GNF179 Metabolite
- Product Name
- GNF179 Metabolite
- CAS No.
- 1310455-86-7
- Chemical Name
- GNF179 Metabolite
- Synonyms
- EOS-60885;GNF179 Metabolite;2-(4-fluorophenyl)-8,8-dimethyl-6,7-dihydro-5H-imidazo[1,2-a]pyrazine;2-(4-fluorophenyl)-8,8-dimethyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine;Imidazo[1,2-a]pyrazine, 2-(4-fluorophenyl)-5,6,7,8-tetrahydro-8,8-dimethyl-
- CBNumber
- CB32674428
- Molecular Formula
- C14H16FN3
- Formula Weight
- 245.3
- MOL File
- 1310455-86-7.mol
GNF179 Metabolite Property
- Boiling point:
- 428.6±40.0 °C(Predicted)
- Density
- 1.23±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Powder
- pka
- 8.43±0.40(Predicted)
N-Bromosuccinimide Price
- Product number
- CD31003928
- Product name
- GNF179Metabolite
- Purity
- 98+%
- Packaging
- 5mg
- Price
- $228
- Updated
- 2021/12/16
- Product number
- CD31003928
- Product name
- GNF179Metabolite
- Purity
- 98+%
- Packaging
- 10mg
- Price
- $326
- Updated
- 2021/12/16
- Product number
- CD31003928
- Product name
- GNF179Metabolite
- Purity
- 98+%
- Packaging
- 50mg
- Price
- $977
- Updated
- 2021/12/16
- Product number
- CD31003928
- Product name
- GNF179Metabolite
- Purity
- 98+%
- Packaging
- 100mg
- Price
- $1367
- Updated
- 2021/12/16
- Product number
- E3170
- Product name
- 2-(4-fluorophenyl)-5,6,7,8-tetrahydro-8,8-dimethyl-Imidazo[1,2-a]pyrazine
- Purity
- 97.00%
- Packaging
- 1G
- Price
- $1760
- Updated
- 2021/12/16
GNF179 Metabolite Chemical Properties,Usage,Production
Uses
GNF179 metabolite is the metabolite of GNF179, which is an optimized 8,8-dimethyl IP analog that exhibited the potency(4.8 nM against the multidrug resistant strain W2) in vitro metabolic stability and in vivo oral bioavailability. IC50 value: Target: Anti-parasitic agent GNF179 exhibits a low clearance (CL=22 ml/min/kg, ~25% of hepatic blood flow in mice), a large volume of distribution (steady-state volume of distribution, Vss=11.8 l/kg), a moderate residence time (MRT=9 hours) and suitable terminal half-life (t1/2=8.9 hours). GNF179 reduced Plasmodium berghei parasitemia levels by 99.7% with a single 100 mg/kg oral dose, and prolonged mouse survival by an average of 19 days. GNF179 was able to protect against an infectious P. berghei sporozoite challenge with a single oral dose at 15 mg/kg while NITD609 was not.
References
[1] Meister S, et al. Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science. 2011 Dec 9;334(6061):1372-7. DOI:10.1126/science.1211936
GNF179 Metabolite Preparation Products And Raw materials
Raw materials
Preparation Products
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