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Paprotrain

Product Name
Paprotrain
CAS No.
57046-73-8
Chemical Name
Paprotrain
Synonyms
Paprotrain;Kinesin,Paprotrain,Inhibitor,inhibit;2-(1H-Indol-3-yl)-3-pyridin-3-yl-acrylonitrile;(Z)-2-(1H-Indol-3-yl)-3-(pyridin-3-yl)acrylonitrile;(Z)-α-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile;1H-Indole-3-acetonitrile, α-(3-pyridinylmethylene)-, (αZ)-;(alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile
CBNumber
CB32677878
Molecular Formula
C16H11N3
Formula Weight
245.28
MOL File
57046-73-8.mol
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Paprotrain Property

Melting point:
202℃
storage temp. 
2-8°C
solubility 
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:6): 0.1 mg/ml; Ethanol: 0.2 mg/ml
form 
Powder
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10524
Product name
Paprotrain
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
10524
Product name
Paprotrain
Purity
≥95%
Packaging
5mg
Price
$56
Updated
2024/03/01
Cayman Chemical
Product number
10524
Product name
Paprotrain
Purity
≥95%
Packaging
10mg
Price
$78
Updated
2024/03/01
Tocris
Product number
4813
Product name
Paprotrain
Purity
≥99%(HPLC)
Packaging
10
Price
$81
Updated
2021/12/16
Tocris
Product number
4813
Product name
Paprotrain
Purity
≥99%(HPLC)
Packaging
50
Price
$342
Updated
2021/12/16
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Paprotrain Chemical Properties,Usage,Production

Description

Mitotic kinesin-like protein 2 (MKLP-2) is an N-terminal motor from the kinesin-6 family that is essential for normal cleavage furrow ingression and cytokinesis. Its activity mediates the relocation of the chromosome passenger proteins Aurora B kinase and survivin from the centromeres to the central spindle in anaphase cells in order to facilitate cytokinesis, avoiding the generation of binucleated cells. Paprotrain, PAssenger PROteins TRAnsport INhibitor, is the first known inhibitor of MKLP-2. It is a cell-permeable, reversible inhibitor uncompetitive with ATP (Ki = 3.4 μM) and noncompetitive with microtubules (Ki = 1.6 μM), demonstrating ATPase inhibition of basal and microtubule-stimulated activities with IC50 values of 1.35 and 0.83 μM, respectively. Paprotrain does not inhibit twelve additional kinesins, including the closely related kinesin-6 motors MKLP-1 and MPP1. Incubation with 10-50 μM paprotrain results in binucleated cells, perturbing relocation of Aurora B kinase and survivin without affecting microtubule polymerization.

Uses

Paprotrain is a cell-permeable inhibitor of the kinesin-6 family member KIF20A (MKLP-2).

Paprotrain Preparation Products And Raw materials

Raw materials

Preparation Products

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Paprotrain Suppliers

China 41 United Kingdom 2 United States 8 USA 1 Global 52
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Fax
0086-21-51320502
Email
tauto@tautobiotech.com
Country
China
ProdList
3989
Advantage
66
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8449
Advantage
60
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9708
Advantage
58
Jinan Kaixi Biotechnology Co., Ltd.
Tel
15853141736
Fax
-
Email
461667177@qq.com
Country
China
ProdList
510
Advantage
55
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
3552
Advantage
55
ShangHai Biochempartner Co.,Ltd
Tel
17754423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8019
Advantage
62
MQ (shanghai) Pharmaceuticals Co., Ltd.
Tel
13761635123
Fax
1014988033@qq
Email
1014988033@qq.com
Country
China
ProdList
4997
Advantage
55
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9730
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
19892
Advantage
58
Career Henan Chemica Co
Tel
+86-0371-86658258 15093356674;
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
ProdList
30255
Advantage
58

57046-73-8, PaprotrainRelated Search:

METHYLENECYCLOHEXANE Nicotinamide

  • Paprotrain
  • (alphaZ)-alpha-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile
  • 2-(1H-Indol-3-yl)-3-pyridin-3-yl-acrylonitrile
  • (Z)-α-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile
  • 1H-Indole-3-acetonitrile, α-(3-pyridinylmethylene)-, (αZ)-
  • Kinesin,Paprotrain,Inhibitor,inhibit
  • (Z)-2-(1H-Indol-3-yl)-3-(pyridin-3-yl)acrylonitrile
  • 57046-73-8