S1RA
- Product Name
- S1RA
- CAS No.
- 878141-96-9
- Chemical Name
- S1RA
- Synonyms
- S1RA;E52862;CS-1020;S1RA, >=98%;S1RA(E-52862);S1RA, 878141-96-9;E-52862; E52862; E 52862;4-(2-{[5-Methyl-1-(2-naphthyl)-1H-pyrazol-3-yl]oxy}ethyl)morpholi ne;4-(2-{[5-Methyl-1-(naphthalen-2-yl)pyrazol-3-yl]oxy}ethyl)morpholine;4-[2-[[5-Methyl-1-(2-naphthalenyl)-1H-pyrazol-3-yl]oxy]ethyl]morpholine
- CBNumber
- CB32667552
- Molecular Formula
- C20H23N3O2
- Formula Weight
- 337.42
- MOL File
- 878141-96-9.mol
S1RA Property
- Boiling point:
- 528.1±50.0 °C(Predicted)
- Density
- 1.21±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≥10.35 mg/mL in DMSO; ≥12.23 mg/mL in EtOH; ≥56.1 mg/mL in H2O
- form
- solid
- pka
- 6.15±0.10(Predicted)
- color
- Off-white to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 16279
- Product name
- S1RA
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- 16279
- Product name
- S1RA
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $152
- Updated
- 2024/03/01
- Product number
- 16279
- Product name
- S1RA
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $435
- Updated
- 2024/03/01
- Product number
- 16279
- Product name
- S1RA
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $711
- Updated
- 2024/03/01
- Product number
- orb181123
- Product name
- S1RA
- Purity
- >98%
- Packaging
- 100mg
- Price
- $765
- Updated
- 2021/12/16
S1RA Chemical Properties,Usage,Production
Biological Activity
s1ra is a potent and selective antagonist of σ1 receptor (σ1r) with ki value of 17nm [1].s1ra is the first σ1 receptor antagonist with potent antinociceptive activities in various pain models. in the binding assay, s1ra shows good affinity to human σ1 receptor transfected in hek293 membranes with ki value of 17nm. the ki value for guinea pig brain membrane σ1 receptor is higher than 1μm. s1ra also shows no significant affinity to another 170 molecular targets including receptors, ion channels and enzymes [1, 2].in the mouse tests, s1ra exhibits potent analgesic effects on capsaicin-induced mechanical hypersensitivity and formalin-induced pain. besides that, s1ra inhibits both mechanical allodynia and thermal hypersensitivity with ed50 values of 23.4mg/kg and 18.8mg/kg in the partial sciatic nerve ligation model in mice [1].
References
[1] díaz j l, cuberes r, berrocal j, et al. synthesis and biological evaluation of the 1-arylpyrazole class of σ1 receptor antagonists: identification of 4-{2-[5-methyl-1-(naphthalen-2-yl)-1 h-pyrazol-3-yloxy] ethyl} morpholine (s1ra, e-52862). journal of medicinal chemistry, 2012, 55(19): 8211-8224.
[2] wunsch b. the σ1 receptor antagonist s1ra is a promising candidate for the treatment of neurogenic painj. journal of medicinal chemistry, 2012, 55(19): 8209-8210.
S1RA Preparation Products And Raw materials
Raw materials
Preparation Products
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