Paprotrain

Product Name: Paprotrain
CAS No.: 57046-73-8
Chemical Name: Paprotrain
Synonyms: Paprotrain;Paprotrain, 10 mM in DMSO;Paprotrain, MKLP-2 inhibitor;Kinesin,Paprotrain,Inhibitor,inhibit;2-(1H-Indol-3-yl)-3-pyridin-3-yl-acrylonitrile;(Z)-2-(1H-Indol-3-yl)-3-(pyridin-3-yl)acrylonitrile;(Z)-α-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile;1H-Indole-3-acetonitrile, α-(3-pyridinylmethylene)-, (αZ)-;(alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile
CBNumber: CB32677878
Molecular Formula: C16H11N3
Formula Weight: 245.28
MOL File: 57046-73-8.mol

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Paprotrain Property

Melting point:: 202℃
storage temp.: 2-8°C
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:6): 0.1 mg/ml; Ethanol: 0.2 mg/ml
form: Powder
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TCI Chemical

Product number: P3091
Product name: Paprotrain
Packaging: 25MG
Price: $291
Updated: 2025/07/31

Cayman Chemical

Product number: 10524
Product name: Paprotrain
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 10524
Product name: Paprotrain
Purity: ≥95%
Packaging: 5mg
Price: $56
Updated: 2024/03/01

Cayman Chemical

Product number: 10524
Product name: Paprotrain
Purity: ≥95%
Packaging: 10mg
Price: $78
Updated: 2024/03/01

Tocris

Product number: 4813
Product name: Paprotrain
Purity: ≥99%(HPLC)
Packaging: 10
Price: $81
Updated: 2021/12/16

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Paprotrain Chemical Properties,Usage,Production

Description

Mitotic kinesin-like protein 2 (MKLP-2) is an N-terminal motor from the kinesin-6 family that is essential for normal cleavage furrow ingression and cytokinesis. Its activity mediates the relocation of the chromosome passenger proteins Aurora B kinase and survivin from the centromeres to the central spindle in anaphase cells in order to facilitate cytokinesis, avoiding the generation of binucleated cells. Paprotrain, PAssenger PROteins TRAnsport INhibitor, is the first known inhibitor of MKLP-2. It is a cell-permeable, reversible inhibitor uncompetitive with ATP (K_i = 3.4 μM) and noncompetitive with microtubules (K_i = 1.6 μM), demonstrating ATPase inhibition of basal and microtubule-stimulated activities with IC₅₀ values of 1.35 and 0.83 μM, respectively. Paprotrain does not inhibit twelve additional kinesins, including the closely related kinesin-6 motors MKLP-1 and MPP1. Incubation with 10-50 μM paprotrain results in binucleated cells, perturbing relocation of Aurora B kinase and survivin without affecting microtubule polymerization.

Uses

Paprotrain is a cell-permeable inhibitor of the kinesin-6 family member KIF20A (MKLP-2).

IC 50

MKLP-2: 1.35 μM (IC₅₀)

References

[1] DR. SERGEY TCHERNIUK. Relocation of Aurora B and Survivin from Centromeres to the Central Spindle Impaired by a Kinesin-Specific MKLP-2 Inhibitor?[J]. Angewandte Chemie International Edition, 2010, 49 44: 8228-8231. DOI: 10.1002/anie.201003254

Paprotrain Preparation Products And Raw materials

Raw materials

Preparation Products

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Paprotrain Suppliers

China 58 United Kingdom 2 United States 10 USA 1 Global 71

Shanghai Tauto Biotech Co., Ltd.

Tel: 021-51320588
Fax: 0086-21-51320502
Email: tauto@tautobiotech.com
Country: China
ProdList: 3988
Advantage: 66

EMMX Biotechnology LLC

Tel: 888-539-0666
Fax: 888-539-0666
Email: info@emmx.com
Country: United States
ProdList: 8447
Advantage: 60

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

Jinan Kaixi Biotechnology Co., Ltd.

Tel: 13370511208; 15853141736
Fax: -
Email: 461667177@qq.com
Country: China
ProdList: 613
Advantage: 55

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 8011
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8000
Advantage: 62

MQ (shanghai) Pharmaceuticals Co., Ltd.

Tel: 13761635123
Fax: 1014988033@qq
Email: 1014988033@qq.com
Country: China
ProdList: 4941
Advantage: 55

Fan De(Beijing) Biotechnology Co., Ltd.

Tel: 15911056312
Email: liming@bio-fount.com
Country: China
ProdList: 9729
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

57046-73-8, PaprotrainRelated Search:

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(Z)-α-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile

1H-Indole-3-acetonitrile, α-(3-pyridinylmethylene)-, (αZ)-

Kinesin,Paprotrain,Inhibitor,inhibit

(Z)-2-(1H-Indol-3-yl)-3-(pyridin-3-yl)acrylonitrile

Paprotrain, MKLP-2 inhibitor

Paprotrain, 10 mM in DMSO

57046-73-8