ChemicalBook > CAS DataBase List > TMC-647055

TMC-647055

Product Name
TMC-647055
CAS No.
1204416-97-6
Chemical Name
TMC-647055
Synonyms
CS-1838;MTC647055;TMC647055;TMC 647055;TMC-647055;11BD024G7J;CHEMBL2043025;AGN-PC-078RUU;SureCN1239667;TMC647055; AGN-PC-078RUU; SURECN1239667; CHEMBL2043025; 11BD024G7J; TMC 647055
CBNumber
CB32667446
Molecular Formula
C32H38N4O6S
Formula Weight
606.73
MOL File
1204416-97-6.mol
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TMC-647055 Property

Density 
1.38±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
insoluble in H2O; insoluble in EtOH; ≥72.8 mg/mL in DMSO with gentle warming
form 
solid
pka
5.14±0.20(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology
Product number
B5822
Product name
TMC647055Cholinesalt
Packaging
5mg
Price
$300
Updated
2021/12/16
ApexBio Technology
Product number
B5822
Product name
TMC647055Cholinesalt
Packaging
25mg
Price
$900
Updated
2021/12/16
DC Chemicals
Product number
DC7872
Product name
TMC647055
Purity
>98%
Packaging
100mg
Price
$1000
Updated
2021/12/16
DC Chemicals
Product number
DC7872
Product name
TMC647055
Purity
>98%
Packaging
250mg
Price
$1800
Updated
2021/12/16
DC Chemicals
Product number
DC7872
Product name
TMC647055
Purity
>98%
Packaging
1g
Price
$3600
Updated
2021/12/16
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TMC-647055 Chemical Properties,Usage,Production

Biological Activity

tmc647055 is a potent and selective non-nucleoside inhibitor of the hepatitis c virus ns5b polymerase with ec50 value of 82 nm [1].hepatitis c virus (hcv) ns5b polymerase is a rna-dependant rna-polymerase that is responsible for viral replication and plays an important role in hcv life cycle. hcv is a major cause of chronic liver disease and acute hepatitis, ultimately leading to liver failure, cirrhosis and hepatocellular carcinoma [1].tmc647055 is a selective and cell-permeating hcv ns5b inhibitor. in rna polymerase primer-dependent transcription assay, tmc647055 inhibited hcv ns5b polymerase with ic50 value of 34 nm. in the huh7-luc cell line, tmc647055 inhibited the replication of genotype 1b replicon with ec50 values of 77 and 139 nm measured with luciferase readout and qrt-pcr readout, respectively. tmc647055 exhibited high-affinity interaction with ns5b across all genotypes (except for genotype 2b) with median kd value < 35 nm. in huh7-luc replicon cells, tmc647055 (750 nm) reduced 30 cell colonies formation. also, tmc647055 (1.5 μm and 3.75 μm) reduced hcv replicon rna [2] [3].

References

[1]. vendeville s, lin ti, hu l, et al. finger loop inhibitors of the hcv ns5b polymerase. part ii. optimization of tetracyclic indole-based macrocycle leading to the discovery of tmc647055. bioorg med chem lett, 2012, 22(13): 4437-4443.
[2]. devogelaere b, berke jm, vijgen l, et al. tmc647055, a potent nonnucleoside hepatitis c virus ns5b polymerase inhibitor with cross-genotypic coverage. antimicrob agents chemother, 2012, 56(9): 4676-4684.
[3]. cummings md, lin ti, hu l, et al. discovery and early development of tmc647055, a non-nucleoside inhibitor of the hepatitis c virus ns5b polymerase. j med chem, 2014, 57(5): 1880-1892.

TMC-647055 Preparation Products And Raw materials

Raw materials

Preparation Products

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TMC-647055 Suppliers

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1204416-97-6, TMC-647055Related Search:


  • TMC 647055
  • TMC647055
  • TMC-647055
  • 2,19-methano-3,7:4,1-dimetheno-1H,11H-14,10,2,9,11,17-benzoxathiatetraazacyclodocosine-8,18(9H,15H)-dione
  • 27-Cyclohexyl-12,13,16,17-tetrahydro-22-methoxy-11,17-dimethyl-2,19-methano-3,7:4,1-dimetheno-1H,11H-14,10,2,9,11,17-benzoxathiatetraazacyclodocosine-8,18(9H,15H)-dione 10,10-dioxide
  • MTC647055
  • CS-1838
  • TMC647055; AGN-PC-078RUU; SURECN1239667; CHEMBL2043025; 11BD024G7J; TMC 647055
  • 11BD024G7J
  • AGN-PC-078RUU
  • CHEMBL2043025
  • SureCN1239667
  • 2,19-Methano-3,7:4,1-dimetheno-1H,11H-14,10,2,9,11,17-benzoxathiatetraazacyclodocosine-8,18(9H,15H)-dione, 27-cyclohexyl-12,13,16,17-tetrahydro-22-methoxy-11,17-dimethyl-, 10,10-dioxide
  • 1204416-97-6
  • C32H38N4O6S
  • C37H53N5O8S