TMC-647055
- Product Name
- TMC-647055
- CAS No.
- 1204416-97-6
- Chemical Name
- TMC-647055
- Synonyms
- CS-1838;MTC647055;TMC647055;TMC 647055;TMC-647055;11BD024G7J;CHEMBL2043025;AGN-PC-078RUU;SureCN1239667;TMC647055; AGN-PC-078RUU; SURECN1239667; CHEMBL2043025; 11BD024G7J; TMC 647055
- CBNumber
- CB32667446
- Molecular Formula
- C32H38N4O6S
- Formula Weight
- 606.73
- MOL File
- 1204416-97-6.mol
TMC-647055 Property
- Density
- 1.38±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- insoluble in H2O; insoluble in EtOH; ≥72.8 mg/mL in DMSO with gentle warming
- form
- solid
- pka
- 5.14±0.20(Predicted)
N-Bromosuccinimide Price
- Product number
- B5822
- Product name
- TMC647055Cholinesalt
- Packaging
- 5mg
- Price
- $300
- Updated
- 2021/12/16
- Product number
- B5822
- Product name
- TMC647055Cholinesalt
- Packaging
- 25mg
- Price
- $900
- Updated
- 2021/12/16
- Product number
- DC7872
- Product name
- TMC647055
- Purity
- >98%
- Packaging
- 100mg
- Price
- $1000
- Updated
- 2021/12/16
- Product number
- DC7872
- Product name
- TMC647055
- Purity
- >98%
- Packaging
- 250mg
- Price
- $1800
- Updated
- 2021/12/16
- Product number
- DC7872
- Product name
- TMC647055
- Purity
- >98%
- Packaging
- 1g
- Price
- $3600
- Updated
- 2021/12/16
TMC-647055 Chemical Properties,Usage,Production
Biological Activity
tmc647055 is a potent and selective non-nucleoside inhibitor of the hepatitis c virus ns5b polymerase with ec50 value of 82 nm [1].hepatitis c virus (hcv) ns5b polymerase is a rna-dependant rna-polymerase that is responsible for viral replication and plays an important role in hcv life cycle. hcv is a major cause of chronic liver disease and acute hepatitis, ultimately leading to liver failure, cirrhosis and hepatocellular carcinoma [1].tmc647055 is a selective and cell-permeating hcv ns5b inhibitor. in rna polymerase primer-dependent transcription assay, tmc647055 inhibited hcv ns5b polymerase with ic50 value of 34 nm. in the huh7-luc cell line, tmc647055 inhibited the replication of genotype 1b replicon with ec50 values of 77 and 139 nm measured with luciferase readout and qrt-pcr readout, respectively. tmc647055 exhibited high-affinity interaction with ns5b across all genotypes (except for genotype 2b) with median kd value < 35 nm. in huh7-luc replicon cells, tmc647055 (750 nm) reduced 30 cell colonies formation. also, tmc647055 (1.5 μm and 3.75 μm) reduced hcv replicon rna [2] [3].
References
[1]. vendeville s, lin ti, hu l, et al. finger loop inhibitors of the hcv ns5b polymerase. part ii. optimization of tetracyclic indole-based macrocycle leading to the discovery of tmc647055. bioorg med chem lett, 2012, 22(13): 4437-4443.
[2]. devogelaere b, berke jm, vijgen l, et al. tmc647055, a potent nonnucleoside hepatitis c virus ns5b polymerase inhibitor with cross-genotypic coverage. antimicrob agents chemother, 2012, 56(9): 4676-4684.
[3]. cummings md, lin ti, hu l, et al. discovery and early development of tmc647055, a non-nucleoside inhibitor of the hepatitis c virus ns5b polymerase. j med chem, 2014, 57(5): 1880-1892.
TMC-647055 Preparation Products And Raw materials
Raw materials
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