ChemicalBook > CAS DataBase List > Mc-Val-Cit-PABC-PNP
Mc-Val-Cit-PABC-PNP
- Product Name
- Mc-Val-Cit-PABC-PNP
- CAS No.
- 159857-81-5
- Chemical Name
- Mc-Val-Cit-PABC-PNP
- Synonyms
- Mc-Val-Cit-PABC-PNP;MC-Val-Cit-PAB-PNP;MC-VC-PAB-PNP;MC-Val-Cit-PABC;L-Ornithinamide;MC-VAL-CIT-PAB-PNB;SKL361;CS-1787;AK-32171;VCMMAE linker
- CBNumber
- CB32667895
- Molecular Formula
- C35H43N7O11
- Formula Weight
- 737.76
- MOL File
- 159857-81-5.mol
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Mc-Val-Cit-PABC-PNP Property
- Boiling point:
- 1034.5±65.0 °C(Predicted)
- Density
- 1.338±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMF: 25 mg/ml; DMSO: 20 mg/ml; DMSO:PBS(pH 7.2) (1:4): 0.20 mg/ml
- form
- A crystalline solid
- pka
- 13.24±0.70(Predicted)
- color
- Off-white to light yellow
- InChIKey
- UQRQGHMQKAXOTE-DHIFEGFHSA-N
- SMILES
- C(N)(=O)[C@H](CCCNC(N)=O)N(C(=O)[C@H](C(C)C)NC(=O)CCCCCN1C(=O)C=CC1=O)C1=CC=C(COC(OC2=CC=C([N+]([O-])=O)C=C2)=O)C=C1
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 23881
- Product name
- Mc-Val-Cit-PABC-PNP
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 23881
- Product name
- Mc-Val-Cit-PABC-PNP
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $139
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 23881
- Product name
- Mc-Val-Cit-PABC-PNP
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $243
- Updated
- 2024/03/01
Iris Biotech GmbH
- Product number
- ADC1110
- Product name
- MC-Val-Cit-PAB-PNP
- Packaging
- 250mg
- Price
- $472.5
- Updated
- 2021/12/16
AK Scientific
- Product number
- 3805AH
- Product name
- Mc-Val-Cit-PABC-PNP
- Packaging
- 100mg
- Price
- $594
- Updated
- 2021/12/16
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Mc-Val-Cit-PABC-PNP Chemical Properties,Usage,Production
Description
Mc-Val-Cit-PABC-PNP is a peptide linker molecule used in the synthesis of antibody-drug conjugates (ADCs). It contains a maleimidocaproyl (Mc) group that can be conjugated to an antibody and a p-nitrophenol (PNP) group that allows the peptide to be linked to anticancer compounds, such as doxorubicin or monomethyl auristatin E (MMAE; ). ADCs target specific cell populations to induce a selective response, such as cell death in cancer cells.
Uses
Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC linker used in the synthesis of antibody-drug conjugates.
General Description
Mc-Val-Cit-PABC-PNP is chemically known as L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]-, an enzymatically cleavable linker for antibody-drug conjugates (ADCs). Other ADCs linkers include MC-Val-Cit-PAB-PNP, Mc-Val-Ala-PAB-PNP, Mc-Val-Cit-PABOH, and VcMMAE.
Mc-Val-Cit-PABC-PNP Preparation Products And Raw materials
Raw materials
Preparation Products
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Mc-Val-Cit-PABC-PNP Suppliers
- Tel
- 03-36680489
- Fax
- 03-3668-0520
- Sales-JP@TCIchemicals.com
- Country
- Japan
- ProdList
- 28387
- Advantage
- 80
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View Lastest Price from Mc-Val-Cit-PABC-PNP manufacturers
Xian confluore Biological Technology Co., Ltd.
- Product
- MC-Val-Cit-PAB-PNP 159857-81-5
- Price
- US $0.00/g
- Min. Order
- 5g
- Purity
- >97.00%
- Supply Ability
- 5g
- Release date
- 2024-03-29
Henan Fengda Chemical Co., Ltd
- Product
- L-OrnithinaMide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N5-(aMinocarbonyl)-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]Methyl]phenyl]- 159857-81-5
- Price
- US $50.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-22
Henan Aochuang Chemical Co.,Ltd.
- Product
- Mc-Val-Cit-PABC-PNP 159857-81-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-28