R 112 (pharMaceutical)
- Product Name
- R 112 (pharMaceutical)
- CAS No.
- 575474-82-7
- Chemical Name
- R 112 (pharMaceutical)
- Synonyms
- R112, >98%;R-112; R 112;(E)-Elafibranor;R 112 (pharMaceutical);3,3'-[(5-Fluoro-2,4-pyrimidinediyl)diimino]diphenol;Phenol, 3,3'-[(5-fluoro-2,4-pyrimidinediyl)diimino]bis-;3,3'-((5-Fluoropyrimidine-2,4-diyl)bis(azanediyl))diphenol;Spleen tyrosine kinase,allergic rhinitis,R112,fast,tryptase,Inhibitor,R 112,phosphorylation,IL-8,GM-CSF,histamine,LTC4,reversible,basophil,R-112,TNF-α,Syk,inhibit
- CBNumber
- CB32667633
- Molecular Formula
- C16H13FN4O2
- Formula Weight
- 312.3
- MOL File
- 575474-82-7.mol
R 112 (pharMaceutical) Property
- Boiling point:
- 552.0±60.0 °C(Predicted)
- Density
- 1.494±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:30.0(Max Conc. mg/mL);96.1(Max Conc. mM)
- form
- A crystalline solid
- pka
- 9.48±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 22929
- Product name
- R112
- Packaging
- 1mg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- 22929
- Product name
- R112
- Packaging
- 5mg
- Price
- $356
- Updated
- 2024/03/01
- Product number
- 22929
- Product name
- R112
- Packaging
- 10mg
- Price
- $593
- Updated
- 2024/03/01
- Product number
- 22929
- Product name
- R112
- Packaging
- 25mg
- Price
- $1184
- Updated
- 2024/03/01
- Product number
- R060010
- Product name
- R112
- Packaging
- 5mg
- Price
- $360
- Updated
- 2021/12/16
R 112 (pharMaceutical) Chemical Properties,Usage,Production
Description
R112 is an inhibitor of spleen tyrosine kinase (Syk; IC50 = 226 nM in cultured human mast cells) that acts in an ATP-competitive and reversible manner (Ki = 96 nM). It inhibits mast cell and basophil degranulation induced by anti-IgE cross-linking (EC50s = 353 and 280 nM, respectively). It also inhibits basophil degranulation induced by an allergen with an EC50 value of 490 nM. R112 inhibits the production of leukotriene C4 (LTC4; ) and decreases cytokine levels in cultured human mast cells.
Uses
R 112 is Syk inhibitor. It can be used in biological study and therapeutic use of application of cultured human mast cells (CHMC) for design and structure-activity relationship of IgE-mediated mast cell activation inhibitors.