R 112 (pharMaceutical)

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R 112 (pharMaceutical)

Product Name: R 112 (pharMaceutical)
CAS No.: 575474-82-7
Chemical Name: R 112 (pharMaceutical)
Synonyms: R112, >98%;R-112; R 112;(E)-Elafibranor;R 112 (pharMaceutical);3,3'-[(5-Fluoro-2,4-pyrimidinediyl)diimino]diphenol;Phenol, 3,3'-[(5-fluoro-2,4-pyrimidinediyl)diimino]bis-;3,3'-((5-Fluoropyrimidine-2,4-diyl)bis(azanediyl))diphenol;Spleen tyrosine kinase,allergic rhinitis,R112,fast,tryptase,Inhibitor,R 112,phosphorylation,IL-8,GM-CSF,histamine,LTC4,reversible,basophil,R-112,TNF-α,Syk,inhibit
CBNumber: CB32667633
Molecular Formula: C16H13FN4O2
Formula Weight: 312.3
MOL File: 575474-82-7.mol

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R 112 (pharMaceutical) Property

Boiling point:: 552.0±60.0 °C(Predicted)
Density: 1.494±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:30.0(Max Conc. mg/mL);96.1(Max Conc. mM)
form: A crystalline solid
pka: 9.48±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22929
Product name: R112
Packaging: 1mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 22929
Product name: R112
Packaging: 5mg
Price: $356
Updated: 2024/03/01

Cayman Chemical

Product number: 22929
Product name: R112
Packaging: 10mg
Price: $593
Updated: 2024/03/01

Cayman Chemical

Product number: 22929
Product name: R112
Packaging: 25mg
Price: $1184
Updated: 2024/03/01

TRC

Product number: R060010
Product name: R112
Packaging: 5mg
Price: $360
Updated: 2021/12/16

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R 112 (pharMaceutical) Chemical Properties,Usage,Production

Description

R112 is an inhibitor of spleen tyrosine kinase (Syk; IC₅₀ = 226 nM in cultured human mast cells) that acts in an ATP-competitive and reversible manner (K_i = 96 nM). It inhibits mast cell and basophil degranulation induced by anti-IgE cross-linking (EC₅₀s = 353 and 280 nM, respectively). It also inhibits basophil degranulation induced by an allergen with an EC₅₀ value of 490 nM. R112 inhibits the production of leukotriene C₄ (LTC₄; ) and decreases cytokine levels in cultured human mast cells.

Uses

R 112 is Syk inhibitor. It can be used in biological study and therapeutic use of application of cultured human mast cells (CHMC) for design and structure-activity relationship of IgE-mediated mast cell activation inhibitors.

R 112 (pharMaceutical) Preparation Products And Raw materials

Raw materials

Preparation Products

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575474-82-7, R 112 (pharMaceutical)Related Search:

R 112 (pharMaceutical)

Phenol, 3,3'-[(5-fluoro-2,4-pyrimidinediyl)diimino]bis-

(E)-Elafibranor

3,3'-[(5-Fluoro-2,4-pyrimidinediyl)diimino]diphenol

R-112; R 112

R112, >98%

Spleen tyrosine kinase,allergic rhinitis,R112,fast,tryptase,Inhibitor,R 112,phosphorylation,IL-8,GM-CSF,histamine,LTC4,reversible,basophil,R-112,TNF-α,Syk,inhibit

3,3'-((5-Fluoropyrimidine-2,4-diyl)bis(azanediyl))diphenol

575474-82-7