ChemicalBook > CAS DataBase List > Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate

Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate

Product Name
Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate
CAS No.
625115-52-8
Chemical Name
Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate
Synonyms
Nelociguat;BAY 60-4552;Riociguat-4;Desmethyl Riociguat;N-Desmethyl Riociguat;methyl (4,6-diamino-2;Riociguat Impurity NK1;Riociguat EP Impurity A;Riociguat EP Impurity 4;Riociguat N-Desmethyl Impurity
CBNumber
CB32668342
Molecular Formula
C19H17FN8O2
Formula Weight
408.39
MOL File
625115-52-8.mol
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Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate Property

Melting point:
>196oC (dec.)
Boiling point:
533.3±50.0 °C(Predicted)
Density 
1.58±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly, Heated), Methanol (Very Slightly, Heated)
pka
10.68±0.70(Predicted)
form 
Solid
color 
Light Brown
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
D293285
Product name
N-DesmethylRiociguat
Packaging
50mg
Price
$215
Updated
2021/12/16
TRC
Product number
D293285
Product name
N-DesmethylRiociguat
Packaging
250mg
Price
$545
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611824
Product name
Nelociguat
Packaging
100mg
Price
$555.9
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
69249
Product name
N-Desmethylriociguat
Packaging
10mg
Price
$590
Updated
2021/12/16
ChemScene
Product number
CS-M2183
Product name
Nelociguat
Purity
99.73%
Packaging
200mg
Price
$708
Updated
2021/12/16
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Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate Chemical Properties,Usage,Production

Uses

N-Desmethyl-riociguat, is a complex that is part affiliated with potent oral stimulator for the treatment of pulmonary hypertension.

Definition

ChEBI: Nelociguat is a member of the class of pyrazolopyridines that is 1H-pyrazolo[3,4-b]pyridine which is substituted by a 2-fluorobenzyl and 4,6-diamino-5-[(methoxycarbonyl)amino]pyrimidin-2-yl groups at positions 1 and 3, respectively. It is an active metabolite of riociguat and a soluble guanylate cyclase stimulator developed by Bayer for the treatment of erectile dysfunction and heart failure. It has a role as a soluble guanylate cyclase activator, an antihypertensive agent, a drug metabolite and a vasodilator agent. It is a pyrazolopyridine, a member of monofluorobenzenes, a carbamate ester and an aminopyrimidine.

Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate Suppliers

China 94 France 1 India 3 United States 9 Global 107
Suzhou Zehou Biotechnology Co. , Ltd.
Tel
0512-68716880 18075373931
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18075373931
Email
sales@growingchem.com
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China
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191
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64
Adamas Reagent, Ltd.
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400-6009262 16621234537
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021-64823266
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chenyj@titansci.com
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China
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14103
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Beijing Comparison Pharmaceutical Technology Co., Ltd
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010-010-52878169 15801002657
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sales@bjcomparison.com
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China
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4991
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Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
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info@chemexpress.com
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China
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7552
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Alputon Inc.
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021-60753308-14013
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021-60753309
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China
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MedChemexpress LLC
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021-58955995
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609-228-5909
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sales@medchemexpress.cn
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United States
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4861
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58
Wuxi Zhongkun Biochemical Technology Co., Ltd.
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0510-85629785 18013409632
Fax
051085625359
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sales@reading-chemicals.com
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China
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Hefei Yucheng Pharmaceutical Technology Co., Ltd.
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15385513552
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2904539281@qq.com
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China
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289
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Shandong Boluoda Biological Technology Co., Ltd.
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0531-58190570 15863796298
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2310993908@qq.com
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China
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1296
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58
Shanghai Kewel Chemical Co., Ltd.
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021-64609169 18901607656
Fax
021-64609160
Email
greensnown@163.com
Country
China
ProdList
9906
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50
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View Lastest Price from Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate manufacturers

Career Henan Chemical Co
Product
Name: Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate 625115-52-8
Price
US $5.50/KG
Min. Order
1KG
Purity
98%min
Supply Ability
1kg,10kg,100kg
Release date
2020-01-09

625115-52-8, Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMateRelated Search:

Riociguat Impurtiy 6 Riociguat Impurity 18 Riociguat Impurity 16 2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)-N5,N5- dimethylpyrimidine-4,5,6-triamine 1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxaMide Methyl 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbiMidate 6-amino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl) -7-methyl-7,9-dihydro-8H-purin-8-one isopropyl(4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b] pyridin-3-yl)pyrimidin-5-yl)(methyl)carbamate 6-amino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)- 7,9-dimethyl-7,9-dihydro-8H-purin-8-one BENZENEAZOMALONONITRILE methyl (4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b] pyridin-3-yl)pyrimidin-5-yl)(ethyl)carbamate 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid 1-(3-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboximidamide 6-amino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)- 7,9-dihydro-8H-purin-8-one Riociguat 4,6-PyriMidinediaMine, 2-[1-[(2-fluorophenyl)Methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-(phenylazo)- 2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidine-4,5,6-triaMine

  • Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate
  • Carbamic acid, N-[4,6-diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-, methyl ester
  • N-Desmethyl Riociguat
  • BAY 60-4552
  • Nelociguat
  • methyl N-[4,6-diamino-2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl]carbamate
  • Riociguat N-Desmethyl Impurity
  • methyl (4,6-diamino-2
  • N-Desmethyl Riociguat/Methyl(4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)carbamate
  • Riociguat Impurity NK1
  • Name: Methyl [4,6-diaMino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidin-5-yl]carbaMate
  • Riociguat-4
  • Riociguat Impurity 19/N-Desmethyl Riociguat/Methyl(4,6-diamino-2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-5-yl)carbamate
  • Desmethyl Riociguat
  • Desmethyl RiociguatQ: What is Desmethyl Riociguat Q: What is the CAS Number of Desmethyl Riociguat Q: What is the storage condition of Desmethyl Riociguat Q: What are the applications of Desmethyl Riociguat
  • Carbamic acid,[4,6-diamino-2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl]-, methyl ester
  • inhibit,Inhibitor,Guanylate Cyclase,Nelociguat
  • methyl [(4,6-diamino-2-{1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl}pyrimidin-5-yl)amino]methanoate
  • Riociguat EP Impurity A
  • Riociguat EP Impurity 4
  • Riociguat EP Impurity A (N-Desmethyl Riociguat)
  • 625115-52-8
  • C19H17FN8O2