2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidine-4,5,6-triaMine

Product Name: 2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidine-4,5,6-triaMine
CAS No.: 428854-24-4
Chemical Name: 2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidine-4,5,6-triaMine
Synonyms: Riociguat Impurity 30;riociguat Intermediates;Riociguat Triamino Impurity;N-Desmethyl-N-desmethylcarbamoly Riociguat;2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimid...;2{1[(2fluorophenyl)Methyl]1Hpyrazolo[3,4 b]pyridin3yl}pyriMidine4,5,6triaMine;2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidine-4,5,6-triaMine;2-{1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl}pyrimidine-4,5,6-triamine;4,5,6-Pyrimidinetriamine, 2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-;Riociguat Impurity 21/2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6-triamine
CBNumber: CB52667329
Molecular Formula: C17H15FN8
Formula Weight: 350.35
MOL File: 428854-24-4.mol

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2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidine-4,5,6-triaMine Property

Melting point:: >212°C (dec.)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility: DMSO (Slightly)
form: Solid
color: Dark Yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: F595655
Product name: 2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5,6-triamine
Packaging: 10g
Price: $545
Updated: 2021/12/16

AK Scientific

Product number: 3080AH
Product name: 2-(1-[(2-Fluorophenyl)methyl]-1H-pyrazolo[3,4-B]pyridin-3-yl)pyrimidine-4,5,6-triamine
Packaging: 1g
Price: $131
Updated: 2021/12/16

Matrix Scientific

Product number: 123746
Product name: 2-{1-[(2-Fluorophenyl)methyl]-1H-pyrazolo-[3,4-b]pyridin-3-yl}pyrimidine-4,5,6-triamine
Purity: 97.0%
Packaging: 1g
Price: $594
Updated: 2021/12/16

AK Scientific

Product number: 3080AH
Product name: 2-(1-[(2-Fluorophenyl)methyl]-1H-pyrazolo[3,4-B]pyridin-3-yl)pyrimidine-4,5,6-triamine
Packaging: 25g
Price: $779
Updated: 2021/12/16

AK Scientific

Product number: 3080AH
Product name: 2-(1-[(2-Fluorophenyl)methyl]-1H-pyrazolo[3,4-B]pyridin-3-yl)pyrimidine-4,5,6-triamine
Packaging: 5g
Price: $293
Updated: 2021/12/16

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2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidine-4,5,6-triaMine Chemical Properties,Usage,Production

Uses

2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5,6-triamine is a metabolite of stimulators of soluble guanylate cyclase for the treatment of pulmonary hypertension.

Synthesis

370879-49-5

428854-24-4

General procedure for the synthesis of 2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6-triamine from the compound (CAS: 370879-49-5): to a 100 mL four-necked flask were added DMF (30 mL), LA-1 (5.0 g, 0.012 mol, 1.0 eq.), activated carbon ( 0.5 g) and FeCl3-6H2O (0.8 g, 0.003 mol, 0.25 equiv). After stirring and mixing, the temperature of the reaction system was raised to 60 °C and 80% hydrazine hydrate (15.0 g, 0.238 mol, 10.0 eq.) was slowly added dropwise. After dropwise addition, the reaction was continued at 60 °C for 20 to 24 hours. Upon completion of the reaction, filtration was performed to remove the activated carbon and the filter cake was washed with 25 mL of DMF. The combined filtrates were rotary evaporated at 85 °C to remove the solvent. To the evaporated concentrate was added 25 mL of methanol followed by the slow dropwise addition of 25 mL of water in an ice bath. After completion of the dropwise addition, stirring was continued under an ice bath for 1 hour, followed by diafiltration. The filter cake was dried at 50 °C for 16 h to give LA-2 as a khaki colored solid in a yield of 3.4 g (yield: 86.4%, liquid phase purity 98.1%, melting point 244.4-245.8 °C).

References

[1] Patent: CN107118211, 2017, A. Location in patent: Paragraph 0076; 0077; 0078; 0079; 0080
[2] Patent: CN105461715, 2016, A. Location in patent: Paragraph 0020
[3] Bioorganic and medicinal chemistry, 2002, vol. 10, # 6, p. 1711 - 1717
[4] Patent: WO2017/25981, 2017, A1. Location in patent: Page/Page column 34; 35
[5] Journal of Medicinal Chemistry, 2017, vol. 60, # 12, p. 5146 - 5161

2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidine-4,5,6-triaMine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidine-4,5,6-triaMine Suppliers

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View Lastest Price from 2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidine-4,5,6-triaMine manufacturers

Zison Pharmaceutical (Shandong) Co., Ltd.

Product: 2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidine-4,5,6-triaMine 428854-24-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 100kgs
Release date: 2024-12-18

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Riociguat Impurity 29 428854-24-4
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 0.98
Supply Ability: 10g
Release date: 2024-04-23

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Riociguat Impurity 30
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 0.98
Supply Ability: 10g
Release date: 2024-04-28

428854-24-4, 2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidine-4,5,6-triaMineRelated Search:

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Riociguat Impurity 30

428854-24-4

C17H15FN8