RG-7388 Preparation Products And Raw materials

Raw materials

Preparation Products

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RG-7388 Suppliers

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View Lastest Price from RG-7388 manufacturers

Career Henan Chemical Co

Product: RG-7388 1229705-06-9
Price: US $2.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100g , 1kg, 5kg , 50kg
Release date: 2020-01-07

1229705-06-9, RG-7388Related Search:

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Idasanutlin

4-[[[(2R,3S,4R,5S)-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-2-pyrrolidinyl]carbonyl]amino]-3-methoxybenzoic acid

RG 7388

RG7388

RG-7388

RG-7388, Idasanutlin

Idasanutlin (RG-7388)

RG 7388; RG-7388; RG7388

Pexidartinib Hydrochloride

4-[[(2R,3S,4R,5S)-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimet

4-{[(2R,3S,4R,5S)-4-(4-Chloro-2-fluoro-phenyl)-3-(3-chloro-2-fluoro-phenyl)-4-cyano-5-(2,2-dimethyl-propyl)-pyrrolidine-2-carbonyl]-amino}-3-methoxy-benzoic acid

Ro 5503781

Benzoic acid, 4-[[[(2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-2-pyrrolidinyl]carbonyl]amino]-3-methoxy-

4-{[(3s,4r,5s)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-D-prolyl]amino}-3-methoxybenzoic acid

RG-7388 USP/EP/BP

4-[(2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-(2,2-dimethylpropyl)pyrrolidine-2-amido]-3-methoxybenzoic acid

4-((2R,3S,4R,5S)-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-neopentylpyrrolidine-2-carboxamido)-3-methoxybenzoic acid

4-{(3S,4R,5S)-3-(3-Chloro-2-fluorophenyl)-4-(2-fluoro-4-chlorophenyl)-4-cyano-5-(2,2-dimethylpropyl)-D-prolylamino}-3-methoxy-benzoic acid

1229705-06-9

C31H29Cl2F2N3O4

Inhibitors