MK 6096
- Product Name
- MK 6096
- CAS No.
- 1088991-73-4
- Chemical Name
- MK 6096
- Synonyms
- MK6096;MK-6096;CS-1825;MK 6096;Filorexant;MK 6096;MK6096;MK-6096(Filorexant);Filorexant(MK-6096);Filorexant, 10 mM in DMSO;filorexant / MK-6096, CID25128145
- CBNumber
- CB32666757
- Molecular Formula
- C24H25FN4O2
- Formula Weight
- 420.48
- MOL File
- 1088991-73-4.mol
MK 6096 Property
- Boiling point:
- 540.2±50.0 °C(Predicted)
- Density
- 1.203±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMF: 10mg/mL; DMF:PBS (pH 7.2) (1:4): 0.2mg/mL; DMSO: 2mg/mL; Ethanol: 5mg/mL
- form
- A solid
- pka
- 1.54±0.22(Predicted)
- color
- Off-white to brown
N-Bromosuccinimide Price
- Product number
- 29490
- Product name
- Filorexant
- Packaging
- 25mg
- Price
- $421
- Updated
- 2024/03/01
- Product number
- 29490
- Product name
- Filorexant
- Packaging
- 50mg
- Price
- $629
- Updated
- 2024/03/01
- Product number
- 29490
- Product name
- Filorexant
- Packaging
- 5mg
- Price
- $141
- Updated
- 2024/03/01
- Product number
- 29490
- Product name
- Filorexant
- Packaging
- 10mg
- Price
- $253
- Updated
- 2024/03/01
- Product number
- F337008
- Product name
- Filorexant
- Packaging
- 5mg
- Price
- $140
- Updated
- 2021/12/16
MK 6096 Chemical Properties,Usage,Production
Description
Filorexant is a dual antagonist of orexin 1 receptor (OX1R) and OX2R (Kis = 2.5 and 0.31 nM, respectively, for the recombinant human receptors). It selectively inhibits OX1R and OX2R over a panel of more than 170 receptors and enzymes. Filorexant inhibits orexin A-induced calcium mobilization in CHO cells expressing recombinant human OX1R or OX2R (Kb = 11 nM for both). It decreases locomotor activity in rats during the dark cycle when administered at a dose of 10 mg/kg. Filorexant (0.5 mg/kg) reduces the time spent awake and decreases the latency to slow-wave sleep stage 1 (SWS1) and SWS2, but not rapid eye movement (REM) sleep, in dogs. It increases the duration of SWS2, but not SWS1 or REM sleep, in the same model.
Uses
Filorexant is a selective dual orexin receptor antagonist with potent sleep-promoting properties. It has advanced into phase II clinical trials for the treatment of insomnia.
in vivo
Filorexant (MK-6096) dose-dependently reduced locomotor activity and significantly increased sleep in rats (3-30 mg/kg) and dogs (0.25 and 0.5 mg/kg).
References
[1] CHRISTOPHER J. WINROW . Pharmacological characterization of MK-6096 – A dual orexin receptor antagonist for insomnia[J]. Neuropharmacology, 2012, 62 2: Pages 978-987. DOI: 10.1016/j.neuropharm.2011.10.003
MK 6096 Preparation Products And Raw materials
Raw materials
Preparation Products
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