ChemicalBook > CAS DataBase List > Kobe-0065
Kobe-0065
- Product Name
- Kobe-0065
- CAS No.
- 436133-68-5
- Chemical Name
- Kobe-0065
- Synonyms
- CS-1281;Kobe0065;Kobe 0065;Kobe-0065;Kobe 0065, >=98%;Kobe0065/Kobe-0065;Kobe0065, 436133-68-5;N-(3-Chloro-4-Methylphenyl)-2-[2,6-dinitro-4-(trifluoroMethyl)phenyl]-hydrazinecarbothioaMide;Hydrazinecarbothioamide, N-(3-chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]-;Kobe-0065 N-(3-Chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]hydrazinecarbothioamide
- CBNumber
- CB32668155
- Molecular Formula
- C15H11ClF3N5O4S
- Formula Weight
- 449.79
- MOL File
- 436133-68-5.mol
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Kobe-0065 Property
- Melting point:
- >166°C (dec.)
- Boiling point:
- 485.1±55.0 °C(Predicted)
- Density
- 1.653±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- solubility
- DMSO: soluble15mg/mL, clear
- pka
- 9.25±0.70(Predicted)
- form
- powder
- color
- white to beige
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- SML0961
- Product name
- Kobe0065
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $94.3
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- SML0961
- Product name
- Kobe0065
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $424
- Updated
- 2022/05/15
Cayman Chemical
- Product number
- 16261
- Product name
- Kobe 0065
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 16261
- Product name
- Kobe 0065
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $90
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 16261
- Product name
- Kobe 0065
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $161
- Updated
- 2024/03/01
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Kobe-0065 Chemical Properties,Usage,Production
Uses
N-(3-Chloro-4-methylphenyl)-2-[2,6-dinitro-4-(trifluoromethyl)phenyl]-hydrazinecarbothioamide is used in the preparation of pyrazolidine or pyrazole compounds which exhibit mild antimicrobial effects against various strains of bacteria.
Biological Activity
kobe0065 is a small-molecule inhibitor of ras with ki value of 46 μm for the binding of h-ras.gtp to c-raf-1 [1].kobe0065 is a compound screened out by an in silico screen method as a potent inhibitor of the ras–raf interaction. it showed favorite efficacy to inhibit the binding of m-ras.gtp and h-ras.gtp to the ras-binding domain of c-raf-1. kobe0065 also dose-dependently inhibited the binding of h-rasg12v to c-raf-1 in nih 3t3 cells with a rough ic50 value of 10 μm. besides that, 20 μm of kobe0065 effectively suppressed the phosphorylation of down-stream kinases of raf, including mek and erk. in nih 3t3 cells transfected with h-rasg12v, kobe0065 inhibited the colony formation with ic50 value of 0.5 μm. kobe0065 also showed effect on other cancer cells carrying activated ras oncogenes, such as panc-1(k-rasg12v), ht1080 (n-rasq61l) and hct116 (h-rasg13d). moreover, in mice bearing sw480 xenografts, administration of kobe0065 resulted in 40-50% inhibition of the tumor growth at dose of 80 mg/kg. this effect turned to be more distinct when the dose was up to 160 mg/kg [1].
References
[1] shima f, yoshikawa y, ye m, et al. in silico discovery of small-molecule ras inhibitors that display antitumor activity by blocking the ras–effector interaction. proceedings of the national academy of sciences, 2013, 110(20): 8182-8187.
Kobe-0065 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Kobe-0065 manufacturers
Career Henan Chemical Co
- Product
- Kobe-0065 436133-68-5
- Price
- US $1.00/g
- Min. Order
- 100g
- Purity
- 99%
- Supply Ability
- G/KG/T
- Release date
- 2019-12-20
436133-68-5, Kobe-0065Related Search:
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