HIF-1alpha/2alpha Inhibitor
- Product Name
- HIF-1alpha/2alpha Inhibitor
- CAS No.
- 329932-55-0
- Chemical Name
- HIF-1alpha/2alpha Inhibitor
- Synonyms
- FM19G11;FM 19G11 NEW;FM19G11 >=98% (HPLC);HIF-1alpha/2alpha Inhibitor;HIF-1α/2α Inhibitor IV, FM19G11;2-Oxo-2-(p-tolyl)ethyl 3-(2,4-dinitrobenzamido)benzoate;[2-oxo-2-(p-tolyl)ethyl] 3-[(2,4-dinitrobenzoyl)amino]benzoate;3-[(2,4-Dinitrobenzoyl)amino]-benzoic acid 2-(4-methylphenyl)-2-oxoethyl ester;Benzoic acid, 3-[(2,4-dinitrobenzoyl)amino]-, 2-(4-methylphenyl)-2-oxoethyl ester
- CBNumber
- CB32668403
- Molecular Formula
- C23H17N3O8
- Formula Weight
- 463.4
- MOL File
- 329932-55-0.mol
HIF-1alpha/2alpha Inhibitor Property
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥40mg/mL
- form
- powder
- color
- off-white to light brown
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- F8807
- Product name
- FM19G11
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $67.2
- Updated
- 2024/03/01
- Product number
- F8807
- Product name
- FM19G11
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $543
- Updated
- 2024/03/01
- Product number
- 6653
- Product name
- FM19G11
- Purity
- ≥98%(HPLC)
- Packaging
- 25
- Price
- $463
- Updated
- 2021/12/16
- Product number
- 6653
- Product name
- FM19G11
- Purity
- ≥98%(HPLC)
- Packaging
- 5
- Price
- $119
- Updated
- 2021/12/16
- Product number
- BF168364
- Product name
- FM 19G11 NEW
- Packaging
- 10mg
- Price
- $125
- Updated
- 2021/12/16
HIF-1alpha/2alpha Inhibitor Chemical Properties,Usage,Production
Uses
FM19G11 has been used as ahypoxia-inducible factor-1α (HIF- 1α):
- to study the effects ofFM19G11-loaded gold nanoparticles (NPs) on self-renewal and proliferation of ependymal stem progenitor cells (epSPCs) of mice
- to study its effects on the O6-methylguanine DNA-methyltransferase (MGMT) expression in glioblastoma (GBM) cells
- to study its effects on microphthalmia-associated transcription factor (MITF) expression in melanoma cell line
Definition
ChEBI: 3-[[(2,4-dinitrophenyl)-oxomethyl]amino]benzoic acid [2-(4-methylphenyl)-2-oxoethyl] ester is a member of benzamides.
Biochem/physiol Actions
FM19G11 is an inhibitor of Hypoxia Inducible Factors α (HIFα), reported to affect self-renewal and differentiation of stem cells. Hypoxia-inducible factors (HIFs) are transcription factors that respond to changes in available oxygen in the cellular environment. Among other functions (like angiogenesis), HIFα proteins affect the self-renewal and the differentiation processes of stem cells. FM19G11 inhibits the HIFα proteins that repress the target genes of the two α subunits, in various tumor cell lines as well as in adult and embryonic stem cell (ESC) models.
storage
Store at +4°C
HIF-1alpha/2alpha Inhibitor Preparation Products And Raw materials
Raw materials
Preparation Products
HIF-1alpha/2alpha Inhibitor Suppliers
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- Country
- United Kingdom
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