HG-9-91-01

Product Name: HG-9-91-01
CAS No.: 1456858-58-4
Chemical Name: HG-9-91-01
Synonyms: HG-9-91-01;SIK INHIBITOR 1;Salt-inducible Kinase (SIK),HG99101,SIK inhibitor-1,SIK inhibitor1,inhibit,HG 9 91 01,Inhibitor;1-(2,4-dimethoxyphenyl)-3-(2,6-dimethylphenyl)-1-[6-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]urea;1-(2,4-dimethoxyphenyl)-3-(2,6-dimethylphenyl)-1-(6-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)urea;N-(2,4-Dimethoxyphenyl)-N'-(2,6-dimethylphenyl)-N-[6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]urea;Urea, N-(2,4-dimethoxyphenyl)-N'-(2,6-dimethylphenyl)-N-[6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-
CBNumber: CB32676109
Molecular Formula: C32H37N7O3
Formula Weight: 567.68
MOL File: 1456858-58-4.mol

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HG-9-91-01 Property

Boiling point:: 790.8±60.0 °C(Predicted)
Density: 1.257±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: ≥56.8 mg/mL in DMSO; ≥27.3 mg/mL in EtOH; ≥6.35 mg/mL in H2O with ultrasonic
form: Powder
pka: 13.11±0.70(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19179
Product name: HG-9-91-01
Purity: ≥95%
Packaging: 500μg
Price: $65
Updated: 2024/03/01

Cayman Chemical

Product number: 19179
Product name: HG-9-91-01
Purity: ≥95%
Packaging: 1mg
Price: $121
Updated: 2024/03/01

Cayman Chemical

Product number: 19179
Product name: HG-9-91-01
Purity: ≥95%
Packaging: 5mg
Price: $505
Updated: 2024/03/01

Cayman Chemical

Product number: 19179
Product name: HG-9-91-01
Purity: ≥95%
Packaging: 10mg
Price: $884
Updated: 2024/03/01

ApexBio Technology

Product number: B1052
Product name: HG-9-91-01
Packaging: 50mg
Price: $795
Updated: 2021/12/16

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HG-9-91-01 Chemical Properties,Usage,Production

Definition

ChEBI: HG-9-91-01 is a member of the class of phenylureas that is a potent inhibitor of salt-inducible kinase 2, a potential target protein for therapy in ovarian cancer. It has a role as an antineoplastic agent and a salt-inducible kinase 2 inhibitor. It is a dimethoxybenzene, an aminopyrimidine, a N-arylpiperazine, a N-alkylpiperazine, a secondary amino compound and a member of phenylureas.

Biological Activity

hg-9-91-01 is a pan-sik (salt-inducible kinases) inhibitor with ic50 values of 0.92nm, 6.6nm and 9.6nm for sik1, sik2, sik3, respectively [1].siks restrict the formation of regulatory macrophages. the inhibition of these enzymes is thought to have potential for treating inflammatory and autoimmune diseases. hg-9-91-01 potently inhibits siks through targeting both the atp-binding site and the small hydrophobic pocket. it is reported that, besides siks, hg-9-91-01 also inhibits various protein tyrosine kinases such as src, btk, fgf and ephrin receptors. but other ampk-related kinase subfamily members are not sensitive to hg-9-91-01. hg-9-91-01 can promote lps-stimulated il-10 production, creb-dependent gene transcription, inhibit proinflammatory cytokine secretion and induce the expression of regulatory macrophage markers [1].

References

[1] clark k, mackenzie k f, petkevicius k, et al. phosphorylation of crtc3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages. proceedings of the national academy of sciences, 2012, 109(42): 16986-16991.

HG-9-91-01 Preparation Products And Raw materials

Raw materials

Preparation Products

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HG-9-91-01 Suppliers

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HG-9-91-01

N-(2,4-Dimethoxyphenyl)-N'-(2,6-dimethylphenyl)-N-[6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]urea

1-(2,4-dimethoxyphenyl)-3-(2,6-dimethylphenyl)-1-(6-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)urea

SIK INHIBITOR 1

1-(2,4-dimethoxyphenyl)-3-(2,6-dimethylphenyl)-1-[6-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]urea

Urea, N-(2,4-dimethoxyphenyl)-N'-(2,6-dimethylphenyl)-N-[6-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-4-pyrimidinyl]-

Salt-inducible Kinase (SIK),HG99101,SIK inhibitor-1,SIK inhibitor1,inhibit,HG 9 91 01,Inhibitor

1456858-58-4

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