ChemicalBook > CAS DataBase List > AMG 925

AMG 925

Product Name
AMG 925
CAS No.
1401033-86-0
Chemical Name
AMG 925
Synonyms
FLX925;FLX-925;AMG 925;CS-1594;FLX 925.;AMG 925 (FLX925;FLX925 (AMG-925);AMG 925;AMG925;AMG-925;AMG925; AMG-925; AMG 925; FLX925; FLX-925; FLX 925.;2-Hydroxy-1-(2-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-
CBNumber
CB32685918
Molecular Formula
C26H29N7O2
Formula Weight
471.55
MOL File
1401033-86-0.mol
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AMG 925 Property

Boiling point:
712.3±70.0 °C(Predicted)
Density 
1.48±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
insoluble in DMSO; insoluble in H2O; insoluble in EtOH
form 
solid
pka
13.41±0.10(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29245
Product name
AMG 925
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
29245
Product name
AMG 925
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
29245
Product name
AMG 925
Packaging
10mg
Price
$153
Updated
2024/03/01
Cayman Chemical
Product number
29245
Product name
AMG 925
Packaging
25mg
Price
$267
Updated
2024/03/01
TRC
Product number
A604290
Product name
AMG925
Packaging
50mg
Price
$310
Updated
2021/12/16
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AMG 925 Chemical Properties,Usage,Production

Description

AMG 925 is a dual inhibitor of FMS-related tyrosine kinase 3 (FLT3) and cyclin-dependent kinase 4 (Cdk4; IC50s = 1 and 3 nM, respectively). It is selective for FLT3 and Cdk4 over Cdk1 (IC50 = 2.22 μM). AMG 925 also binds to FLT3ITD, FLT3D835Y, FLT3D835H, FLT3K663Q, and FLT3N841I (Kds = 1-4 nM). It inhibits proliferation of MOLM-13, COLO 205, and U937 cancer cells (IC50s = 19, 55, and 52 nM, respectively). AMG 925 (50, 75, and 150 mg/kg) reduces intratumor levels of pSTAT5 and pRb and inhibits tumor growth in a MOLM-13 acute myeloid leukemia (AML) mouse xenograft model.

Uses

AMG 925 is a FLT3 and CDK4 Dual Kinase Inhibitor with Preferential Affinity for the Activated State of FLT3.

Definition

ChEBI: AMG-925 is an organic heterotricyclic compound that is 9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidine which is substituted by a [6-(hydroxyacetyl)-5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl]nitrilo group at position 2 and by a trans-4-methylcyclohexyl group at position 9. It is a FLT3 and CDK4 dual kinase inhibitor that has antineoplastic activity. Currently under clinical investigation in patients with relapsed or refractory acute myeloid leukemia (AML). It has a role as an antineoplastic agent, an apoptosis inducer, an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor and an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor. It is a secondary amino compound, a tertiary amino compound, a naphthyridine derivative, a primary alpha-hydroxy ketone and an organic heterotricyclic compound.

target

FLT3

References

[1] keegan k, li c, li z, ma j, ragains m, coberly s, hollenback d, eksterowicz j, liang l, weidner m, huard j, wang x, alba g, orf j, lo mc, zhao s, ngo r, chen a, liu l, carlson t, quéva c, mcgee lr, medina j, kamb a, wickramasinghe d, dai k. preclinical evaluation of amg 925, a flt3/cdk4 dual kinase inhibitor for treating acute myeloid leukemia. mol cancer ther. 2014 apr;13(4):880-9.

AMG 925 Preparation Products And Raw materials

Raw materials

Preparation Products

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AMG 925 Suppliers

China 49 United States 15 Global 64
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
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58
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
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60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19553
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38632
Advantage
58
United States Biological
Tel
--
Fax
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Email
sales@advtechind.com
Country
United States
ProdList
6075
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58
ApexBio Technology
Tel
--
Fax
--
Email
sales@apexbt.com
Country
United States
ProdList
6251
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58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
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81
United States Biological
Tel
--
Fax
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Email
chemicals@usbio.net
Country
United States
ProdList
6214
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80
Matrix Scientific
Tel
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Email
sales@matrixscientific.com
Country
United States
ProdList
6632
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ChemieTek
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info@chemietek.com
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United States
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219
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50

1401033-86-0, AMG 925Related Search:


  • AMG 925
  • 1-[7,8-Dihydro-2-[[9-(trans-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl]amino]-1,6-naphthyridin-6(5H)-yl]-2-hydroxyethanone
  • 2-Hydroxy-1-(2-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-
  • Ethanone, 1-[7,8-dihydro-2-[[9-(trans-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl]amino]-1,6-naphthyridin-6(5H)-yl]-2-hydroxy-
  • AMG 925;AMG925;AMG-925
  • CS-1594
  • 2-Hydroxy-1-(2-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)ethanone
  • AMG925; AMG-925; AMG 925; FLX925; FLX-925; FLX 925.
  • FLX 925.
  • FLX925
  • FLX-925
  • AMG 925 (FLX925
  • FLX925 (AMG-925)
  • CDK,AMG 925,Cluster of differentiation antigen 135,FLT3,Cyclin dependent kinase,inhibit,CD135,AMG-925,AMG925,Inhibitor,Fms like tyrosine kinase 3
  • 1401033-86-0
  • C26H29N7O2