2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidine-4,5,6-triaMine
- Product Name
- 2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidine-4,5,6-triaMine
- CAS No.
- 428854-24-4
- Chemical Name
- 2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidine-4,5,6-triaMine
- Synonyms
- Riociguat Impurity 30;riociguat Intermediates;Riociguat Triamino Impurity;N-Desmethyl-N-desmethylcarbamoly Riociguat;2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimid...;2{1[(2fluorophenyl)Methyl]1Hpyrazolo[3,4 b]pyridin3yl}pyriMidine4,5,6triaMine;2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidine-4,5,6-triaMine;2-{1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl}pyrimidine-4,5,6-triamine;4,5,6-Pyrimidinetriamine, 2-[1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl]-;Riociguat Impurity 21/2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6-triamine
- CBNumber
- CB52667329
- Molecular Formula
- C17H15FN8
- Formula Weight
- 350.35
- MOL File
- 428854-24-4.mol
2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidine-4,5,6-triaMine Property
- Melting point:
- >212°C (dec.)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO (Slightly)
- form
- Solid
- color
- Dark Yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- F595655
- Product name
- 2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5,6-triamine
- Packaging
- 10g
- Price
- $545
- Updated
- 2021/12/16
- Product number
- 3080AH
- Product name
- 2-(1-[(2-Fluorophenyl)methyl]-1H-pyrazolo[3,4-B]pyridin-3-yl)pyrimidine-4,5,6-triamine
- Packaging
- 1g
- Price
- $131
- Updated
- 2021/12/16
- Product number
- 3080AH
- Product name
- 2-(1-[(2-Fluorophenyl)methyl]-1H-pyrazolo[3,4-B]pyridin-3-yl)pyrimidine-4,5,6-triamine
- Packaging
- 5g
- Price
- $293
- Updated
- 2021/12/16
- Product number
- 123746
- Product name
- 2-{1-[(2-Fluorophenyl)methyl]-1H-pyrazolo-[3,4-b]pyridin-3-yl}pyrimidine-4,5,6-triamine
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $594
- Updated
- 2021/12/16
- Product number
- 3080AH
- Product name
- 2-(1-[(2-Fluorophenyl)methyl]-1H-pyrazolo[3,4-B]pyridin-3-yl)pyrimidine-4,5,6-triamine
- Packaging
- 25g
- Price
- $779
- Updated
- 2021/12/16
2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidine-4,5,6-triaMine Chemical Properties,Usage,Production
Uses
2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidine-4,5,6-triamine is a metabolite of stimulators of soluble guanylate cyclase for the treatment of pulmonary hypertension.
Synthesis
370879-49-5
428854-24-4
General procedure for the synthesis of 2-(1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl)pyrimidine-4,5,6-triamine from the compound (CAS: 370879-49-5): to a 100 mL four-necked flask were added DMF (30 mL), LA-1 (5.0 g, 0.012 mol, 1.0 eq.), activated carbon ( 0.5 g) and FeCl3-6H2O (0.8 g, 0.003 mol, 0.25 equiv). After stirring and mixing, the temperature of the reaction system was raised to 60 °C and 80% hydrazine hydrate (15.0 g, 0.238 mol, 10.0 eq.) was slowly added dropwise. After dropwise addition, the reaction was continued at 60 °C for 20 to 24 hours. Upon completion of the reaction, filtration was performed to remove the activated carbon and the filter cake was washed with 25 mL of DMF. The combined filtrates were rotary evaporated at 85 °C to remove the solvent. To the evaporated concentrate was added 25 mL of methanol followed by the slow dropwise addition of 25 mL of water in an ice bath. After completion of the dropwise addition, stirring was continued under an ice bath for 1 hour, followed by diafiltration. The filter cake was dried at 50 °C for 16 h to give LA-2 as a khaki colored solid in a yield of 3.4 g (yield: 86.4%, liquid phase purity 98.1%, melting point 244.4-245.8 °C).
References
[1] Patent: CN107118211, 2017, A. Location in patent: Paragraph 0076; 0077; 0078; 0079; 0080
[2] Patent: CN105461715, 2016, A. Location in patent: Paragraph 0020
[3] Bioorganic and medicinal chemistry, 2002, vol. 10, # 6, p. 1711 - 1717
[4] Patent: WO2017/25981, 2017, A1. Location in patent: Page/Page column 34; 35
[5] Journal of Medicinal Chemistry, 2017, vol. 60, # 12, p. 5146 - 5161
2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidine-4,5,6-triaMine Preparation Products And Raw materials
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View Lastest Price from 2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidine-4,5,6-triaMine manufacturers
- Product
- 2-[1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyriMidine-4,5,6-triaMine 428854-24-4
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 100kgs
- Release date
- 2024-12-18
- Product
- Riociguat Impurity 29 428854-24-4
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 0.98
- Supply Ability
- 10g
- Release date
- 2024-04-23
- Product
- Riociguat Impurity 30
- Price
- US $0.00-0.00/mg
- Min. Order
- 10mg
- Purity
- 0.98
- Supply Ability
- 10g
- Release date
- 2024-04-28