TMC-647055

Product Name: TMC-647055
CAS No.: 1204416-97-6
Chemical Name: TMC-647055
Synonyms: CS-1838;MTC647055;TMC647055;TMC 647055;TMC-647055;11BD024G7J;CHEMBL2043025;AGN-PC-078RUU;SureCN1239667;TMC647055; AGN-PC-078RUU; SURECN1239667; CHEMBL2043025; 11BD024G7J; TMC 647055
CBNumber: CB32667446
Molecular Formula: C32H38N4O6S
Formula Weight: 606.73
MOL File: 1204416-97-6.mol

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TMC-647055 Property

Density: 1.38±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in H2O; insoluble in EtOH; ≥72.8 mg/mL in DMSO with gentle warming
form: solid
pka: 5.14±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ApexBio Technology

Product number: B5822
Product name: TMC647055Cholinesalt
Packaging: 5mg
Price: $300
Updated: 2021/12/16

ApexBio Technology

Product number: B5822
Product name: TMC647055Cholinesalt
Packaging: 25mg
Price: $900
Updated: 2021/12/16

DC Chemicals

Product number: DC7872
Product name: TMC647055
Purity: >98%
Packaging: 100mg
Price: $1000
Updated: 2021/12/16

DC Chemicals

Product number: DC7872
Product name: TMC647055
Purity: >98%
Packaging: 250mg
Price: $1800
Updated: 2021/12/16

DC Chemicals

Product number: DC7872
Product name: TMC647055
Purity: >98%
Packaging: 1g
Price: $3600
Updated: 2021/12/16

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TMC-647055 Chemical Properties,Usage,Production

Biological Activity

tmc647055 is a potent and selective non-nucleoside inhibitor of the hepatitis c virus ns5b polymerase with ec50 value of 82 nm [1].hepatitis c virus (hcv) ns5b polymerase is a rna-dependant rna-polymerase that is responsible for viral replication and plays an important role in hcv life cycle. hcv is a major cause of chronic liver disease and acute hepatitis, ultimately leading to liver failure, cirrhosis and hepatocellular carcinoma [1].tmc647055 is a selective and cell-permeating hcv ns5b inhibitor. in rna polymerase primer-dependent transcription assay, tmc647055 inhibited hcv ns5b polymerase with ic50 value of 34 nm. in the huh7-luc cell line, tmc647055 inhibited the replication of genotype 1b replicon with ec50 values of 77 and 139 nm measured with luciferase readout and qrt-pcr readout, respectively. tmc647055 exhibited high-affinity interaction with ns5b across all genotypes (except for genotype 2b) with median kd value < 35 nm. in huh7-luc replicon cells, tmc647055 (750 nm) reduced 30 cell colonies formation. also, tmc647055 (1.5 μm and 3.75 μm) reduced hcv replicon rna [2] [3].

References

[1]. vendeville s, lin ti, hu l, et al. finger loop inhibitors of the hcv ns5b polymerase. part ii. optimization of tetracyclic indole-based macrocycle leading to the discovery of tmc647055. bioorg med chem lett, 2012, 22(13): 4437-4443.
[2]. devogelaere b, berke jm, vijgen l, et al. tmc647055, a potent nonnucleoside hepatitis c virus ns5b polymerase inhibitor with cross-genotypic coverage. antimicrob agents chemother, 2012, 56(9): 4676-4684.
[3]. cummings md, lin ti, hu l, et al. discovery and early development of tmc647055, a non-nucleoside inhibitor of the hepatitis c virus ns5b polymerase. j med chem, 2014, 57(5): 1880-1892.

TMC-647055 Preparation Products And Raw materials

Raw materials

Preparation Products

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TMC-647055 Suppliers

China 39 United States 3 Global 42

Shanghai Boyle Chemical Co., Ltd.

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Sichuan Wei Keqi Biological Technology Co., Ltd.

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LETOPHARM LIMITED

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Shanghai Lollane Biological Technology Co.,Ltd.

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Shanghaizehan biopharma technology co., Ltd.

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Hui Chem Co., Ltd.

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SPIRO PHARMA

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Shanghai Chiral bio-compound co., Ltd.

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Lanzhou Angeli Biochemical Technology Co., Ltd.

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Shanghai QianYan Bio-technology Co., Ltd

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1204416-97-6, TMC-647055Related Search:

TMC 647055

TMC647055

TMC-647055

2,19-methano-3,7:4,1-dimetheno-1H,11H-14,10,2,9,11,17-benzoxathiatetraazacyclodocosine-8,18(9H,15H)-dione

27-Cyclohexyl-12,13,16,17-tetrahydro-22-methoxy-11,17-dimethyl-2,19-methano-3,7:4,1-dimetheno-1H,11H-14,10,2,9,11,17-benzoxathiatetraazacyclodocosine-8,18(9H,15H)-dione 10,10-dioxide

MTC647055

CS-1838

TMC647055; AGN-PC-078RUU; SURECN1239667; CHEMBL2043025; 11BD024G7J; TMC 647055

11BD024G7J

AGN-PC-078RUU

CHEMBL2043025

SureCN1239667

2,19-Methano-3,7:4,1-dimetheno-1H,11H-14,10,2,9,11,17-benzoxathiatetraazacyclodocosine-8,18(9H,15H)-dione, 27-cyclohexyl-12,13,16,17-tetrahydro-22-methoxy-11,17-dimethyl-, 10,10-dioxide

1204416-97-6

C32H38N4O6S

C37H53N5O8S